Perhaps surprisingly, although there was a mild trend of lower levels of physical activity with rising weight status, more evident in the larger 2015 sample, these differences were comparatively mild compared to what might be expected if weight status and physical activity levels were strongly associated.
We observed a mild trend toward inhibition of adipogenic differentiation at the highest dose of EMD on human MSCs.
In this proof-of-concept study, a mild trend for reduced tumor volumes was observed when AAV vectors expressing anti-PD-1 scFv were combined with chemotherapy [ 189 ].
Moreover, these two miRNAs were selected, and both demonstrated increased expression within VHL-associated ccRCC tumors, but no statistically significant increases in expression were observed in the VHL urinary exosomes, although a mild trend was observed with miR-210-5p ( Supplementary Figures S3 and S5 ). 4.
A low dose (4 mg/kg) of WU8 showed a mild trend towards improved survival and less GvHD compared to the vehicle control ( Figure S1A,B ), although not as much as the high dose (20 mg/kg) of the drug ( Figure 5 A,B).
However, a mild trend was possibly observed in the increase of aggregate formation of the keratin network in comparison with the keratinocytes of the healthy donor (Staining against KRT14, Figure 3 ).
In contrast, there was even a mild trend of a location repetition cost occurring only in the shortest RSIs in error rates.
This pathology is associated with a mild trend toward depression in PARIS Tg mice, as indicated by the tail suspension immobility assay (Supplementary Fig. 4E).
Although the CF Group presented a mild trend to PFT recovery, there was no statistically significant difference between the situations ( Graph 1 ).
We found a mild trend toward increased heat production in the brown but not SubQ fat of male Ad- C3aR1 –/– mice compared with controls ( Supplemental Figure 3 , L and M).
In the developing mouse oocyte, depletion of the nuclear protein YTHDC1, which recognizes the RNA modification N 6 -methyladenosine (m6A), affected alternative splicing of 1966 genes and alternative 3’UTR processing of 864 genes, with a mild trend towards 3’UTR lengthening.
There was a mild trend toward a smaller decrease in percentage of predicted FVC in the NBP group than in the placebo group.
Plants with mis‐expressed miR390 (OXMIR390, Figure 1 e) had overall similar response to wild type, albeit with a mild trend toward increased primary root length in low (0.1–1 nM) IAA concentration.
In a small longitudinal study of four individuals with SCA3, five out of eight eyes evaluated showed a mild trend to RNFL thinning and the progression rate per year was calculated [ 49 ].
Although FAO dependency did not differ significantly across genotypes or treatments, a mild trend toward increased FAO reliance was observed in TNF-treated SNCA 3x ENLs under CSB6, potentially reflecting partial restoration of metabolic flexibility 74 .
Earlier studies also reported possible negative outcome after DBS for semantic and phonematic verbal fluency and a mild trend for a deterioration of verbal memory (Foki et al. 2017 , Foki et al. 2018 , Harati et al. 2013 ).
There was no significant difference in 24-h urinary sodium excretion, even if a mild trend toward a reduced sodium excretion was observed in young SHR; fractional excretion of sodium (FENa) was not changed.
We agree that this is a very interesting question, and we have now performed various additional studies to explore the role of nAchR signaling in ISC to EE differentiation: – To confirm our nAchR α2 MARCM data, we utilized the esgF/O strategy (Jiang et al., 2009) to knock down the expression of other subunits in clones via RNAi and observed a mild trend towards fewer EEs in α2 and α4 knockdowns (Figure 2 —figure supplement 2F).
When HGSOC were stratified to stage a mild trend of augmented RANK expression, an increasing stage was observed, but no significant differences were detected ( Figure 2 C). 2.1.2.
TGF-β showed a mild trend of increased expression at early time points whereas BMP-2 rose steadily throughout the investigated 8 weeks of healing, thus paralleling the observed increase in bone formation.
While there was no correlation between the curves during internal rotation, there was a mild trend during external rotation.
But the collection dates of BA.1.* exhibited a mild trend of late appearance and early disappearance ( Fig. 6A , upper panel).
Using a difference plot, a mild trend of differences was proportional to the measurement's magnitude.
Notably, while this group exhibited a mild trend toward reduced inflammation, the effect did not reach statistical significance.
And although a mild trend towards improvement in some dysphagia domains was evident, we found neither a statistically significant nor clinical meaningful impact.