Barely Significant

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highly significantP ≤ 0.00010.0× alphaqualifiedgold
Clinical Pharmacology disease management patient‐generated online data Pharmacometrics Psychopharmacology For major depression, the same relationship was even more pronounced, with an average loss of 0.4 rating points out of 10 per decade since the FDA approval (corresponding to a Pearson's R of between −0.56), highly significant for all drugs with at least five reviews ( P ≤ 0.0001), at least 10 reviews ( P ≤ 0.0001), or at least 20 reviews ( P = 0.0002) (Table 2 ).
highly significantp < 0.00010.0× alphaqualifiedgold
Age is also highly significant (younger p < 0.0001 in univariate analysis), as is the prevalence of socioeconomic disadvantage in the local area where respondents live (less disadvantage p = 0.0006 in univariate analysis), but both become non-significant in multivariate analysis, i.e. when analysed in the context of the other independent variables.
highly significantp < 0.00010.0× alphaqualifiedgold
As shown in Additional file 1 : Figure S1, the correlation of eGDR calculated using this formula with glucose disposal rate (GDR) measured with euglycaemic-hyperinsulinemic clamp in 140 T2D patients was highly significant ( r = 0.624; p < 0.0001); moreover, it was higher than that of Homeostasis Model Assessment – Insulin resistance (HOMA-IR) in the 85 patients with calculable values ( r = 0.441; p < 0.0001) and similar to that reported in the validation study in T1D individuals [ 25 ].
highly significantp <0.00010.0× alphaqualifiedgold
When considered separately, at least the larger cell bodies show a highly significant arrangement, with all cell bodies occurring within the leg-bearing region (Table 1 ; χ 2 65.80, df 9, p <0.0001), whereas the small RFamide-LIR cell bodies are distributed without any significant differences in their arrangement along the nerve cord (Table 1 ; χ 2 5.176, df 9, p 0.8187).