Excerpts

Both parametric and non-parametric statistical tests confirmed these findings were highly significant ( t -test and Mann-Whitney U , P < 0.0001), and the effect size was moderate, demonstrating genuine operational impact ( Table 2 ).

The heterogeneity test yielded a highly significant result ( Q = 1052, df = 20, P < 0.0001, τ2 (between-study) = 1417, τ2 (within-study) = 12029), with 89.46% of the total variance ascribed to within-study variation and 10.5% to between-study differences, indicating substantial biological and methodological variability among included studies.

The mean wheal size of S-DP was significantly higher than C-DP across all dilutions, which was highly significant with P value of <.0001 ( Table 2 , Figure 3 ).

This analysis showed a highly significant positive correlation between the two datasets for both the SLC transporters (r = 0.9157, P < 0.0001) and the ABC transporters (r = 0.8368, P < 0.0001) (Fig. 3 , Supplementary Tables S3 and S4 ), providing further confidence in our approach.

The effect of the genotype and pairwise-comparisons between the associated genotypic groups were highly significant ( p < 0.0001) (Fig. 4b ; Supplementary Table 4 and Supplementary Data 4 ).

The strongest predictor of adult alcohol problems was whether one felt drunk at first episode and this was highly significant in all analyses, including the multivariable model with the most rigorous adjustment for confounders (regression coefficient: 0.3848, p<0.0001).

The adjusted PR of CVD associated with age >50 years was 5.374 [95% CI: 4.820-5.992] times higher than those with age ≤50 years, and the effect was statistically highly significant ( P < 0.0001).

Differences in the fraction of the brain lobe area occupied by the NE and the CB are highly significant between mbt males and their female siblings ( P < 10 −4 ) and insignificant between mbt females and wild-type brains of either sex ( Fig. 1B ).

Simultaneously, the results from Table 2 reveal that the individual factors A and D exert a highly significant influence on the response value ( p < 0.0001), while factors B and C exhibit a significant impact ( p < 0.05).

Co-infection analysis showed a highly significant association with HIV (p<0.0001, OR=26.32, 95% CI: 20.22-34.28).

Notably, cadaverine, N-acetylcadaverine, choline, tryptophan, and glycine exhibited highly significant differences ( p < 0.0001).

The association between age and binocular vision anomalies was highly significant (X 2 =95.01, df=10, p=0.0001), as shown in Table 2 .

Log-rank test confirmed highly significant survival differences between infected controls and phage-treated groups ( P < 0.0001).

boulardii CW extract was highly significant in all groups, except the group with 2.5 mg/mL concentration ( P <0.0001).

As shown in the last column of Table 3 , the instrument is highly significant ( p-value<0 . 0001 ) and positively associated with the spending on the anti-ACA advertisements.

A paired t ‐test confirmed that this advantage was highly significant ( t (10) = 11.32, p < 0.0001, one‐sided; mean difference = 0.029, 95% CI [0.023, 0.035]; Cohen's d = 3.41), with the Wilcoxon signed‐rank test in full agreement ( W = 66, p = 0.0005).

4 D). Protein and mRNA expression ratios showed a highly significant but weak positive correlation (Pearson's r = 0.405, Spearman's r = 0.378, both P < 0.0001) based on 2456 mRNA–protein pairs (Fig. 4 E).

This difference was highly significant at 14 dpi ( S4A–S4B” Fig ; Kolmogorov- smirnov test, p<0.0001), but diminished over time, as the WT cells caught up at 28 and 42 dpi.

Stepwise regression with the equilibrium genetic correlation as the dependent variable and the parameters , , G ratio , P ratio , ν , N , and their interactions as independent variables produced a highly significant model ( F 15,885 = 556.9, P < 0.0001) that accounted for 90.4% of the variance in the equilibrium genetic correlations.

Therefore, the interaction effect of genotype and feeding regimen reached statistical significance for latency time (F(1, 25) = 45.90, p < 0.0001 and F(1, 25) = 10.47, p = 0.0034, respectively), whereas a near-significant trend was evident for the number of buried marbles (F(1, 22) = 33.06, p < 0.0001 and F(1, 22) = 3.943, p = 0.05970, respectively).

When the repeat number added to the expanded allele in each organ from multiple animals was averaged, the effect of the loss of one or both Mlh3 alleles was found to be highly significant for all organs ( Fig 1B ; p < 0.0001).

Among LAC patients with additional tissue section available for next-generation sequencing (NGS)-based analysis, 26/193 (13.5%) patients found positive for even low-rate EGFR-T790M mutated alleles at baseline were associated with a highly significant lower survival in comparison to those without (8.7 vs. 47.4 months, p < 0.0001).

Two-way mixed ANOVA showed a highly significant Time × Treatment interaction (F (4,95) = 39.77, P < 0.0001), along with significant main effects of Time (F (1,95) = 356.8, P < 0.0001) and Treatment (F (4,95) = 147.1, P < 0.0001).

156±29.6 pg/ml for T2DM and healthy controls, respectively), increase that is statistically highly significant (P<0.0001).

No significant correlation was found with Dukes' stage (P= 0.15), but a highly significant correlation was obtained with DNA index > 1.30 (P<0.0001) as well as 17p loss (P< 0.002). p53 content was also significantly different when it was compared to tumour site (P<0.03), with a considerably reduced incidence in the proximal colon (42.1% positive cases) compared to an average of 74.8% in the distal seg- ments. r- U- 0 30 60 FL2 b 0 30 60 FL2 C 0 30 60 FL2 Figure 4 p53/DNA FCM results for a tumour of the rectum (DNA index 1.15).