Excerpts

One interesting example is glycan 5402, which had a small positive correlation (PPMCC 0.28) with A1AT’s serum concentration when present at site A1AT site 70 ( P = 0.006) but had a strong highly significant negative correlation (PPMCC -0.81) with the serum concentration of A1AT when present at A1AT site 271 ( P < 2E−16) (Fig. 2 F).

In particular, in 10-fold cross-validation experiments on held-out genes, we obtained a mean Spearman rank correlation between predicted and measured gene expression changes of 0.174, a modest but highly significant result ( P <2e−16), shown in Figure 2A .

Indeed, the fit of all points rather than of the medians were poor although the (anti-)correlation was highly significant (R 2 = 0.01, p < 2e −16 in both cases).

We observed a highly significant difference from the expected equal distribution (χ2 = 83.143, df = 3, p < 2 × 10−16).

We found a highly significant relationship between NPAS4 affinity scores and NPAS4 ChIP-seq peak intensity (mouse and rat P < 2 × 10 −16 , Supplementary Fig.

As for senior authorship, the difference between men and women was highly significant in both the 1999 (166 vs. 47, p = 2e-16), and in the 2009 cohort (188 vs. 115, p = 3e-5), but inspection of the absolute difference reveals that this difference is diminishing.

All other pairwise comparisons were highly significant ( p < 2e-16 ).

The differences between transdifferentiation factors and all other TFs are highly significant (one-sided Kolmogorov-Smirnov (KS) test, expression p-value<2*10 −16 ; H3K27me3 p-value<2*10 −16 ).

The ANOVA test revealed that the prediction of fresh weight by the finalized model was highly significant ( p < 2e-16).

The effective degrees of freedom (edf) for the smoothing term were 8.918, and the corresponding F-statistic and p -value indicated that the smoothing term was highly significant ( p -value < 2e-16).

An overall log‐rank test comparing survival curves across the eight groups defined by larval treatment, adult treatment, and sex showed highly significant differences (χ2 = 146, df = 7, p < 2e–16).

Logistic regression analysis showed that the correlation between the proportion of proplatelet-forming cells and RNA and protein levels for TPM4 was highly significant ( P < 2 –16 and < 6.23 –12 , respectively) ( Figure 8A ), demonstrating that the level of TPM4 is rate-limiting for platelet formation.

A paired t-test confirms that this difference is evidently highly significant (p-value<2.10 -16 ).

This difference is highly significant ( Figure 2A , Figure 2—figure supplement 1 , p-value<2.10 −16 ).

Additionally, no effect of larvae stage was observed for NCR whereas the other factors were highly significant ( p value <2.10 −16 and 1.39.10 −8 for Paraquat concentration and NAC, respectively).

The haplotype (rs2004640T–rs2280714T) involved in both the alternative splice donor site and the elevated expression of IRF5 also had a highly significant association with SLE (pooled, P = 2.11 × 10 -16 ).

This overlap was highly significant as represented by the odds ratio of 38.41-fold over what would be expected by random chance and the p -value < 2.16E-16 (two-sided binomial test).

A comparison of frequencies with Pearson's chi-squared analysis showed a highly significant increase of negative probes in the immune group ( p < 2.2e − 16).

Bartlett’s test of sphericity was highly significant (χ2 = 362.49, df = 11, p < 2.2 × 10 −16 ), confirming that the correlation matrix was not an identity matrix and that the dataset had sufficient inter-variable relationships for factor analysis.

The correlation between the inbreeding coefficients and F ROH were also highly significant (F I: r = 0.71, P = 2.20 × 10 −16 ; F II: r = 0.72, P = 2.20 × 10 −16 ; F III: r = 0.83, P = 2.20 × 10 −16 ).

At the provincial level, the analysis reveals a highly significant difference in case distribution across months ( χ 2 = 169.82, df = 11, p -value < 2.2e-16).

Before this correction, this correlation was strong and highly significant for the 800 μM HFF-TerT sample (Figure 6B , Spearman's ρ = 0.29, P < 2.2 × 10 −16 , asymptotic t test).

The correlation of the concentrations determined by 1 H-NMR and by quantitative methods were highly significant for both the samples of ccDMEM (Pearson: r = 0.99, p = 2.20 * 10 −16 ) and of vcDMEM (Pearson: r = 0.91, p = 2.84 * 10 −6 ).

For each month, the differences between soil and soil + root for COS and CO 2 were highly significant (Kruskal-Wallis rank sum test – p < 2.2e −16 ), with higher CO 2 and lower COS emissions in the soil + root chambers (except for February) (Fig. 3 ).

As with sequence similarity, whereas there is a significant trend for proteins that are among the top 0.5% of co-expressing pairs to share related ligands, (χ 2 = 1.3e3, p < 2.2e-16), pragmatically the effect size is marginal and only 9.3% of the top 15% of co-expressed pairs show any SEA interactions at all ( Fig 1B ).