Barely Significant

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a significant trendP <0.00010.0× alphagold
The mean (standard deviation) number of days from vaccination to onset of symptoms for influenza-positive subjects was 119 (21) compared with 109 (32) for influenza-negative subjects, with a significant trend for increasing risk ( P <0.0001) of a positive influenza result in the unadjusted analysis considering days elapsed since vaccination to onset of symptoms ( Table 4 ).
highly significantp < 0.00010.0× alphaqualifiedgold
Treatment with higher dosages showed a dose-dependent recovery in the sperm count, with the human equivalent dosage showing a highly significant increase ( p < 0.0001) in the sperm count compared to the fertility impaired group, but this number was only 16.5% of the sperm count in the healthy control group.
highly significantP < 0.00010.0× alphaqualifiedgold
Migration assays revealed that PRF caused a highly significant ( P < 0.0001) and higher than 15-fold increase (19.3-fold for DF, 18-fold for PDL, and 17.1-fold for AB) in the number of migrated cells when compared to DMEM medium, while platelet-poor plasma (PPP) only caused a moderate 5–10-fold increase in the number of migrated cells (7.8-fold for DF, 5-fold for PDL, and 7.1-fold for AB). 3.3.
a strong trendp < 0.00010.0× alphagold
We initially compared the two genotypes including all the trials, and we observed a strong trend towards increased latency in juvenile Scn2a +/− female mice (two‐way repeated measure ANOVA on both days, F (4.177, 154.5) = 8.796, p < 0.0001 for trial effect, F (1.37) = 3.895, p = 0.056 for genotype effect and F (5.185) = 0.4196, p = 0.83 for genotype × trial interaction), but no difference in adult mice (two‐way repeated measure ANOVA on both days, F (3.460, 86.51) = 4.052, p = 0.0068 for trial effect, F (1.25) = 0.9008, p = 0.35 for genotype effect and F (5.125) = 0.51, p = 0.7693 for genotype trial interaction).
highly significantp < 0.00010.0× alphaqualifiedgold
For VAY, all linear effects (X 1 2 , X 2 2 , X 3 2 ) and interaction terms were highly significant ( p < 0.0001), with the linear term of extraction time (X 1 ) in UAE and the liquid–solid ratio (X 2 ) in WBE displaying particularly significant. 2.2.2.
highly significantP < 0.00010.0× alphaqualifiedgold
Linear regression of seasonal curve shape against methodological score was highly significant ( r 2 = 0.3, F = 16.9, P < 0.0001, test for normality = 0.2, P < 0.0001) confirming that the tendency to demonstrate seasonal dynamics between the different retained studies depends largely on the degree of statistical or mathematical technical Sophistication of the study.