Excerpts

In fact, among the 291 genes selected for pad4 , 170 genes are also included in those for sid2 : the overlap was highly significant ( p < 2.2 x 10 -16 , Fisher’s exact test).

Visually, H3K4me2 also seemed to be lost at this region, but the major site of enrichment, at the spacer promoter, was unaffected, and the locus-wide correlation remained robust and highly significant (mESC vs. mNPC: R 2 = 0.87, P <2.2 × 10 −16 ).

The overall model was highly significant (likelihood ratio test = 256.5, p < 2.2 × 10−16).

However, of those that overlapped, there was a highly significant enrichment for effect direction concordance (i.e., increased binding with increased accessibility; OR = 18.0, P -value < 2.2 × 10 −16 ), suggesting replication across these distinct studies.

All reported correlations were highly significant ( p < 2.2 × 10 −16 ).

The difference was highly significant ( P -value < 2.2 × 10 −16 ) with cGD averaging 5.8 for populations belonging to the same SDRN and 22.8 for populations that did not belong to the same SDRN.

Correlations between FPKM-corrected expression levels in same-sex replicate pools were highly significant for both the male ( r 2 = 0.830; Spearman’s ρ = 0.906 ; P < 2.2 × 10 − 16 ) and female ( r 2 = 0.869; Spearman’s ρ = 0.928 ; P < 2.2 × 10 − 16 ) pools.

This yielded a highly significant correlation of the average methylation levels between both species (Pearson's correlation rho = 0.611, p < 2.2E−16) indicating, that on a global level, the patterns of gene regulation have been conserved between marmoset and human sperm (Figure 3 ).

We found that both up- and downregulated genes showed highly significant enrichment for association signals ( Z = 9.41, P < 2.2 × 10 −16 for genes downregulated by SUMO-1 depletion and Z = 3.43, P = 4.19 × 10 −4 for genes upregulated by SUMO-1 depletion; Figure 5 D).

Of the 236 transposable elements detected in our RNA-seq data, 97 are differentially expressed in xct-2 , representing a highly significant enrichment (1-tailed Fisher's exact test, P < 2.2e–16; Fig.

Those CpG sites mapping to Alu sequences showed a highly significant trend of increasing methylation from the older to younger elements ( P <2.2x10 -16 , ANOVA), with mean methylation levels (b ± standard deviation [SD]) of 0.72±0.21 for Alu J, 0.74±0.18 for Alu S, and 0.78±0.17 for Alu Y.

Pearson’s Chi-square test was used to analyze whether certain isolated sources had a higher proportion of a specific lineage, revealing highly significant differences ( P < 2.2 × 10 −16 ).

Thus, because there are three possible replacement nucleotides per site, WC sites are ∼66% saturated and nWC sites are ∼90% saturated, and this difference is highly significant ( p <2.20×10 −16 , Binomial test; see Materials and Methods for details).

This difference was highly significant (Mann-Whitney test: U = 2.2×10 7 , P <2.2×10 −16 ).

This deviation from the expected distribution is highly significant by chi-square analysis ( P value = 2.2 × 10 -16 ).

The correlation between the inbreeding coefficients and F ROH were also highly significant (F I: r = 0.71, P = 2.20 × 10 −16 ; F II: r = 0.72, P = 2.20 × 10 −16 ; F III: r = 0.83, P = 2.20 × 10 −16 ).

The excess of GC to AT substitutions is highly significant, indicating non-equilibrium ( p < 2.2 × 1 0 − 16 ).

Further, the concordance of miRNA expression (log normalized) of the common miRNAs was also explored by Spearman correlation and showed a highly significant correlation with rho of 0.81, p<2.2x10 -16 ( Fig 4b ).

The difference was highly significant ( p < 2.2 × 10 −16 ), indicating robust epigenetic dysregulation of the SYTL4 locus in breast cancer ( Figure 2 A).

This reduction was highly significant with a p -value < 2.2 × 10 −16 ( Figure 2 ).

The associations between the type of neoplasm and both the category of lesion and the site of the neoplasm were highly significant at p < 2.2 × 10– 16 (S2).

In the study, two ecologically competitive Functional Groups of golden pompanos were also found, with relative abundance showing a highly significant negative correlation ( R = -0.78, P = 2.2e-16) (Fig. 5 A).

The rescue of genes found differentially expressed in ∆ Firre CLPs by a Firre transgene produced a highly significant result ( P = 2.2e-16, Fisher exact test); however, we note that the widespread changes in gene expression observed in the CLPs from animals only expressing transgenic Firre RNA could also formally contribute to this effect.

In contrast, the overall density distribution of 496 protein kinases in the siRNA screen showed a small but highly significant shift ( p < 2.2 × 10 −16 ) towards synthetic lethality with the peak of the density distribution at 0.95 (Fig. 1 c).

DNMT1-Dependent DNA Methylation in Adult Interneurons Affects Degradative Pathways In stark contrast to the comparison of the 18 months old genotypes, we determined a highly significant overlap ( P = 2.2E-16, Fisher’s Exact test for gene set enrichment analysis; odds ratio = 0.434) of 645 genes between young control and Dnmt1 knockout interneurons, which display significant differences in both DNA methylation and gene expression ( Pensold et al., 2020 ).