Barely Significant

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highly significantp = 0.00010.0× alphaqualifiedgold
The between subjects results of a repeated measures ANOVA comparing the left and right hemispheric GMV's from FS with gender and D_AEP and their interactions as factors was highly significant for the whole model (F = 11.04, df = 3,22, p = 0.0001) as well as for the interaction between gender and D_AEP (F = 16.41, df = 1,22, p = 0.0005).
highly significantP < 0.00010.0× alphaqualifiedgold
However, we noted a 20-fold increase in the frequency of H2AX −/− bouquet-stage nuclei ( H2AX −/− , 6%; wild-type, 0.4%; based on 2,567 mutant and 2,772 wild-type spermatogenic nuclei), with the differences being highly significant (P < 0.0001; χ 2 and Fisher test; Fig. 2 B).
H2AX regulates meiotic telomere clustering.
J Cell Biol · 2003 · PMC2173436
highly significantP < 0.00010.0× alphaqualifiedgold
These observations were quantitatively corroborated by fluorescence intensity analysis, which revealed a more than 3-fold increase in the FAM channel signal in chemoresistant U251 MG/TMZ cells compared to that in U251 cells, with highly significant statistical differences ( P < 0.0001, Fig. 5E ).
highly significantP < 0.00010.0× alphaqualifiedgold
The remaining absorbance after 3 hours (OD 620 , 3 h) was greater than 100% relative to the initial absorbance in 29 (58%) of ESBL isolates and in 11 (22%) of non-ESBL isolates, so these isolates were designated serum resistant and the difference was highly significant ( P < 0.0001).