Excerpts

Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10 -9 ).

Voxel values in these clusters were highly significant and two ROIs were created from the binarized clusters with a T statistic threshold T = 7.0 ( p = 1 × 10 −9 ) for the sensorimotor ROI ( Figure 1 B), and T = 5.0 ( p = 2 × 10 −6 ) for the subcortical ROI ( Figure 1 C).

The top SNP rs2290400 is a highly significant eQTL ( P values < 10 −9 ) for two genes, GSDMB and ORMDL3 , in whole blood (as found on gTEX, Fig. 4 ).

However, when 1000 WBC were analysed, blasts were detected in 33/37 (89%) of MDS samples compared with 6/30 (20%) of age‐matched controls, a highly significant difference ( p < 10 −9 ).

These comparisons were also highly significant ( p < 10 −9 for all tests, one-sided Fisher's exact test) for the control participants.

In particular, we found a highly significant correlation between WISP1 and GATA3 (p–value<1x10 -9 ) and a highly significant negative correlation between WISP1 and PPARG (p–value<1x10 -15 ).

One such QTL, lsq4 on chromosome IV, appeared in three different inter-strain crosses as highly significant linkage-mapping peaks for longevity (each P < 10 −9 ) (Ebert et al., 1993 , 1996 ; Ayyadevara et al., 2001 , 2003 ; Shmookler Reis et al., 2007 ).

Sets of 1,049 and 969 genes (out of the total of 14,405 represented on the microarray), were found to be modulated in hippocampus and cortex, respectively, the intersection of the two sets consisting of 619 genes, a highly significant number (P<10 −9 ) ( Figure 5A ).

This increase in responsiveness with depth was highly significant ( R 2 = 0.70, p < 10 −9 , linear regression, n = 35 imaged regions in seven mice; Fig. 2 A ; Table 1 ) and was observed in every animal tested ( Fig. 2 A ; Table 1 ; R 2 > 0.79 and p < 0.04 for all animals, n = 5 regions per animal).

Genome-wide, SLC39A8 (p<4.3×10 −10 ) was one of only 19 genes that passed a combined highly significant statistical association (p<10 −9 ) with tumor aggressiveness [73] .

First, two highly significant ( p < 10 −9 ) SNPs were found in the intron of krishah ( kri ), and two additional SNPs with slightly lower significance ( p < 10 −7 ) were found in the 5′ untranslated region (UTR) of kri ( Figure S3 ). kri is tightly clustered with the genes S6k and mad2 ( Figure S3 ).

The adjacent windows flanking the most significant SNP collectively accounted for approximately 0.5% of the variance in de-regressed breeding value estimates, indicating a modest but highly significant genetic association ( p < 1 × 10 −9 ).

While the alpha-tocopherol had no effects in delaying disability, the selegiline arm show a highly significant effect in delaying the need for L-DOPA treatment over controls (P > 10 –9 ).

Knowing that multigenic cRM represent 10% of all cRM (967/9720), 25/76 (i.e., 33%) corresponds to a highly significant three-fold enrichment ( p < 10 −9 ).

Together these show that four of the genes investigated ( HLA-C, IL12B, TNIP1 and IL23A ) show highly significant differences in expression levels between involved and uninvolved skin (all with p < 10 −9 ).

Differences between the study and control groups in our empirically developed type 3c diabetes index were highly significant (full P value < 0.000000001; Table 2 ).

The difference in medians, 13, is also quite significant ( W = 1075516.5, p < 10 −9 ).

In the infants with confirmed CMPA, there was a highly significant reduction in CoMiSS from 8 (IQR 6–11) to 5 (IQR 3–7) from baseline to visit 2 (p<0.000000001), with a median reduction by −3 (IQR −6 to −1).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

De novo MEME analysis (Figure S2A ) reveals that Round 25 aptamers overwhelmingly share a single, contiguous motif that extends across nearly the entire 40‐nt core, with RTAR and its closest relatives showing highly significant full‐length matches ( p < 10 −9 ), whereas the less enriched clusters display only truncated or offset hits to secondary motifs.

2 A ), as confirmed by the highly significant main effect of window size on MT in a repeated measures ANOVA ( F (8,104) = 176.980, p < 10e-10).

When compared with CON mice, both G HP E and GE mice showed a highly significant reduction of dendritic branching of hippocampal pyramidal neurons (condition effect, P < 1 × 10 −9 ) ( Fig. 4 A ).

The five most highly significant (FDR P = 1 × 10 −9 ) Gene Ontology (GO) terms for biological process relate to immune system activation and regulation (Supplementary Data 12 ).

These remained highly significant (P<10 −9 ) after a conservative Bonferroni correction for three tests (all cases, serous cases, non-serous cases).

It was found that the proportion of the depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (x 2 =770.4 and P =.000000001).