Barely Significant

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highly significantp < 0.00010.0× alphaqualifiedgold
HDL-C Patients that died had a highly significant lower serum HDL-C on day 1 of ICU admission (p < 0.0001, meta-analysis t-distribution) with a pooled mean difference of −7.06 mg/dL (95% CI −9.21 to −4.91 mg/dL) across 17 studies with 1542 participants 17 , 20 , 22 , 31 , 32 , 34 , 36 , 37 , 40 , 41 , 43 , 45 , 46 , 47 , 48 , 50 , 51 ( Fig. 3 ).
highly significantp ≤ 0.00010.0× alphaqualifiedgold
The level of significance ( p -value) for each test is indicated in the figures using the following notation: ns ( p > 0.05)—non-significant, * (0.01 < p ≤ 0.05)—significant, ** (0.001 < p ≤ 0.01)—very significant, *** (0.0001 < p ≤ 0.001)—highly significant, and **** ( p ≤ 0.0001)—extremely significant. 5.
highly significantp < 0.00010.0× alphaqualifiedgold
A significant increase of several amino acids including phenylalanine (Phe, p < 0.01), tryptophan (Trp, p < 0.001), and tyrosine (Tyr, p < 0.0001), as well as isoleucine (Ile, p < 0.05), glutamate (Glu, p < 0.05), glutamine (Gln, p < 0.05), and glycine (Gly, p < 0.05) was observed, whereas a highly significant ( p < 0.0001) decrease in cysteine (Cys) was measured.
highly significantP < 0.00010.0× alphaqualifiedgold
To see if whole tumour GREM1 expression correlated with this classification we used The Cancer Genome Atlas RNA-Seq data to match sporadic tumour samples to the published CCS1, CCS2 and CCS3 subtypes and found a highly significant correlation between high GREM1 expression and CCS3 subtype tumours ( P < 0.0001, ANOVA) ( Fig. 5d ).