Excerpts

Using the Bray–Curtis distance algorithm, PCoA plots were created to visualize beta diversity, which revealed a clear trend of separation among the four sample groups ( p = 0.001, Figure 5 F).

In combined analysis, the addition of trastuzumab to paclitaxel resulted in a significant improvement in DFS (HR 0.52, P < 0.001) and reduction of death by 39% (OS, HR 0.61, P < 0.001) compared to paclitaxel alone.[ 13 ] The efficacy of concurrent versus sequential administration of trastuzumab showed a trend toward improvement in DFS in the concurrent arm; however, sequential was still better than placebo ( P < 0.001).

The physical, psychological, social, and environmental domain score of QOL was found to be better in those with normal activities of daily living (ADL) and having no co-morbidity, and it was also found to be statistically highly significant on applying the “Student t-test” ( P < 0.001) [ Table 5 ].

Regression (E l(0) = 0.756 × ME intake − 504.3) was highly significant ( p < 0.001), and the R 2 value was 0.75.

Furthermore, the correlation values were highly significant for all the items ( p < 0.001).

Similarly, a highly significant positive correlation was found between glycated hemoglobin and plasma leptin concentration (r=+0.9890; n=23; P<0.001), without a negative xy product.

Similar results were obtained for the whole-plaque cohort (stable and unstable plaque), where CCR6 showed a highly significant (P = 0.001) correlation with CCL18 levels (data not shown) when taking all plaques.

Based on likelihood ratio tests, genetic effects were highly significant for both traits ( P < 0.001).

Pearson’s correlation of the higher level of confidence ( p < 0.05 was significant, p < 0.001 was highly significant) was evaluated in the relationship between variables.

For WC-defined phenotypes, both obesity and metabolic dysfunction independently contributed to increased CVD risk relative to MHN: MHO (RR 1.84, 95% CI: 1.23–2.77), MUN (RR 1.58, 95% CI: 1.14–2.20), and MUO (RR 2.22, 95% CI: 1.63–3.04), with a significant trend across categories ( P < 0.001).

Statistically, significant results were signified as p < 0.05, more significant as p < 0.01, and extremely significant as p < 0.001.

CDH1 showed a highly significant upregulation ( p < 0.001*), which was more pronounced than initially characterized.

The analysis revealed a highly significant difference ( p < 0.001), with a Cramer’s V = 0.65, indicating a large effect size.

Accordingly, the relative reduction over time expressed in percentage change from baseline was highly significant ( p < 0.001, Fig. 2 b).

Child–Pugh B, a serum AFP level of >10 ng/mL, and moderate histopathological differentiation showed a highly significant statistical correlation with both LTP development and decreased Loc-PFS ( P < 0.001, P = 0.008, and P < 0.001, respectively).

The variance in allele sizes ( Vp ) is relatively variable among population groups, especially so for the Frequency dataset ( Figure 2A ), and the differences for this last dataset are indeed highly significant (Kruskal-Wallis test, P<0.001 ).

The mean NPAR values were 1.81 (SD = 0.47, Table 1 ), 4.07 (SD = 0.96, Table 1 ), and 11.17 (SD = 6.74, Table 1 ) across the low, middle, and high tertiles, respectively, with highly significant differences between groups ( P < 0.001, Table 1 ).

A repeated-measures ANOVA on vRTs revealed an highly significant difference among stimulated hemispheres [ F (1, 103) = 11.740; p < 0.001] with a right-lateralized hemispheric preference.

In GEO cohort, the Kaplan-Meier curves were drawn ( Figure 4 A), and a markedly significant difference of p < 0.001 was observed between the groups by median cut-off value (Median cut-off value = 0.37).

The CFTR mRNA expression was analyzed by qRT-PCR, and, as shown in Figure 5A , Caco-2/pRS26 cells shows a highly significant (p<0.001) decrease in the CFTR levels (0.58±0.03 a.u.; mean ± SE; n = 10) compared to control cells (0.99±0.06a.u., n = 10).

The odds ratio (95% confidence interval) for mild cognitive impairment was 0.43 (0.39, 0.48) for a successful feet-together test, 0.53 (0.46, 0.60) for a successful semi-tandem test, and 0.63 (0.57, 0.70) for a successful tandem test after adjusting for potential confounders [the p-value for each model was highly significant (all p < 0.001)].

In the final model, when macrovascular comorbid conditions were included, the association between presence of thyroid disorders and total expenditures remained highly significant (beta = 0.19 which translated to 21.4% change in expenditures, P < .001).

In four cases (19%) MCA-P2 was observed before the intervention, and in 17 interventions (81%) thereafter; a highly significant association between IUT and P2 appearance ( p < 0.001).

A two-way (task × body site) repeated-measures ANOVA, with γ as the dependent variable, revealed a highly significant effect of task ( F = 26.35, p < 0.001) with no significant effect of body site ( F = 0.60, p = 0.618) or task-by-body site interaction ( F = 2.52, p = 0.068).

Four weeks after 6-OHDA, highly significant rotational behavior was observed in the MFB lesion cohort when compared to sham MFB group (7.99 rotations/min and 0.10 rotations/min, respectively; P < 0.001).