Excerpts

First, we found SYT1 as a near-significant ( P = 3 × 10 − 6 ) top sweep candidate in the YRI population, featuring both m ^ = 2 sweeping haplotypes and m ^ = 2 MLGs involved in the sweep at the window of maximum signal for K = 20 ( fig. 5 and supplementary fig.

Additionally, the relationship between observed nested PCR band intensities (i.e., very strong, strong, weak and negative) and ATX-a ELISA values was also found to be highly significant ( p < 0.000003 and p < 0.02, Tukey’s honest significant difference (HSD) test and ANOVA) (Fig. 4b ).

Analysing this group against the remaining groups combined was highly significant ( P =0.000003) ( Figure 4d ) and was an independent prognostic factor ( P =0.0003, HR=0.1, 95% CI=0.0–0.4) ( Table 2 ).

Nominally significant associations were observed for the following health risk factors: Telomere length was longer among girls compared to boys (p = 3 e–06) and among children of high affluence families (p=0.008).

A combined LDS-gene burden analysis was performed, revealing a highly significant association (4.5% vs 1.5%; p=0.000003).

This difference is highly significant ( t = 5.1, p = 3×10 −6 ).

Statistical analysis using the Kruskal–Wallis test revealed a highly significant overall difference among the groups ( p = 3 × 10 −6 ).

p21 prevalence differed significantly between most nevus and melanoma categories, and the overall trend with progression was highly significant ( r = 0.528, P = 3 × 10 −6 ; Table 1 ).

Conversely, the recA generalized linear model showed little difference to the null model ( p -value = 0.93), whereas that of pstS showed a highly significant difference ( p -value = 3.08×10 −6 ) from the null model ( Figure 4 ).

The correlation between phenotypic and carbapenemase genes detection was highly significant for K. pneumonia, E. coli, P. aerugnosa and A. baumannii ( P = 0.0000031; P = 0.00079; P = 0.015; P = 0.02, respectively) while for ESBL genes correlation was only significant for P. aerugnosa ( P = 0.038) Table 3 .

After adjustment for age, sex, smoking status, use of antihypertensive medications, and HDL-C levels with the Bonferroni correction, participants carrying the minor alleles of the rs2043085 and rs1532085 genotypes exhibited a significant trend of higher LAP ( P = 3.2 × 10 −6 and 8.1 × 10 −6 for rs2043085 and rs1532085, respectively) and VAI ( P = 4.3 × 10 −6 and 5.2 × 10 −6 for rs2043085 and rs1532085, respectively).

When correlating with pathological biomarkers, the SI showed strong correlations with all the measurements ( P ≤ 3.2e−6), with the weakest correlation observed for diffuse plaque, which was still highly significant ( P = 3.2e−6) ( Fig. 2C ).

This overlap of DMRs between replicated experiments is highly significant ( P -value = 3.3 × 10 −6 ).

To assess this possibility, we compared delta divergence from the consensus between neighboring ERVs (|neighbor_1_div—neighbor_2_div|) in ERV hotspots to other regions of the genome and report a significant trend in the opposite direction (Mann Whitney U, P = 3.317e−06), suggesting that SD is not the primary contributing mechanism to ERV hotspot formation.

There were about 146/275 (53%) of the CPC-1 up- and downregulated genes under amino acid starvation exhibiting rhythmicity, indicating a highly significant enrichment of CPC-1 regulated genes as clock-controlled genes (p = 3.341905e−06, hypergeometric distribution test).

In addition, CpG06500161 was also significantly associated ( P = 1.60 × 10 −9 ) with HOMA-IR, while CpG1881899, also a CpG site in ABCG1 , was marginally significant for that phenotype ( P = 3.36 × 10 −6 ).

Multivariate SD–gene interaction analysis in participants of african descent In the Yale-Penn participants of African descent, we observed the HGF gene survived Bonferroni multiple testing correction for the StructLMM interaction test ( p = 1.08 × 10 −6 ) and approached significance in the association test ( p = 3.39 × 10 −6 ).

Using Fisher's exact test, the association between claudin-4 and CA125 positivity was shown to be highly significant (P = 3.4 × 10 -6 ), confirming the lack of independence between these two markers.

The overall joint test of the SSTR5 haplotypes on presence of acromegaly (comparing acromegaly patients and control II group) was highly significant ( P =3.4×10 −6 ).

The genome-wide analysis of TNE with CPD exhibited reduced marginal significance ( p -values < 3.4E-6), reduced numbers of variants in the chr15q25.1 and chr19q13.2 regions, and a different region with the most variants selected (chr10q25.3).

The correlation remained highly significant in most cohorts of each cancer type ( R = 0.73, P = 3.4 e‐06) (Fig. 2E and Fig.

Following variable selection including only those significantly contributing to the class difference the multivariate difference between Groups was highly significant (p = 3.5 ∗ 10 − 6 ).

Mediation analysis evidenced a highly significant direct effect of total HA experience on LE (with more than 1 point increase in EEAS per log(years in HA experience) (1.051 (SE = 0.227), z = 4.6, p = 3.5 × 10 −6 ), a significant but weaker indirect effect mediated by better ear hearing threshold (0.216, (SE = 0.072), z = 3, p = .003 ) that represented only 17% of the effect seen (total effect estimate: (1.267 (SE = 0.22), z = 5.73, p = 10 −8 ).

The correlation between RDW and AML risk remained highly significant when controls without ARCH-PD were excluded from the analysis (P=3.5 x 10 -06 , Wald test with Bonferroni multiple testing correction, Extended Data Fig. 5b ).

Variants in locus 6q24.3-q25.1 reached marginal significance (rs9390543, SASH1 , P = 3.56 × 10 –6 , OR 0.75) in CCSS and significance when meta-analyzing with SJLIFE ( P = 2.02 × 10 –8 , OR 0.75).