Excerpts

For our list of 64 miRs, 18 enrichment pathways are highly significant ( p < 1E-16).

STRING analysis revealed highly significant connectivity between almost all input genes (enrichment p -value < 1 × 10 −16 ), suggesting that TCF19 may be regulating one cluster of interconnected genes ( Figure 2 B).

Hub genes from PPI network Key targets were imported into the STRING database to construct a PPI network comprising 236 nodes and 3,711 edges, with highly significant enrichment ( p < 1.0 × 10 −16 ).

Follow up genotyping of 70 rare and low-frequency protein-altering variants (MAF ~ .001-.05) in nine independent case-control series (16054 CD patients, 12153 UC patients, 17575 healthy controls) identifies four additional independent risk factors in NOD2 , two additional protective variants in IL23R , a highly significant association to a novel, protective splice variant in CARD9 ( p < 1e-16, OR ~ 0.29), as well as additional associations to coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19 .

In comparison, full-field static flashes were represented by waveforms that were 147 ± 4% and 115 ± 2% of the full-field motion responses in the two populations; this difference in the ratio between responses to stationary flashes and full-field motion was highly significant ( p < 10 −16 , Fig. 2e ).

These results show that all four topological measures provide highly significant ( p -value < 1e-16) enrichment in pathogen targets, with betweenness and clustering coefficient displaying highest enrichment, thereby demonstrating the added value of incorporating PPI data into inferred networks for a generalizable approach to identify target regulatory nodes within networks.

The analysis revealed a highly significant interaction network among the differentially abundant proteins ( p < 1.0 -16 ), indicating that down-regulation of these protein interactions may play a crucial role in modulating intracellular biological processes in pigs fed a BET diet. 3.2.

Notably, only proteins associated with our list of cKO- Eed -MADM–specific DEGs, but not sparse Eed -MADM–specific DEGs, formed a highly significant and densely connected network (PPI enrichment P value < 1 × 10 −16 ) (fig.

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: philippk08@gmail.com.

The correlation between the distance of GO groups in the 0.001 cutoff co-evolution network (that is, their evolutionary distance) and their distance in the corresponding GO ontology network (that is, their functional distance) is highly significant: 0.38 for cellular component, 0.16 for biological process and 0.43 for molecular function (all three with P -values <10 -16 ; a similar trend is observed using the 0.01 cutoff network).

The network showed highly significant PPI enrichment (p < 1.0 × 10 −16 ), with an average node degree of 3.52 and a local clustering coefficient of 0.497, supporting the presence of a non-random and moderately clustered interaction structure.

It further confirmed that the association of clock PRRs with flowering control genes was not random and connected with a highly significant value of p < 1 × 10 −16 .

The constructed PPIN comprised 44 molecular nodes interconnected by 296 edges, demonstrating highly significant interaction enrichment ( p = 1.0e-16).

Across all 10‐kb windows in the genome, there was a weak but highly significant correlation in the distribution of Tajima's D values in the two clusters (Figure 4 b; Spearman's ρ = 0.25; p < 10 −16 ).

This highly significant directionality ( P < 10 -16 ) is not expected by models of statistical positioning, but suggests instead that Isw1-dependent shifts reflect its function during elongation [ 15 ].

The network demonstrated highly significant connectivity (PPI enrichment p -value < 1 × 10 −16 ), as 201 interactions were observed compared to the 27 edges expected by chance, supporting functional relationships among the proteins rather than random connectivity.

As illustrated in Figure 3 , there was a highly significant correlation between the genetic and transcriptome covariances for this set of genes ( r = 0.035, P = 1.0 × 10 −16 ; Figure 3 ).

There is a highly significant correlation between F ST and A ancestry difference between the lowland and highland samples (Spearman's ρ = 0.26, P < 10 −16 ).

Cruise-specific calibrations of shipboard fluorometers, nephelometer/optical backscatter, and oxygen sensors yielded highly significant ( P <10 −16 ) linear relationships between all discrete and calculated concentrations of chlorophyll- a , SPM and DO ( Fig. 3 ).

The network showed strong biological relevance with highly significant enrichment ( p -value < 1.0e-16).

STRING analysis reveals a highly significant clustering ( p = 1 × 10 −16 ) of over 90% of the proteins identified ( Figure 7 ), with the existence of sub-clusters related to ER protein quality control, mitochondria membrane protein translocation, nuclear import, and stress granules.

The enrichment was highly significant (PPI enrichment p < 1.0e− 16 ), demonstrating that the observed interactions were unlikely to occur by chance.

Comparing gametic disequilibrium between high-sugar and control populations for SNPs showing positive selection unique to the high-sugar regime revealed a small but highly significant negative correlation (r = −0.06, P < 10 −16 ).

This yielded a PPI with 235 edges with an extremely significant enrichment p -value < 1.0e−16 ( Fig. 10 ).

Protein-protein interaction (PPI) analysis using STRING ( Szklarczyk et al., 2019 ) revealed that the hub proteins, including MSN, EZR, C1qa, a key component of the complement cascade, and GFAP, belong to a PPI network with highly significant interactions (p-value = 1.0e-16) ( Figure 4 B).