Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
To further solidify the molecular signatures of the subgroups 1–4, we performed RNA-based single-sample GSEA, which demonstrated robust and highly significant enrichment of the gene sets “stemness”, “synapse assembly”, “gonadotrophs” and “secretory vesicle”, respectively ( p < 0.001; Fig. 2d and Supplementary Data 5a–d ).
a strong trendP<0.0010.0× alphagold
Using our validated histological scoring system, we were able to detect significantly more villous distortion and total inflammation in TNF i∆ARE/i∆ARE → SCID mice compared to wt → SCID mice, and a strong trend towards more chronic inflammation as well (villous distortion index: 4.00 ± 0.00 vs. 2.00 ± 0.00, P<0.001; chronic inflammatory index: 4.5 ± 1.05 vs. 0.75 ± 0.75, P=0.06; total inflammatory score: 9.25 ± 1.19 vs. 3.25 ± 1.25, P<0.05).
highly significantp <.0010.0× alphaqualifiedgold
A paired-sample t-test comparing N1 and MMNm latencies of the left (mean latencies of all subjects: MMNm peak: 164.5 ms, N1 peak: 124.0 ms) and right (MMNm peak: 165.6 ms, N1 peak: 125.6 ms) hemisphere in the perceptual condition reveal a highly significant difference between the latencies of those two components [left hemisphere: t (25) = 5.563, p <.001, right hemisphere: t (25) = 7.132, p <.001], showing that the MMNm peaks are not intermixed with the N1 peaks.