Excerpts

This was highly significant for DHEAS (20 vs. 48 weeks, P = 0.0018) with less significant trends noted for DHEA, T, and ASD ( P = 0.13, 0.041, and 0.049 respectively; Fig. 4D ).

This region shows highly significant evidence of LD variation between Chinese, European (Monte Carlo [MC] p = 0.0018), and African (MC p = 0.0003) individuals, but nominal evidence of variations between Chinese and Japanese (MC p = 0.0107) (ESM Table 12 and ESM Figs 7 and 8 ).

In addition, mean differences between the three rank groups were highly significant for blue-red contrast residuals (Kruskal-Wallis χ 2 = 12.5, p = 0.0018) while being not significant for blue saturation residuals (KW χ 2 = 5.68, p = 0.058) and for red saturation residuals (Kruskal-Wallis χ 2 = 5.45, p = 0.065), although both are close to significance.

However, we found a highly significant correlation ( P = 0.0018) for proteins classified in Pfam-A ( Figure 3 ).

If two genes have a correlation larger than this threshold, 0.80, this correlation is highly significant ( P < 0.0018) based on the Fisher transformation test.

As shown in Table 3 , the model was highly significant for the experimental results with a 95 % confidence level (p-value = 0.0018).

More importantly, the slope of the concentration-effect line was steeper for the thalamus than for the cortex for all frequency bands and the differences were highly significant (p < 0.0018 for the 126–200 Hz range; p < 0.0001 for the other bands.

Body mass showed highly significant ( p = 0.0018) differences depending on spine type and in post-hoc analyses, a significant difference ( p = 0.0230) concerned the comparison of the groups “decreased kyphosis and increased lordosis” and “increased kyphosis and increased lordosis”.

The regression analysis, using λ as the dependent variable and only the guanaco population size (in natural logs, LnNtot ) as the independent variable, was highly significant (AIC = -87.847, p < 0.0018, and F = 11.48,) and the resulting regression equation was λ = 1.6373 – 0.0552 (±0.0163) Ln Ntot ( Table 2 ).

We found highly significant association of prevalence asthma in the existing population with exposure to MIC in terms of distance of residence from the UCIL plant ( P < 0.0018).

A study of the benefit of HSCT showed that the difference in mean overall survival time between those who underwent transplantation (9 allogeneic [allo], 1 autologous) and those who did not was highly significant (31.3 vs 12.8 months; P = .0018). 4 Less information is available on the optimal therapeutic approach to LS-BPDCN specifically.

Despite their relative infrequency (dozens per 24‐h period), fast ripples achieved highly significant group discrimination ( p = 0.0018), demonstrating sufficient statistical power for biomarker utility.

Enzymatic activity assays for SPHK1/2 showed a trend toward reduced activity ( Figure 1 D, p = 0.0018), indicating a decrease in both expression and activity of SPHK in human FRDA fibroblast cell lines.

Kaplan–Meyer curves analyzing tumor engraftment in function of the time from injection, followed by Log-rank (Mantell–Cox test), showed a highly significant difference between FRTL5-Ras-PATZ1-injected mice and their controls ( P = 0.0018; HR = 0.1914; 95% CI 0.01456-0.2701) ( Figure 1 a).

The interaction between transect and host was highly significant ( p = 0.0018), but neither main effects were ( p > 0.07).

When survival data from both Hep3B and SNU-449 models were combined ( Figure 5 H), the Mantel-Cox log rank test generated a highly significant difference between LV-treated and control groups (p = 0.0018).

Subgroup analysis In the subgroup analysis of patients who had received first-line treatment according to the TKI strategy, the PFS still exhibited a highly significant difference between the two groups (P=0.0018) ( Figure 4 ): the mPFS was 4.0 months (95% CI, 3.6–6.8 months) in the regorafenib group and 10.0 months (95% CI, 7.2–32.4 months) in the combination group.

Functional richness (FRic) showed an increasing trend across all bays in both spring and fall (logFRic ~ Year, p = .0018 and p < .0001 for spring and fall, respectively, Figure 2a ).

When we expanded t tests to include all 35 comparisons—and, like above, corrected for 35 comparisons—we found a significant difference in inference scores between students who exhibit mastery on question 5 and students who do not ( t = 3.41, p = 0.0012, d = 0.88), as well as a marginally significant difference in these students’ induction scores ( t = 3.26, p = 0.0018, d = 0.84; the Holm-Bonferroni cutoff is p = 0.00147).

Aspirin administration was associated with a significant reduction of PD‐related complications < 32 weeks, with a significant trend for a simultaneous increase of PD‐related complications ≥ 32 weeks (test for trend, p value = 0.0018, Table 1 , Figure S5 ).

In particular, the enrichment of the ZRS in comparison to flanking non-ZRS regions is highly significant (amplicons “b” to “d” versus “a” and “e”; p = 0.0018), while the variability among the three ZRS amplicons is not significantly different.

These differences were highly significant (0.0001 < P < 0.0018) in the C57BL/6, 129S6 and BALB/c backgrounds, but less so in the CBA/Ca background (0.017 < P < 0.048), and not significant for the specific comparison of the CBA/Ca homozygotes at 32 and 16 kHz ( P = 0.11).

In adjusted Cox regression analysis, children 6–10 years had a higher mortality risk compared with infants but did not reach statistical significance (adjusted HR 7.33, 95% CI 2.09–25.68, p = 0.0018) (Table 3 ). 4.

3A,D : F (2,26) = 2.51, p = 0.10) was a nonsignificant trend, the number of cFos-positive cells was significantly decreased in the CPu (Fig. 3B,E : F (2,30) = 7.871, p = 0.0018) and the dorsal hippocampus (CA3) (control: 100 ± 10.3, PS: 80.7 ± 11.1, ES: 59.5 ± 9.7; F (2,30) = 3.761, p = 0.0349) of ES mice compared to controls, with a similar non-significant trend observed in the dorsal DG (Fig. 3C,F : F (2,30) = 3.217, p = 0.0542).

Highly significant differences were found among the dominant genera ( H = 54.76, p = 0.001816) in the studied ponds.