Excerpts

Overall, in the ILR analysis, there was a highly significant difference between cohorts (generalized Wald test; P = 7.234e−10), with greater signature 3 exposure in the early-stage cohort and more signature 4 in the late-stage cohort ( Fig. 4C ).

The differences in fitness observed between the two medium types were highly significant ( p = 7.37E-10).

The result for the same risk allele (T) remained highly significant (Hazard Ratio=2.27, CI = 1.75–2.95, p = 7.8 × 10 −10 ).

For the spotted shins, six significant SNPs were identified, using a significant p -value ≤ 3.94885 × 10 −9 as the threshold, while one extremely significant SNPs was identified using a p -value ≤ 7.8977 × 10 −10 as the threshold.

This model indicated a highly significant effect of gaze, SE = 0.13, z = −6.146, p = 7.95 × 10 -10 , and no effect of shadow, SE = 0.084, z = −1.244, p = .213.

Similarly, the interactions between the two fruit fly species and the temperature regimes were found to be highly significant for adult fecundity (F = 11.85; d.f. = 5, 168; P = 7.97x10 -10 ).

The promoter SNP rs2070895 showed a highly significant association with a 0.057 mmol/l increase in HDL-C per A allele ( P = 8 × 10 -10 ) [ 24 ].

5.a and 5.b ), the difference between strong and weak sites is also highly significant (T-test P value = 8.0 10 -10 for proximal strong sites vs. proximal weak sites).

We identified 527 highly significant (p < 8 X 10 −10 ) pQTLs in 38 (43%) of blood proteins tested.

The non-linear correlation (| r |=0.32) between the sum of free terpenoids and surface conductance was highly significant (adjusted P =8.09e-10).

Moreover, the probability of a right-handed turn (given hereafter as π) based on the GLM was 0.621, a highly significant difference (p = 8.2×10 −10 ) from that expected for random turning (π = 0.5).

GS male ranged between 3 and 12 with a GRR associated to 1 point increase in the score of 1.23 ( P = 2.2 × 10 -6 ; 95% CI 1.13 to 1.34) and GS female ranged between 4 and 14 with a GRR of 1.41 ( P = 1.9 × 10 -5 ; 95% CI 1.21 to 1.65) for a highly significant global test with P = 8.4 × 10 -10 .

Analyses of differential expression of the genes through the FUMA pipeline 37 recapitulated these findings, indicating highly significant (minimum P = 8.4 × 10 −10 ) upregulation in prenatal brain tissue and downregulation postnatally for the first cluster, and vice versa (minimum P = 1.1 × 10 −11 ) for the second cluster, see Supplementary figure 3 .

Meta-analysis of the stage 1 and 2 datasets also produced highly significant evidence of association (rs11136000: p= 8.5×10 −10 , OR = 0.861 and rs3851179: p= 1.3×10 −9 , OR= 0.859, two-tailed, Table 1 ) for CLU and PICALM loci respectively.

This was highly significant ( χ 2 =37.6, P =8.6 × 10 −10 , 95% CI (1.62, 2.53)).

A two-way Scheirer–Ray–Hare test revealed highly significant difference between SWN and no normalization ( p = 8.70 × 10 − 10 ), indicating that the effect of SWN is consistent across methods.

The differential expression in RC disease between these 261 target genes and all non-target genes was highly significant (p = 8.8×10 −10 in muscle and p = 5.5×10 −35 in FCLs) ( Fig.

Individually, these did not reach statistical significance, but when information was combined for all rare variants with an allele frequency of <1%, the results were highly significant (OR = 3.72; 95% CI = 2.38–5.82; P = 8.9 × 10 −10 ).

Although these variants did not reach statistical significance individually, the results were highly significant when they were combined (OR = 3.72; 95% CI = 2.38–5.82; p = 8.9 × 10 –10 ) ( Vallet et al., 2015 ). 22 distinct variants were recently identified in a Belgian population.

Considering the total number of unique genes represented in the arrays as 10500, these overlaps were extremely significant (hypergeometric distribution p = 9E-10 and 2E-09, in that order).

When the Class II and Class III SNPs were included in the logistic regression model, the rs4959039 SNP retained a highly significant association with MS susceptibility ( p = 9.70×10 −10 , odds ratio = 1.52).

A similar evaluation of the CONTROL gene set suggested a highly significant overrepresentation of different intracellular processes, such as extracellular matrix (ECM) receptor interaction ( p = 0.000000000976—BIOPLANET and p = 0.00000000616—KEGG), Beta-1 integrin cell surface interactions ( p = 0.000000437—BIOPLANET), ABC transporters ( p = 0.0000307—BIOPLANET), and various other transmembrane pathways ( Figure 2 b).

These effects are further amplified when adding another variable modification (search strategy D; Figure 2 ; mean 1.95). Because of the bimodal distribution of the target populations even after log(2) transformations, the Kruskal–Wallis test was employed for statistical testing and showed highly significant changes ( p < 10 –9 ) in both score distributions for search strategies C and D.

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

3 , Table 1; supplementary material Table S2 ). The gene ontology analysis of the recent human dataset ( Tsankov et al., 2015 ) included few highly significant terms ( P -value <1×10 −9 ) ( supplementary material Table S2 ).