Excerpts

The largest data freeze to date ( https://www.covid19hg.org ) does not include rs4702 within its summary statistics; however, we note an excess of nominally significant genetic variants within the FURIN cis -region ( Table S1 ; binomial test p = 3.57 × 10 −31 ) comparing individuals hospitalized from COVID-19 with the general population ( Initiative, 2020 ).

Concordance of the direction of the effect of the largest variance component was also highly significant ( p = 5.71 × 10 −31 , Supplementary Table S3 ).

The hit SNP is in high LD with this common 2-base pair deletion (labelled as chr17:44102741:D in 1000 Genomes or as rs67759530 in dbSNP) within the probe ( r 2 = 0.91, minor allele frequency = 23%), giving rise to a highly significant association in the Illumina HT12 data set ( P -value = 8 × 10 − 31 ).

The correlation between the trial-by-trial change of phasic pupil dilation and that of absolute movement error for the group-averaged data was highly significant ( r = 0.64; P = 8.97 × 10 31 ; bootstrap 95% confidence interval: [0.43, 0.80]), suggesting that the phasic pupil dilation may reflect error size.

Vaccination also resulted in a highly significant improvement of average daily weight gain (+ 46 g/day; P = 9.55 × 10 -31 ) and carcase weight (+ 1.25 kg; P = 4.54 × 10 -05 ) as well as a shortened fattening period (-8 days; P = 2.01 × 10 -45 ). status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2008 Aug 18; Accepted 2009 Jan 7; Collection date 2009.

In areas where the absolute value of log2FC was larger than 2, highly significant genes (-log10( p -value) > 30) were primarily enriched, suggesting a high degree of consistency in differential expression patterns across various data sources.

Figure 2a shows that there was a highly significant difference between the two groups, with a mean variance explained by individual of 74 % for the strong-eQTL group, and 65 % for the weak-eQTL group (ANOVA, p < 10 −30 ).

Correlations between video tracker drifts and their search coil counterparts were moderate (average vertical ρ = 0.58 ± 0.09; average horizontal ρ = 0.51 ± .09) but highly significant (all p -values < 10 –30 ).

Suppression of PAPD4 also led to a highly significant reduction in miRNA expression, (t-test adjusted p value <1×10 −30 ), although the median relative miRNA expression value of 0.71 in siPAPD4 cells was of a smaller magnitude than observed from TUT1 suppression.

Logistic regression models predicting each treatment from diagnosis yielded highly significant associations (BH-adjusted p < 1 × 10 −30 ; Supplementary Data 5 ), indicating that diagnosis and treatment are not independently distributed.

(Of note, the EMN estimation was repeated across different p value thresholds [i.e., defined as the limit of the top 0.5% p values and top 0.3%], obtaining consistent results across all thresholds, with strong highly significant correlations with the original EMN values [all r ~ 0.84, p < 10 −30 ].) Next, taking the 7718 values as data, we used a novel contrastive trajectories inference (cTI) algorithm to aggregate the DNAm data by identifying the trajectories of individuals aligned/ordered with the severity of epigenetic alterations hypothetically associated with maternal neglect.

The purple regression line shows the highly significant correlation with log(income) that has been previously identified for the Gallup data ( P < 10 −30 ).

For example, in a recent meta-analysis of published studies, Li and colleagues (2011) reported that the association between rs1229984 and alcoholism is highly significant ( P < 10 −30 ) in Asian populations.

Notably, many of the highly significant GO terms are related to immune function and inflammation such as GO:0002376, immune system process [ P < 1e−30 both comparisons] and GO:0006954, inflammatory response [ P < 1e−30 both comparisons] (Fig. 6 A, Supplemental Table 1 ).

Functional enrichment analyses yielded major clusters for transcripts increased in ICD, including “collagen/extracellular matrix(ECM)”, “ECM-receptor interaction/PI3K-AKT signaling,” “inflammatory bowel disease”, and “Toll-like receptor signaling pathway.” Upstream regulator analysis revealed well-known inflammatory regulators interferon gamma (IFNγ), tumor necrosis factor (TNF), interleukin-1 beta (IL1β), and interferon alpha (IFNα) as highly significant (− log( p -value) > 30) in ICD animals relative to controls.

africanum found that SIT 181 was always detected as a highly significant emerging strain (p<10 −30 –10 −31 ), followed by several other strains ( Table 2 ).

Discussion Our GWAS across two cohorts of smallpox vaccine recipients, totaling just over 1,600 individuals, identified a highly significant (p < 1 x 10 −30 ) association signal from a region on chromosome 5 that was linked to significant inter-individual variations in IFNα response to in vitro stimulation with vaccinia virus.

The correlation between Π and δ is extremely significant, with Spearman's correlation R = 0.94, z -score 8.4, corresponding to p < 10 −30 (probability for fortuitous generation of such correlated data, under the hypothesis of null correlations).

Thus, we used HOMER analysis for known motifs, revealing highly significant consensus motifs such as NRF1 ( P = 10 −30 ) and ZBTB33 ( P = 10 −24 ) ( Fig S6A ).

The negative association between the changes at ZGA and upon Snrpb/d2 overexpression is highly significant ( P = 1.1 × 10 −30 , binomial test), suggesting that higher Snrpb/d2 levels before ZGA maintain alternative exon patterns in a more pre-ZGA state, a trend that was also observed for all exons together (fig.

For example, Pfam domains exhibit a highly significant, negative correlation between domain promiscuity (see Methods ) and sequence identity (ρ = −0.21, p = 2.08 e −30 , Spearman test).

Functional analysis also implicated olfactory activity as a highly significant ( P = 2.310 × 10 –30 ) function of the top 100 most saturated downregulated genes.

Across cell types and haplotypes, we found a positive and highly significant correlation (Pearson correlation; cell type: p = 2.36 × 10 −30 , haplotype p = 6.76 × 10 −4 , Fig. 7d ) between gene expression fold change and chromatin loop fold change, and between H3K27ac fold change and loop fold change (Pearson correlation; cell type: p = 6.6 × 10 −211 ; haplotype: p = 4.63 × 10 −5 , Fig. 7e ).

In contrast to the above mutation hotspots, phosphosites in TP53 termini appear as highly significant mutation deserts (three pSNVs observed, 67±8 expected, P =2.8 × 10 −30 from ActiveDriver).

Specifically, M186 was enriched (Adj p = 3.8e−03) for class-switched memory B cells ( BANK1 , IGHA2 , PAX5 , and SPIB ), whereas M181 showed highly significant enrichment (Adj p = 3.6e−30) for plasma cells ( FCRLA , HERPUD 1, JCHAIN , MZB1 , TNFRSF17 , and multiple V region genes).