“a clear trend”

28 A clear trend in the SAR was the expected increase in potency when comparing compounds containing an aldehyde warhead to the structurally analogous nitrile.

The dihedral angle α of the four compounds reported here follows a clear trend.

Correlating the calculated D confocal values with p K a shows a clear trend, where diffusion is strongly slowed down at higher p K a values ( Figure 9C ).

As illustrated in Figure 2 , the age-normalized Vd increased with advancing age, indicating a clear trend across different age groups. 3.4 Model validation The robustness and stability of the final pharmacokinetic model were evaluated using both bootstrapping ( Table 2 ) and prediction-corrected visual predictive checks ( Figure 3 ).

On the contrary, the average changes in 6MWT do not show a clear trend, with a significant reduction in the endurance improvement compared to T0 observed at T2, T5 and T8 which does not allow a clear interpretation of the results.

However, in the presence of vitamin D, a clear trend towards a smaller increase in inulin-FITC diffusion was detected, suggesting the protective effect of vitamin D on the proximal tubule epithelial barrier integrity.

A clear trend was noted between Area 3 (between the production lines) and Area 4 (dispersion of bottles) with distinguished higher diversity and representability of the same species in both seasons.

A clear trend of high average glc concentration was observed in class A, B, and C after 6 months’ storage at 5.5°C storage ( S3 Table ).

Even though there is a clear trend in the direction of open science, a lot of companies still prefer to protect their investments by limiting the access to source code or labeled data, both being obtained with considerable resources.

The analysis indicates a clear trend of intensifying surface temperatures in conjunction with ongoing urban expansion.

Behavior assessment The behavioral responses of mahseer to different temperature and CO 2 conditions indicate a clear trend in physiological adaptability and stress tolerance (Table 3 ).

Although no significant difference was identified on the levels of the 16 selected autoAbs between SLE-LN + and SLE-LN − , two of the IgG autoAbs (anti-HMGB1 and anti-APEX1) showed a clear trend of increased expression in SLE-LN + compared with SLE-LN − as shown in Figure 5 G and H.

There is a clear trend for those plants with reduced biomass with reduced NO 3 − availability also having lower net N uptake.

For example, a cross‐sectional, retrospective study of 1200 patients with gout demonstrated that treatment with colchicine, a general anti‐inflammatory agent, resulted in a significantly lower prevalence of MI and a clear trend towards reduced all‐cause mortality compared with patients who did not take colchicine. 2 Additionally, a randomized clinical trial evaluated the effects of canakinumab, an anti‐IL‐1β monoclonal antibody, on the occurrence and degree of gout symptoms.

These findings were supported by a clear trend to an infiltrative growth and a higher probability of recurrence in HCC cases when overexpressing FGF9 (Figure 3C ) as well as by reports on models of various cancer entities. 19 , 21 , 24 , 25 To conclude, FGF9 may be an important driver of the aggressive phenotype by enhancing growth and invasiveness of HCC cells.

The absence of a clear trend indicates that, even when restricting the analysis to the period of maximum plant activity (June–August, daytime), the energy imbalance does not scale with photosynthetic uptake.

We examined whether antibody levels trended higher based on the number of days between symptom onset and sample collection but were unable to detect a clear trend, even after stratifying by number of vaccine doses received ( Appendix Figure 4), potentially because 50% of NAAT-positive case-patients had samples collected within 3 days of symptom onset and 90% within 6 days ( Appendix Table 1).

A meaningful statistical analysis was hindered by the low sample size, but the values did not seem to suggest a clear trend in the differences between the two limbs within the groups.

The OPLS-DA score revealed that the NC, disease, and DS groups exhibited a clear trend of separation (Fig. 9 a,b).

Currently, there is a clear trend toward developing on–off type devices for quick and easy screening of diseases focused on point-of-care in primary care centers or even domestic use.

The success of substructure determination, as evaluated by a plot of CC all versus CC weak from SHELXD , showed a clear trend of larger CC all /CC weak values for data sets with higher 〈 I /σ( I )〉 overall , CC anom overall and CC 1/2 overall values and lower R meas overall values (Fig. 3 ▸ ).

The variability in summer biomass, which lacked a clear trend, was only explained by the BSI.

Although we have not found a statistically significant excess of ASD individuals with disrupting variants in genes from M Neu 1-turquoise and M Neu 18-purple compared with controls, we did observe a clear trend toward this enrichment in M Neu 1-turquoise.

The changes in cholesterol lipids were cell type-specific, as they increased in Huh7 and SNU449 cells but did not present a clear trend in HepG2.

Looking at the prevalence of HAEC over time by dividing the included patients into four groups showed a clear trend of an increasing prevalence of postoperative HAEC, being lowest (13.1%) in group I (1979–1989) and highest (17.3%) in group IV (2010–2020).