Excerpts

We initially compared the two genotypes including all the trials, and we observed a strong trend towards increased latency in juvenile Scn2a +/− female mice (two‐way repeated measure ANOVA on both days, F (4.177, 154.5) = 8.796, p < 0.0001 for trial effect, F (1.37) = 3.895, p = 0.056 for genotype effect and F (5.185) = 0.4196, p = 0.83 for genotype × trial interaction), but no difference in adult mice (two‐way repeated measure ANOVA on both days, F (3.460, 86.51) = 4.052, p = 0.0068 for trial effect, F (1.25) = 0.9008, p = 0.35 for genotype effect and F (5.125) = 0.51, p = 0.7693 for genotype trial interaction).

There were highly significant differences ( P < 0.0001) among all groups regarding almost all postoperative ocular aberration components.

Compared to age-matched controls, the whole cohort of patients had highly significant higher levels of both calgranulins (P < 0.0001 and P = 0.0030, respectively).

Results Highly significant ( p = 0.0001) increase in cycle threshold qPCR and decrease in the mean concentration of EBV DNA (p = 0.0001) were observed in serum samples, but no significant changes were observed in saliva.

The neural response change at the target rate of 4 Hz is highly significant (bootstrap across participants, p <10 −4 ) ( Figure 3A ).

However, due to the extensive variance in fingertip force between the participants across all 13 stimuli, the explained variance was small while still highly significant ( R2 = .062, F (1,257) = 8.49; p < .0001).

Two-way ANOVA revealed highly significant main effects of both cell type (F 1,14 = 89.42, p < 0.0001) and ZnO concentration (F 3,14 = 11.00, p < 0.001), with no significant interaction effect (F 3,14 = 1.25, p = 0.326), indicating that the differential sensitivity pattern remains consistent across all tested concentrations.

A repeated-measures ANOVA on the transformed LHIPA revealed a highly significant main effect of task, F ( 1 , 29 ) = 458.076 , p < 0.0001 , with a large effect size ( η 2 = 0.827 ).

A Permanova analysis confirms that there were highly significant differences in the multivariate CHC profiles across the different treatment groups ( F = 37.76, p < 0.0001).

The 6-OHDA lesioning ( n = 8) caused a near-complete and highly significant (96.8 ± 1.8%, Two-Sample t -test, p < 0.0001) abolishment of DAT at the level of the CPu ipsilateral to the lesion in experimental cohort 1.

This difference was highly significant (p < 0.0001; ANOVA test with Bonferroni post-hoc).

One-way ANOVA confirmed a highly significant difference in the percentage of Th17 cells across groups, F (3, 16) = 59.41, p < 0.0001, R 2 = 0.92.

communis had a highly significant effect on a wide range of bacterial groups independent of the watering regime as obtained with an analysis of differential abundance (ALDEx2) ( P < 0.0001) (Supplementary Figure S2 , S3 , Table S2 ).

domesticus sub-species ( Table S2 ) based on highly significant discrimination of the modern sympatric species (MANOVA, Wilk’s Lambda = 0.087, df1 = 13, df2 = 26, F = 20.78, P <0.0001).

anxiety disorders showed an AUC of .68 ( p < .0001), with sensitivities of .90/.87 and specificities of .34/.44 for ASD using the recommended SCDC cut-offs. SRS and SCDC total scores differed highly significant between groups ( F 2/469 > 54.9, p < .0001, eta 2 > .19), with ASD scoring higher than CLIN, and CLIN scoring higher than TYP ( p < .0001) in both scales.

However, according to LDMs including data from all study time points, there were highly significant differences in microbiota composition ( p = 0.0001) across the study period.

This pattern was also true of the linear trend where this level of association was particularly apparent in relation to the high intensity angry expressions, such that the mean number of FRAXE repeats showed a trend - the more FRAXE repeats, the more likely was the boy to recognise extreme anger (P<0.0001).

The superior performance of SHuffle strains ( Fig 1 ), supported by highly significant ANOVA results (F (11,24) = 45.32, p < 0.0001), validates recent emphasis on engineered redox systems for disulfide-rich proteins [ 44 ].

The difference in spatial selectivity between the two brain areas was highly significant ( p < 0.0001).

Firstly, the gesture-only conditions (blurred, pointing, give-me gestures) were statistically investigated in a 2-way ANOVA (Time window × Gesture type) calculated across the three time windows, which revealed a highly significant interaction (F(4, 96) = 8.47, ε = 0.66, p = 0.0001, η p 2 = 0.26).

For the 170 workers with measured TCDD levels greater than 10 ppt, the Spearman correlation between their cumulative exposure scores and the back- extrapolated lipid levels was highly significant (rho = 0.65, p = 0.0001).

Associations of biomarkers with all-cause mortality in X69 Highly significant associations for 10 of the evaluated biomarkers (all except bilirubin) with all-cause mortality were observed in X69 ( P <0.0001; Fig 3 and Table 2 ) when they were evaluated one by one adjusting for classical risk factors (age, sex, glucose, systolic blood pressure, BMI, total cholesterol and smoking).

In the entire PRDM9 protein of 894 amino acids, only 96 amino acids are in a DNA-binding turn-helix region (8 in each of 12 ZF domains), indicating a highly significant enrichment of nonsynonymous SNPs in turn-helix residues (24/31 vs. 96/894, P<0.0001 by Fisher's exact test).

Comparing the results of retinal thickness values measured in the whole macular area (6 × 6 mm) and fovea (automatically selected by the instrument software) we also observed highly significant differences between the groups: the whole macular area ( p < 0.0001) and fovea ( p = 0.02).

Inclisiran produced a mean LDL-C reduction of −46.5% at day 150 versus +1.4% with placebo and −11.2% with ezetimibe; the between-group differences were large and highly significant (inclisiran vs. placebo −47.9%, and vs. ezetimibe −35.4%; P < 0.0001 for both comparisons) [ 30 ].