Barely Significant

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highly significantP < 0.010.2× alphaqualifiedgold
Correlation analysis Based on the Pearson correlation analysis ( Pan et al., 2024 ) of 23 quality traits in frost mulberry leaves from 21 mulberry varieties ( Figure 1 ), 16 pairs of indicators exhibited highly significant correlations ( P < 0.01), while 12 pairs showed significant correlations ( P < 0.05).
highly significantP < 0.010.2× alphaqualifiedgold
Further multiple linear regression analysis reveals that when both “contact angle” and “particle size” are included as independent variables, the effect of contact angle is not statistically significant ( P > 0.05), whereas particle size remains highly significant ( P < 0.01).
highly significantp < 0.010.2× alphaqualifiedgold
The association of the relative change in (the logarithmically transformed) total lesion glycolysis (∆TLG) with pathologic response was highly significant ( p < 0.01) and this parameter yielded the highest discriminatory ability (AUC 0.74).
extremely significantp < 0.010.2× alphaqualified
In addition, as fluctuation in the temperature of the storage environment increased, the correlation between some indicators was enhanced, for example, the correlation between ADP and some indicators (such as EL, MDA, O 2 · − , H 2 O 2 , etc.) changed from significant ( p < 0.05) to extremely significant ( p < 0.01) ( Figure 8 A–C).
highly significantp < 0.010.2× alphaqualifiedgold
AMOVA revealed highly significant differentiation ( p < 0.01) between groups of accessions grouped according to their germplasm provider, population type, country of origin, and region of origin, accounting for 19%, 17.5%, 38%, and 27% of the total genetic variation, respectively ( Table 3 ).
highly significantP ≤ 0.010.2× alphaqualifiedgold
The obtained results were analyzed using the Excel-Stat 2019 software for determination of the spatial and temporal variations by analysis of variance using the one-way ANOVA test (alpha = 0.05) which was also used for determination of the probability values ( P-values ); significance levels of tests were taken as significant when P ≤ 0.05 and highly significant when P ≤ 0.01.
a borderline significant trendp = 0.010.2× alphagold
1 Mean difference −0.62 × 10 − 3 (95% CI −1.25 to 0.01) × 10 − 3 , p = 0.06, indicating a borderline significant trend favoring darbepoetin; Fig. 2 Mean difference −0.83 × 10 − 3 (95% CI −1.46 to −0.19) × 10 − 3 , p = 0.01, demonstrating a statistically significant advantage for darbepoetin Fig. 3 Mean difference −1.45 × 10 − 3 (95% CI −2.06 to −0.83) × 10 − 3 , p < 0.00001, indicating a highly significant superiority of darbepoetin Collectively, these findings suggest that, under most study conditions, darbepoetin is likely to be more effective than short-acting epoetin in achieving or maintaining target hemoglobin concentrations.
highly significantp < 0.010.2× alphaqualifiedgold
We further performed a cross-Correlation-Analysis with 16S rRNA sequencing and metabolomics data, showing highly significant correlations ( p < 0.01) between KYNA levels in cecal contents and multiple bacterial taxonomic units ( Desulfovibrionales , Mucispirillaceae ) that were enriched in NRF mice (Fig. 6a ). suggesting KYNA KYNA is produced by abnormal enrichment of gut microbiota in NRF mice.