Excerpts

Both the DLCV error as well as the error on the validation set show a highly significant correlation with the number of artificial datasets that is pooled, Pearson correlation of -0.91 ( p = 1.1 e - 24) and -0.95 ( p = 1.4 e - 31), respectively.

Compared with the expected overlap (based on a random distribution of mutations and polymorphisms), the overlap between polymorphisms in all of our MA lines and populations with those of natural variants is highly significant (Fisher’s exact test: SNV, p = 2 × 10 –24 ; indel, p = 1 × 10 –12 ; Fig. 8 ).

Intriguingly, DAVID analysis of the 82 LG-only DEPs revealed a highly significant over-representation of extracellular exosomes (53 proteins, p = 2E − 24) (Additional file 2 : Table S7), suggesting the possibility of differential exosome biogenesis and/or shedding in the two groups.

A test of homogeneity for the core matrisome proteins revealed a highly significant difference between native and dECM livers (χ 2 = 109.91, P = 2.76 × 10 −24 ), indicating that the relative abundance of core ECM components was markedly altered following decellularization.

disease controls were highly significant (P = 3×10 −24 ).

The observed correlation had a very high positive degree and was highly significant (R = 0.95, p-value = 3 × 10 -24 , see also the regression plot in Supplementary Fig.

briggsae AF16 ↔ HK104), Ts/Tv had a narrower range from 1.01 to 1.42 though the variation was highly significant ( P = 3.3 × 10 − 24 , X 2 test), primarily due to the unusually low ratio in the N2 ↔ CB4856 SNPs.

In one of these patients (Control 1), STRetch identified the highly significant expansion of SCA8 (noted above), a known but rare disease locus in ATXN8 with an outlier z-score of 11.11 ( p = 3.55e-24) and an estimated allele size of 54.4×.

Seventy three of the core response genes to MAB were also identified as part of the core response to MTB (Additional file 6 : Table S3), representing a highly significant overlap ( P < 5.482e-24, hypergeometric test) and suggesting a conserved role for type-I IFN responses across diverse mycobacterial species.

A chi‐squared test between treatment groups and gel categorization scores found a highly significant association between these two categorical variables (chi‐square test, p ‐value = 6.53 × 10 −24 , Figure 6 ).

While rs2647044 ( P = 3.85×10 −20 ) was still highly significant, rs9357152 ( P = 7.28×10 −24 ) became the most significantly associated SNP when the effects from the known HLA high-risk genotypes were accounted for in the logistic regression model.

Ingenuity pathway analysis identified highly significant overrepresentation of several pathways, including oxidative phosphorylation (OXPHOS; p = 8.1 × 10 −24 ) and mTOR signaling (p = 8.5 × 10 −10 ) ( Figure 5 C).

For example, when distinguishing individuals with MCI from those with CN, CR-Proxy showed a highly significant difference ( p = 8.14 × 10 − 24 , Cohen’s d = 0.68 ), compared to Brain-PAD ( p = 6.93 × 10 − 4 , d = − 0.25 ).

This difference was highly significant ( p = 8.23 × 10 −24 ).

This difference was highly significant, reflecting a strong main effect of stimulus type on mean RT ( F (1,108) = 167.01, p = 1e‐23), and remained significant within both HCs ( t (36) = 9.84, p = 9e‐12) and PwMS ( t (72) = 10.05, p = 2e‐15).

For Abpa paralogues (Figure 6A ), we were unable to detect strong evidence of positive selection: M1/M2 test did not show evidence of selection (P > 0.25), while the M7/M8 test was highly significant (P < 10 -23 ).

Consistent with Lirnet's predictions, we observed a modest but highly significant down-regulation (KS p-value<10 −23 ) of the Puf3 module in the RM mkt1Δ strain ( Figure 8C ).

Together they form a highly significant reaction set (P < 10 -23 for each of the three possible reaction pairs), whose congruence in genomic association is nearly perfect.

This represents a highly significant (Chi-square test, P < 10E-24) deviation from expectation (108 deletions, 106 insertions, based on their proportion in the set of 5167 SVs that could be aligned to both apes).

In the ser2 Δ background strains, one‐way ANOVA identified highly significant differences among plasmid constructs ( P < 10 −23 ), and Tukey's HSD post hoc test resolved distinct complementation groups.

Summarizing the results to this point, the genome-wide association study revealed a highly significant association in the vicinity of Lgi2 , an extremely strong association (p = 1.05×10 −23 ) with the protein-truncating c.1552A>T (p.K518X) sequence change in the gene, and no significant association with any other locus.

One-way MANOVA showed that multivariate differentiation among the three major groups was highly significant (Wilk’s lambda = 0.4237, df1 = 56, df2 = 520, F = 4.98, p = 1.108E-23).

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

Calculating the probability of observing this increase by chance according to the hypergeometric distribution indicates that this increase is highly significant ( P = 1.12E–23).

Both variants were associated with expression levels of NBR2, CTD-3199 J23.6 and LINC00854 genes with a highly significant eQTL evidence for NBR2, a BRCA1 neighbor gene ( p = 1.2 × 10 − 23 and p = 2.1 × 10 − 25 for rs9911630 and rs799916, respectively) (Additional file 2 : Figure S1).