Excerpts

Both the DLCV error as well as the error on the validation set show a highly significant correlation with the number of artificial datasets that is pooled, Pearson correlation of -0.91 ( p = 1.1 e - 24) and -0.95 ( p = 1.4 e - 31), respectively.

Compared with the expected overlap (based on a random distribution of mutations and polymorphisms), the overlap between polymorphisms in all of our MA lines and populations with those of natural variants is highly significant (Fisher’s exact test: SNV, p = 2 × 10 –24 ; indel, p = 1 × 10 –12 ; Fig. 8 ).

Intriguingly, DAVID analysis of the 82 LG-only DEPs revealed a highly significant over-representation of extracellular exosomes (53 proteins, p = 2E − 24) (Additional file 2 : Table S7), suggesting the possibility of differential exosome biogenesis and/or shedding in the two groups.

A test of homogeneity for the core matrisome proteins revealed a highly significant difference between native and dECM livers (χ 2 = 109.91, P = 2.76 × 10 −24 ), indicating that the relative abundance of core ECM components was markedly altered following decellularization.

disease controls were highly significant (P = 3×10 −24 ).

The observed correlation had a very high positive degree and was highly significant (R = 0.95, p-value = 3 × 10 -24 , see also the regression plot in Supplementary Fig.

briggsae AF16 ↔ HK104), Ts/Tv had a narrower range from 1.01 to 1.42 though the variation was highly significant ( P = 3.3 × 10 − 24 , X 2 test), primarily due to the unusually low ratio in the N2 ↔ CB4856 SNPs.

In one of these patients (Control 1), STRetch identified the highly significant expansion of SCA8 (noted above), a known but rare disease locus in ATXN8 with an outlier z-score of 11.11 ( p = 3.55e-24) and an estimated allele size of 54.4×.

Seventy three of the core response genes to MAB were also identified as part of the core response to MTB (Additional file 6 : Table S3), representing a highly significant overlap ( P < 5.482e-24, hypergeometric test) and suggesting a conserved role for type-I IFN responses across diverse mycobacterial species.

A chi‐squared test between treatment groups and gel categorization scores found a highly significant association between these two categorical variables (chi‐square test, p ‐value = 6.53 × 10 −24 , Figure 6 ).

While rs2647044 ( P = 3.85×10 −20 ) was still highly significant, rs9357152 ( P = 7.28×10 −24 ) became the most significantly associated SNP when the effects from the known HLA high-risk genotypes were accounted for in the logistic regression model.

Ingenuity pathway analysis identified highly significant overrepresentation of several pathways, including oxidative phosphorylation (OXPHOS; p = 8.1 × 10 −24 ) and mTOR signaling (p = 8.5 × 10 −10 ) ( Figure 5 C).

For example, when distinguishing individuals with MCI from those with CN, CR-Proxy showed a highly significant difference ( p = 8.14 × 10 − 24 , Cohen’s d = 0.68 ), compared to Brain-PAD ( p = 6.93 × 10 − 4 , d = − 0.25 ).

This difference was highly significant ( p = 8.23 × 10 −24 ).

Together they form a highly significant reaction set (P < 10 -23 for each of the three possible reaction pairs), whose congruence in genomic association is nearly perfect.

For Abpa paralogues (Figure 6A ), we were unable to detect strong evidence of positive selection: M1/M2 test did not show evidence of selection (P > 0.25), while the M7/M8 test was highly significant (P < 10 -23 ).

In the ser2 Δ background strains, one‐way ANOVA identified highly significant differences among plasmid constructs ( P < 10 −23 ), and Tukey's HSD post hoc test resolved distinct complementation groups.

This represents a highly significant (Chi-square test, P < 10E-24) deviation from expectation (108 deletions, 106 insertions, based on their proportion in the set of 5167 SVs that could be aligned to both apes).

Consistent with Lirnet's predictions, we observed a modest but highly significant down-regulation (KS p-value<10 −23 ) of the Puf3 module in the RM mkt1Δ strain ( Figure 8C ).

This difference was highly significant, reflecting a strong main effect of stimulus type on mean RT ( F (1,108) = 167.01, p = 1e‐23), and remained significant within both HCs ( t (36) = 9.84, p = 9e‐12) and PwMS ( t (72) = 10.05, p = 2e‐15).

Summarizing the results to this point, the genome-wide association study revealed a highly significant association in the vicinity of Lgi2 , an extremely strong association (p = 1.05×10 −23 ) with the protein-truncating c.1552A>T (p.K518X) sequence change in the gene, and no significant association with any other locus.

One-way MANOVA showed that multivariate differentiation among the three major groups was highly significant (Wilk’s lambda = 0.4237, df1 = 56, df2 = 520, F = 4.98, p = 1.108E-23).

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

Calculating the probability of observing this increase by chance according to the hypergeometric distribution indicates that this increase is highly significant ( P = 1.12E–23).

Both variants were associated with expression levels of NBR2, CTD-3199 J23.6 and LINC00854 genes with a highly significant eQTL evidence for NBR2, a BRCA1 neighbor gene ( p = 1.2 × 10 − 23 and p = 2.1 × 10 − 25 for rs9911630 and rs799916, respectively) (Additional file 2 : Figure S1).