Excerpts

Interestingly, there was a highly significant positive correlation ( r = 0.7575, P = 0.0017) between GHSR1a and ghrelin ( Fig. 5A ) and also between GHSR1a and SERCA2a ( r = 0.7154, P = 0.0040) ( Fig. 5C ).

There was a highly significant decrease in tumor volume in the NTP-treated group as compared to the untreated control group ( p = 0.0017) ( Figure 1C ).

There was a highly significant difference in CN between the three conditions tested for all samples (Friedman test p = 0.0017 for EIF2C1 and 0.0046 for TSC2 ), with a significant pairwise difference between the original and Puregene CN values after Dunn’s multiple comparison correction (p = 0.0045 and 0.0141 respectively).

2 B); this association was highly significant (correlation between GABA and average normalized suppression indices r = 0.88, p = 0.0017).

g ba −/− immortalized neurons showed a severe deficiency in enzyme activity (3.40±0.36% relative GCase activity, mean±s.e.m.) compared with gba +/+ immortalized neurons (93.44±12.26% relative GCase activity), which was highly significant ( P =0.0017) ( Fig. 3 C).

Due to a 3- to 4-fold upregulation of CASQ2 4 weeks after TAC, this difference is not significant by 2-way ANOVA, but highly significant by Student’s t-test (p = 0.0017).

The pseudo-absence selection method had a highly significant (ANOVA, p = 0.0017) effect on model mean AUC values, but the interaction between model type and selection method was insignificant.

When decade of music was included in the analysis, a linear contrast found a quite significant decreasing effect of birth cohort [ F (1,54) = 10.9, p = 0.0017] on how much they were listening to music alone.

Three and four month in-situ explants had highly significant differences in failure load between measurements close and distant to the osteotomy line: p=0.0017 (the region of maximum load in-situ ).

PC exhibited a decreasing trend with an increase in the BMD quartile (Q1: 242.55 ± 56.12; Q2: 243.75 ± 58.61; Q3: 243.20 ± 58.40; Q4: 238.38 ± 56.79; P = 0.0017).

Moreover, significant changes were observed in several parameters: the proportion of subjects with FVC < 80% showed a highly significant decrease ( p = 0.0017).

Similarly a highly significant correlation between incidence of CD and lactase persistence (r = -0.655, p = 0.0017) was reported in an observational study encompassing data from 20 countries [ 19 ], whilst Shrier et al [ 20 ] reported a reduction in CD risk with increasing prevalence of lactase non-persistence in a review of global population data.

Primary outcome (secondary hyperalgesia areas) Baseline data Data consistency during Session 1 vs Session 2 ( Figure 2B ) was examined by ICC’s (0.85 [0.64–0.94]) and by comparisons of baseline assessments using simple paired sample tests demonstrating a highly significant difference in baseline assessments between the sessions (Wilcoxon: P =0.0017).

In a multivariate regression analysis, utilizing baseline CA19-9, and baseline ctDNA KRAS as continuous variables, along with the co-variates of interest, stage, gender (sex), and baseline European Cooperative Oncology Group (ECOG) performance score, ctDNA KRAS remained highly significant for TTP (HR = 1.45; 95% CI 1.15–1.83, p = 0.0017), while baseline CA19-9 was less significant (HR = 1.27; 95% CI 1.03–1.58, p = 0.0284) along with sex (HR = 0.79; 95% CI 0.63–0.99, p = 0.0400) (Table 3 ).

We found that, in the BAC region of overlap across the two dosage levels (0–0.025%), as expected, linear regression revealed a large and highly significant elevation in the y ‐intercept estimate for the lower‐dose condition (Δ = +15.6%, F 1,23 = 12.67, P = 0.0017).

As expected from the definition of the 0.1% threshold, it was highly significant to discriminate PFS between both groups of patients (Figure 3 , p = 0.0017) and although OS was better for the HFLC‐low group, the difference was not statistically significant.

We performed Gene Set Enrichment Analysis (GSEA) on the differentially expressed genes and found that, compared with the NC group, the OGD + VK1 group showed a trend toward suppression of the cellular response to reactive oxygen species pathway ( p = 0.0017; p.adjust = 0.1457).

The similarly sized (.354 ≤ r ≤ .460) and highly significant (.00003 ≤ p ≤ .00171) correlations suggest that all automated approaches produced scores that were good approximations of the manual codes.

In addition, because CD4T and CD8T showed nominally significant associations with hsCRP, we also tested these interactions in chronic pain and found that CD4T, but not CD8T, positively interacted with hsCRP (beta=2.5, p=0.00175; n=820; Figure 1E ) in chronic pain.

We were able to demonstrate a highly significant difference ( p = 0.00175).

Unknown genera in the hypersaline ( p value = 2.01E − 13) and polar ( p value = 2.41E − 9) habitats had significantly higher hub scores than Known genera, whereas in the deep sea environments the Unknown nodes were marginally significant ( p value = 1.77E − 3).

Kaplan–Meyer curves analyzing tumor engraftment in function of the time from injection, followed by Log-rank (Mantell–Cox test), showed a highly significant difference between FRTL5-Ras-PATZ1-injected mice and their controls ( P = 0.0018; HR = 0.1914; 95% CI 0.01456-0.2701) ( Figure 1 a).

However, we found a highly significant correlation ( P = 0.0018) for proteins classified in Pfam-A ( Figure 3 ).

A study of the benefit of HSCT showed that the difference in mean overall survival time between those who underwent transplantation (9 allogeneic [allo], 1 autologous) and those who did not was highly significant (31.3 vs 12.8 months; P = .0018). 4 Less information is available on the optimal therapeutic approach to LS-BPDCN specifically.

If two genes have a correlation larger than this threshold, 0.80, this correlation is highly significant ( P < 0.0018) based on the Fisher transformation test.