Excerpts

Figure 6c shows that 5/6 of the predicted classes of compound had clear effects on ECM organisation, with MEK and Hsp90 inhibition having particularly strong effects ( Supplementary Figure 6b shows additional drugs with the same molecular targets); in contrast only 4/21 of a ‘control’ set of compounds had any effect ( Supplementary Figure 6c ), which is a highly significant enrichment p<0.005 (Chi-square).

Analyzing the trend in the different age groups there was a highly significant statistical difference (p < 0.005).

When using individual subject data, the effect for the co-occurrence model in these ROIs is relatively small but highly significant (DPFC and IPS: z > 0.04, both p < 0.005, Fig 2B ).

Conversely in RA this percentage was higher in males than in females in both studies but the difference was highly significant here (p<0.005) but less so in Meyer and colleagues (p = 0.043).

Analysis of latency of uncertainty coding In standard uncertainty tasks, each neuron’s smoothed normalized activity aligned at CS onset was further smoothed with a 101 ms causal boxcar kernel and then tested at each millisecond starting 50 ms after CS onset for whether it met the following criteria: (1) highly significant ROC area for distinguishing pooled data from uncertain reward CSs from the certain 0% reward CS (p < 0.005), (2) highly significant ROC area for distinguishing pooled data from uncertain reward CSs from the certain 100% reward CS ( p < 0.005); (3) both ROC areas have the same “sign” (i.e., both > 0.5 indicating activation by uncertainty or < 0.5 indicating inhibition by uncertainty).

All other pairwise comparisons were highly significant ( p < .005, save for 115 and 125 BPM, p = .016, and 120 and 130 BPM, p = .012).

Among the 32 subjects in the bryostatin treatment group in the Moderate Stratum Cohort in the #203 study, we found a difference = 4.1 points (with imputed data) in the mean SIB at week 13 from baseline (See Table 5 below), a result that is highly significant ( p = 0.005).

In group I there was a highly significant difference in hemoglobin level, ALT and AST before and after 28 days from the start of treatment with DAAs (P< 0.005, 0.0001, 0.0001 respectively).

All the regression models for all measurements were shown to be extremely significant (p<0.005), so the p value was not presented for each model in Table 1 , 2 .

The TD was found to exhibit a highly significant impact on OS, which was 4.3 months (3.7-5 months) versus 18.2 months (8.5–28.7 months) for patients with a TD below 205 Gy or over 205 Gy, respectively ( p = 0.005).

The final regression model was highly significant (F [3,52] =4.806, p=0.005), the adjusted R-squared value was 0.172, and each predictor (age, gender, and dose of sodium thiopental) was significant (p=0.05).

Of note, we observed a significant trend toward normalization of the B-cell compartment with significant increases in (i) the percentages of CD19 + CD27 + memory B-cells ( p = 0.005) and of non-class-switched memory B-cells ( p = 0.030) and (ii) class-switched memory B-cells (absolute count and percentage, p < 0.0001) in resolved cGVHD.

After Greenhouse-Geisser correction, a marginally significant interaction time × sex was found ( F (1.59, 1) = 6.15, p = 0.005, η p 2 = 0.07; Fig. 2 ).

However, the test for positive selection at individual codon sites (PAML model M1 and M2) was highly significant (χ 2 = 10.66 with 2 df , p = 0.005), identifying two codons subject to selection (dn/ds > 1), codon #1 (dn/ds = 3.71; p = 0.015) and codon #16 (dn/ds = 3.65; p = 0.034; see Figure 1 ).

In one subject (B.M.S.) for one parameter ( n ) this was not significant ( p = 0.25); the eight other cases were highly significant ( p < 0.005 in all cases).

In our cohort of 23 nuclear/cytosol fractionated AML patient samples, we observed a highly significant degree of correlation (Spearman Rank R=0.63, P <0.005) between the relative nuclear-localized (as a proportion of total) β-catenin protein and relative nuclear-localized (as a proportion of total) LEF-1 protein ( Figure 5B and C).

The correlations between the two PEth homologues were highly significant and increased during the study: rs = 0.705 ( p = 0.005, n = 14) at baseline and rs = 0.918 ( p = 0.000, n = 21) after 2 weeks of alcohol consumption.

Ten QTL were highly significant at P < 0.005 level.

Results Multivariable analysis revealed that out of several variables studied six dichotomized features: namely: cigarette smoking, lack of chemotherapy, palliative doses of radiotherapy, high OPN concentration, advanced T stage and high VEGF concentration had a highly significant ( p < 0.005) and independent influence on overall survival in the group of 337 patients.

The results of the performed regression analyses display the existence of a statistically significant, and a marginally non-significant association of the reported SEF prevalence with dominance ( p = 0.005), and type of data ( p = 0.060), respectively (Table 3 ).

Clinical parameters such as KPS score, WHO-PS, NPS scale, PIGNATTI index, and MMSE were found to be significantly correlated with outcome; among these, preoperative and postoperative KPS score showed extremely significant correlation with respect to survival and outcome ( P < 0. 005) [ Table 3 ].

5 A and C ) were related to 1) the relative increase in siRNAs derived from LTR-retrotransposons—notably from Gypsy when comparing the S5 generation to MPV and S1 ( P < 0.01 and P < 0.005, respectively) and 2) the highly significant decrease in other TE-siRNAs in the S1 generation compared with MPV ( P < 0.005 for siRNAs derived from LINEs and P < 0.05 for siRNAs derived from SINEs or class 2 Terminal Inverted Repeats (TIR)-transposons).

A fixed‐effects meta‐analysis of rs10183914 in the discovery and validation cohorts identified a highly significant estimated OR of 1.34 (95% CI 1.09–1.64; p = 0.005).

The values of F/Wald-statistics are highly significant (p<0.005), which reveal that our models are good-fit.

After controlling for confounding factors, there was a strong evidence of a decreasing trend in care seeking with increasing distance to care ( P ≤ 0.005).