Excerpts

Consistent with these findings, the expression of a master regulator of lipogenic genes, Srebp1c (sterol regulatory element-binding protein1c), was reduced dramatically in steatotic livers compared with normal livers, and Hif-1α deficiency showed a trend toward further decreased expression of Srebp1c (Fig. 3 ).

Parametric two-tailed independent t-test analysis were used to compare means between experimental groups and a P-value of < 0.01 was considered statistically highly significant.

A correction for multiple comparisons based on False Discovery Rate (FDR) confirmed the latter evidence, with the only exception of the immediate recall score which showed a marginal trend (p-corrected = 0.058).

However, the correlation coefficients in other places are almost insignificant.

However, a pronounced trend can be seen in the amplitude of the signal, and this is further emphasised in Fig. 7 , where it is seen that the amplitude of the mean 2D-FT for each hour increases steadily from midnight, peaks at 2 pm and decreases again until 11 pm.

A decreasing trend in soil C levels was noticed with the increase in soil depth in all the soil types (SI Tables 2–4).

Plasma and urine acylcarnitines showed a trend towards an increase in the periovulatory phase Of the 50 compounds tested in the acylcarnitine panel, 19 were statistically significant (Table 2 ) in plasma and 16 statistically significant in urine (p < 0.05) (Table 2 ).

Vimentin low classified patients showed a trend towards improved clinical outcome (Fig. 3b ).

3C ) also showed a main effect for [Reward – No Reward] ( p = 0.021), but this was of marginal significance and would not survive Bonferroni correction for three separate analyses.

These data have provided important new insights into understanding of simvastatin-induced anti-apoptotic and pro-survival actions in experimental sepsis and related organ injury stress, that may be significant basis for the clinical use of statins for SIMD, but this warrants further clinical investigation.

Using Fisher’s exact test, these ratios indicated a highly significant overrepresentation of chymotryptic peptides among the ASFV derived peptides.

The difference between the profiles obtained from the soluble and aggregation-prone protein datasets is about 0.2 kcal/mol, and thus highly significant.

We observed an increasing trend in sphingomyelin metabolites after combination therapy.

The adjusted OR showed an increasing trend over hypertension stages, but no significant difference was found between elevated and normal stages.

The association of coronary heart disease (CHD) and CKD became marginally significant with a smaller effect estimate.

We regarded p < 0.05 as significant and p < 0.01 highly significant.

Likewise, an increasing trend in soybean AA concentration was documented from northern to southern regions in China 13 .

The highly significant proteins were categorised into five groups depending on their functions and association with the pathogenesis of steatosis: (i) apoptosis and autophagy, (ii) energy maintenance, (iii) anti-oxidative stress, (iv) liver injury (e.g. fat deposition) and (v) liver function improvement (e.g. nitrogen waste detoxicfication and folate-binding protein).

The averaged quantity denoted as a black line in both graphs suggests a decreasing trend for the additised fuel up to the last part closer to the outlet.

Animals fed a western diet showed a trend to lower locomotive activity compared to controls, but differences were not significant (Fig. 1a ).

However, the P values were <0.001 in 7 datasets, indicating that GR downregulation was highly significant in PCa tissues compared to normal tissues.

At 0.1% of GO-Au, we observed a decreasing trend (even though it was not statistically significant) in degradation of the scaffold, however at 0.25% and 0.5% concentrations of GO-Au, the degradation rate was significantly reduced in a dose dependent manner compared to naïve chitosan scaffold (Fig. 3A ).

Our data revealed that there was an increasing trend in the conductivity of scaffold with the inclusion of GO at a concentration of 0.5%, but this was not statistically significant.

High temperature friction test on SiOC-ZrSi 2 showed a decreasing trend in COF with increasing temperature to 400 °C.

Changes in amino acid properties upon mutation were a notable trend throughout the SNPs.