Excerpts

A t -test comparing scores against 0 demonstrated that this behavioural effect was highly significant ( t = −8.58, p < 10 −9 ).

Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10 -9 ).

The difference in medians, 13, is also quite significant ( W = 1075516.5, p < 10 −9 ).

These comparisons were also highly significant ( p < 10 −9 for all tests, one-sided Fisher's exact test) for the control participants.

In comparison to nevi, all types of melanoma demonstrated highly significant reduction in ciliated cells ( P < 1 × 10 −9 by Tukey test).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

De novo MEME analysis (Figure S2A ) reveals that Round 25 aptamers overwhelmingly share a single, contiguous motif that extends across nearly the entire 40‐nt core, with RTAR and its closest relatives showing highly significant full‐length matches ( p < 10 −9 ), whereas the less enriched clusters display only truncated or offset hits to secondary motifs.

A linear model with age as a covariate showed a highly significant effect of the condition (p < 1*10 −9 ).

In the infants with confirmed CMPA, there was a highly significant reduction in CoMiSS from 8 (IQR 6–11) to 5 (IQR 3–7) from baseline to visit 2 (p<0.000000001), with a median reduction by −3 (IQR −6 to −1).

To simplify the interconnectivity between pathways and gene sets in the Circos plot, we performed filtering of data sets based on (1) limiting the KEGG pathways that are enriched for more than 10 genes ( n > 10) and (2) limiting the gene sets whose enrichment was highly significant (FDR p -value ≤ 10 −9 , the genome wide significance).

The adjacent windows flanking the most significant SNP collectively accounted for approximately 0.5% of the variance in de-regressed breeding value estimates, indicating a modest but highly significant genetic association ( p < 1 × 10 −9 ).

2 A ), as confirmed by the highly significant main effect of window size on MT in a repeated measures ANOVA ( F (8,104) = 176.980, p < 10e-10).

This model performed slightly (although highly significant: P < 1*10 −9 ) better than Model 1.

Knowing that multigenic cRM represent 10% of all cRM (967/9720), 25/76 (i.e., 33%) corresponds to a highly significant three-fold enrichment ( p < 10 −9 ).

The transcriptional changes in CE mice were statistically highly significant (ranging from p < 10 -9 to 10 -5 ), and involved ECM processes related to collagen synthesis/modification/assembly and intracellular signaling via the PIP2/PLCg/DAG/IP3 pathway.

Among all the modules, the turquoise module showed a highly significant association with fibrosis and inflammation levels ( P = 1 × 10 −09 for fibrosis stages and P = 1 × 10 −10 for inflammation grades).

There is one extremely significant correlation (adjusted p value < 10 −9 ) between class size and year level.

An analysis of overrepresented GOs amongst the DEGs (5-fold difference) showed a highly significant enrichment of GO terms ( p < 10E−10), such as ‘neuron migration’, ‘collagen fibril organization’ and ‘anterior/posterior pattern specification’.

Correlation in log fold-change among genes between the two environments was highly significant ( P = 1 × 10 −9 ) but weak ( r = 0.1).

However, when 1000 WBC were analysed, blasts were detected in 33/37 (89%) of MDS samples compared with 6/30 (20%) of age‐matched controls, a highly significant difference ( p < 10 −9 ).

One such QTL, lsq4 on chromosome IV, appeared in three different inter-strain crosses as highly significant linkage-mapping peaks for longevity (each P < 10 −9 ) (Ebert et al., 1993 , 1996 ; Ayyadevara et al., 2001 , 2003 ; Shmookler Reis et al., 2007 ).

In particular, we found a highly significant correlation between WISP1 and GATA3 (p–value<1x10 -9 ) and a highly significant negative correlation between WISP1 and PPARG (p–value<1x10 -15 ).

Genome-wide, SLC39A8 (p<4.3×10 −10 ) was one of only 19 genes that passed a combined highly significant statistical association (p<10 −9 ) with tumor aggressiveness [73] .

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

If we regress the alt-allele frequency in reads from heterozygotes (y-axis of Fig 3B ) onto the estimates for both a and d simultaneously, both are highly significant as positive predictors of allele frequency (p < 10 −9 for each coefficient).