Excerpts

P values < 6.0 × 10 −5 (0.05/26 SNPs/32 sectors) and <4.8 × 10 −4 (0.05/26 SNPs/4 sectors) were considered statistically significant for cpRNFL in the 32-sector and 4-sectors analyses, respectively, whereas P-values < 0.0016 (0.05/32 sectors) and <0.0125 (0.05/4 sectors) were considered marginally significant, respectively.

Nominally significant associations were found for rare functional variants in BBS1 , BBS9 , GNAS , MKKS , CLOCK and ANGPTL6 .

One SNP from GWAS was significantly associated with keratoconus, i.e., RXRA-COL5A1 rs1536482 (P = 1.5 × 10 −5 , I 2 = 0), while FOXO1 rs2721051 (P = 9.4 × 10 −3 , I 2 = 0), BANP-ZNF469 rs9938149 (P = 0.017, I 2 = 27%), COL4A4 (rs2228557, P = 0.020, I 2 = 70%) and COL4A3 (c.2685 A > C, P = 0.032, I 2 = 0) were nominally significant (Table 3 ).

The heat associations showed an increasing trend.

A decreasing trend is clearly noticed as the number of layers increases.

Figure 4Fi-iii , shows representative examples comparing the implantation sites and the reabsorption signs of uteri from each of the groups. Overall, the PS group showed a trend toward the same pattern of results as the AS group (Figs 1 – 4 ), but the differences with the control group were not significant (p’s > 0.05).

In this population, expression of p41 was slightly higher in parasites infecting children with SM, than UM (although very borderline significance).

Likewise, pathway ontology analyses revealed highly significant over-representation of genes associated with the terms B cell receptor signaling pathway and Intestinal immune network for IgA production (Supplementary Table S3 ).

That is to say, the application of gradient magnetic field can depress the mean Δ T . The recalescence extent, Δ T R-N , shows opposite trend behavior compared to that in homogeneous magnetic field where an increasing trend is evidenced from 177 K to 194 K when a 93 T/m gradient magnetic field is applied.

However, in October 2011, a negative trend was evident for P . strigosa and M . cavernosa , after exposure to heat-stress (Fig. 6o,p ; Tables S8 – S9 ).

Protamines are not only important for condensation of sperm chromatin and protection of the paternal genome but protamines may be significant in reprograming of the imprinting pattern of the gamete, and thus, in epigenetic regulation 41 .

In conclusion, our study found that about one-third of Chinese young men of reproductive age in rural areas were overweight or obese, and we also observed an increasing trend in the prevalence across the study years.

These cytological diagnoses are determined, as follows: 1) Bethesda I, nondiagnostic or unsatisfactory, 2) Bethesda II, benign, 3) Bethesda III, atypical of indeterminate significance or follicular lesion of indeterminate significance, 4) Bethesda IV, follicular neoplasm or suspicious for a follicular neoplasm, 5) Bethesda V, suspicious for malignancy, and 6) Bethesda VI, malignant.

First, there may be significant differences in the neural efficiency level of the participants, hence explaining the lack of significant correlation between performance and HbO2 concentration.

We did not find significant differences in the subset distribution of DN TCRγδ+ T-cells, despite an increasing trend in the effector population (Fig. 6g ).

RecAN showed a higher rate of lose-shift behaviour and a statistical trend for a higher rate of win-shift behaviour.

Nonetheless, this rate is almost insignificant even close to the galactic core, reaching only around 1% of planets being sterilised.

As described below, 162 highly significant GO terms of Biological Process and Molecular Function or the KEGG pathways were identified in eight tissues (FDR < 0.05, fold enrichment > 2).

In addition, there were clear trends that almost reached significance for a lower latency to show rearing behaviour in the outer zone and the frequency of jumping behaviour during the test.

The latency to first rear (defined as those instances in which the mouse stood on its hind legs) within the outer zone showed a trend towards lower values in KO mice that just failed to reach significance (Fig. 5a ).

PERMANOVA analysis detected marginally significant differences between smothering times in C. foliascens (Table 2C ).

The p-value was two-tailed and considered as statistically significant or highly significant if it was less than 0.05 or 0.01, respectively.

Statistical significance was set as follows: a P value of 0.05 was significant, and a value of 0.01 was highly significant.

Subsequent studies indicated an increased level of FoxO1 nuclear translocation that was induced by KPC-exosomes, while Phospho-FoxO1 showed a decreasing trend (Fig. 4A and B ).

The nuclear FoxO1 levels displayed an increasing trend (normalized to the nuclear protein Lamin A/C levels; Fig. 4A ) in contrast to the nuclear Phospho-FoxO1 levels (Fig. 4B ).