Excerpts

Of the four rare variants, two were nonsynonymous to SLC5A10 and were highly significant (rs148178887, p = 1.13 × 10 −36 and rs61741107, p = 8.85 × 10 −56 ).

We found a highly significant replication (mean R 2 for expression = 0.071; p = 1.3 × 10 −36 ; mean R 2 for splicing = 0.047; p = 2.1 × 10 −29 ), with 50.2% genes and splicing having R 2 > 0.01 (Supplementary Figure 9 ).

We find a highly significant difference between these two means [t-test: t (478) = −13.618, p = 1.51×10 −36 ], indicating that, on average, observers are able to estimate admixture levels from photographs better than chance.

The differences in TIL scores between the 6 glioma entities were highly significant ( Figure 5b , p = 1.6e-36).

A highly significant overlap was found with ALI-grown healthy epithelial cells exposed to interleukin (IL) -13 ( GSE37693 ; p = 1.61E-36) and freshly isolated epithelial cells from severe asthmatic patients ( GSE63142 ; p = 1.24E-08) (Fig. 2m ).

The observed 1.8‐fold enrichment was highly significant (Fisher's exact test, P = 1.90 × 10 −36 ).

The correlation between mean catch-up saccades per second and microsaccades rate was moderate, with a Pearson correlation coefficient of r = 0.58, a 95% confidence interval of [0.51, 0.64], and a highly significant p-value ( p = 1.99e-36).

To test this possibility, we plotted final spindle length as a function of the area of the cell measured from DIC images, which is a proxy for cell volume because of the rotational symmetry of the embryo, across the RIAIL panel, and observed a highly significant correlation ( Figure 2D , p = 2.97E-36).

Although this genetic risk score shows a highly significant association in Caucasian ( P =3.94 × 10 −36 ), there is no evidence of association in the Chinese population ( P =0.21; Fig. 5 ).

The genomewide correlation using LDSC resulted in a very high genetic correlation between the male and female PD GWASes (rg = 0.877, SE = 0.0699) which was highly significant at a p = 4.24E‐36.

Coexpression of CD47 and IFT57 mRNAs Is Intrinsic to Cancer Cells A highly significant positive correlation was also observed between CD47 and IFT57 mRNA expression across the 1156 cell lines in the Cancer Cell Line Encyclopedia (CCLE) [ 26 ] ( p = 4.6 × 10 −36 , Table 1 , Figure 1 d).

The read accuracy improvement of using ORP over single reads, revealed as a gap between their respective error profiles, was most prominent at Q10 and diminished with higher Q-score filtering; the advantage at Q30 was small yet still highly significant (two-sample Kolmogorov-Smirnov test p = 5×10 -36 and 2×10 -11 for rabies and BCV control, respectively), as any reduction in error rate can be used to detect viral variants with greater sensitivity.

CHUP1 Candidate Gene for bgm-1 The GWAS analysis of CIAT’s 412 breeding lines detected a highly significant interval on Pv03: 2.43–2.54 Mbp with a peak SNP S03_2524224 [−log10( P -value) = 35.23] ( Table 3 and Supplementary Table 3A ).

The correlation of IVW analysis is highly significant (β = −0.16, P = 5.91 × 10 −36 ).

These contrasting strategies are highly significant ( P < <0.001, Welch’s t- test, t = 54.6, P = 6 × 10 −36 ; n = 18 for D-lactate, n = 20 for L-lactate) and likely alter competitive dynamics in lactate-limited systems.

Our analysis revealed a highly significant correlation between the 12-protein panel and the classical AD biomarkers (297_CSF: positive correlation: Aβ 42 , R = 0.31, P = 7.5e-0.8; Aβ 42/tau , R = 0.64, P = 6.6e-36; negative correlation: p-tau, R =-0.62, P = 7.5e-33; t-tau, R =-0.76, P = 2.4e-57; Fig. 3 A).

We observed a marked elevation of EP300 protein abundance in HCC tissues compared to adjacent normal liver tissues, with a highly significant difference ( p ≈ 7.60 × 10^−36, Fig. 1 D).

This enrichment is highly significant with a P < 7.98E-36 using the hypergeometric test.

The t-test shows that the difference between DRNF and HHpred is statistically highly significant (P-value = 8.2E-36), so is the difference between DRNF and CNFpred (P-value = 8.5E-15).

IPA analysis also identifies, in both brain areas, several highly significant upstream regulators; that is, the transcription factors, Irf3 (F/M: p < 8.5E-36, z = 5.2; Cb: p < 6.6E-17, z = 4.7); Irf7 (F/M: p < 1.1E-28, z = 4.6; Cb: p < 5.7E-15, z = 4.1); the interleukin Ifng (interferon gamma; F/M: p < 9.9E-33, z = 6.3; Cb: p < 1.5E-26, z = 7.1); and interferon alpha/beta receptors ( Ifnar1 and Ifnar2 ; F/M: p < 1.4E-44, z = 6.2; Cb: p < 1.5E-25, z = 6.2).

The overlap of the downregulated genes in strains overexpressing the D303A or D346A variants compared to those in the strain overexpressing wild-type RNase E was statistically highly significant ( P < 10 –35 and < 10 –46 , respectively, hypergeometric test).

Of the top 100 proteins highest in the s11 subtype, 58 were among the top 10% brain tissue-specific genes, a highly significant overlap ( p < 1E−35, one-sided Fisher’s exact test).

rs13038305 in relation to plasma cystatin C and creatinine based measures of GFR In the MDC-CC, each copy of the major allele of rs13038305 was associated with a highly significant (P<1 x 10 −35 ) approximately one third of a SD increase of plasma concentration of cystatin C both in model 1 and model 2.

The results showed pathways involved in repairing damaged nucleotides/DNA as highly significant in determining alkylating agent sensitivity: the Fanconi anemia pathway, ( p = 1.04 × 10 −35 ), homologous recombination (2.00 × 10 −24 ), nucleotide excision repair (2.77 × 10 −9 ), and non-homologous end-joining (1.04 × 10 −7 ) ( Figure 6 ). 3.

P values identified CodY as ontology term more likely to be significant among genes with higher transcript levels at 15 min ( P = 1.28*10 −35 ), 30 min ( P = 1.17*10 −45 ) and 18 h ( P = 0.0000802).