In our larger mild dementia cohort, we did not detect a benefit of tDCS on K-MMSE–defined global cognition, but we did observe a small, statistically significant advantage in confrontation naming (K-BNT) favoring active tDCS and a numerical trend toward greater change on the RCFT in the active arm.
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“a numerical trend”
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21 , 40 In our study, EFS analysis stratified by pathological response showed a numerical trend toward better outcomes in MPR patients (median EFS 18·5 months) versus non-MPR (16·1 months), though the difference was not statistically significant, likely due to the modest sample size and short follow-up.
Both PPR and CD-TLR rates showed no significant differences among the 3 modalities (P = 0.23 for PPR, P = 0.85 for CD-TLR rate), although there was a numerical trend favoring DCB and stenting over POBA alone.
Even though it was not significant, the data indicate a numerical trend toward lower EQ-5D scores as the waiting times become longer.
These results suggest that while there is a numerical trend toward higher inflammatory burden at advanced stages, the differences were not statistically significant in this cohort.
The CD increased at the 0.25% DMP level ( p = 0.003), following a quadratic pattern, whereas the VH:CD ratio had only a numerical trend without statistical significance.
Notably, only the CC-0 showed a similar trend with the non-NACT group regarding overall survival, while the other subgroups exhibited a numerical trend without reaching statistical significance ( Figure 3 B).
Interpreting the mortality trend and key secondary outcomes A notable observation was a numerical trend favoring NMV-r for all-cause mortality reduction (adjusted hazard ratio [aHR] = 0.502).
First, as noted, a numerical trend toward higher values was even shown in the treated subgroup.
In CAPTAIN prespecified analyses [ 27 ], there was a numerical trend for a greater reduction in moderate/severe attacks among ex-smokers versus patients without smoking history after adding UMEC to FF/VI, although, as with other studies, the number of ex-smokers was low versus the other subgroups, and smoking history was limited (i.e., < 10 pack years).
Although there was a numerical trend in the predicted direction, which did not differ substantially between learning conditions (Fig. 4b ; Supplementary Fig. 5 ), we found no direct effect of signed image RPEs on memory ( ps ≥ 0.19; α corrected = 0.0125; Supplementary Table 12 ).
Although a numerical trend in BHB was observed, its lack of statistical significance and inconsistency with NEFA responses suggest that it does not represent a biologically relevant treatment effect.
Despite a numerical trend towards more students starting with SARI, suggesting a possible primacy effect, the platform order did not significantly influence the students’ preference.
A numerical trend indicated that pentoxifylline at a concentration of 22.0 mg/mL might exhibit greater efficacy; however, no statistically significant differences were observed among the various PTX doses tested.
When compared to other intervention schemes, anlotinib showed a numerical trend toward a lower risk of hypertension; however, these pairwise comparisons did not reach statistical significance ( P > 0.05).
While a numerical trend suggested better survival with daily amphotericin compared to alternate-day dosing, the difference was not statistically significant in this cohort; conversely, statistically significant associations between treatment schedule and disability were observed, possibly reflecting complex interactions among dosing, cumulative exposure, supportive care and selection bias (sicker patients may have received alternate dosing) ( 5 , 8 , 9 ).
In patients who underwent serial PET-CTs obtained before and during AKI, longitudinal analyses showed a numerical trend toward decreasing kidney SUVs in those with AKI from other causes and increasing kidney SUV in those with ICI-AIN, but these changes did not reach statistical significance.
In the IPC group, we found no significant differences concerning early- or late-onset of pleural infection, though with a numerical trend towards IPC removal in the late-onset group, see Table 3 .
Western blot analysis Densitometric analysis of the normalized PD-L1 protein levels revealed a numerical trend of increased expression in Grade-II tumors as opposed to Grade-I.
At 3 mm, a numerical trend toward higher values was observed in the SIM group (113.93 ± 85.81 vs. 46.47 ± 139.40), although this did not reach statistical significance ( p = 0.0825).
In the present correlative study from an investigator-initiated clinical trial, we report an enrichment in AR expression in HER2-low versus HER2-0 mTNBC, with a numerical trend in better prognosis observed among patients having both HER2-low and AR positivity.
At week 12, a numerical trend was noted in favour of BTFC eye gel over BTFC eye drops for the investigators (96.0% and 93.2%, respectively) and patients (95.3% and 91.3%, respectively).
In our cohort, this score showed a numerical trend toward survival stratification; however, differences in OS and disease control rate (DCR) did not reach statistical significance.
Our data, based on a smaller cohort with a median follow-up of 3.5 years, showed for patients experiencing a pCR a numerical trend towards worse 3-year RFS in TNBC, cT3-4 or cN+ disease, though differences were not statistically significant.
undergoing EVT (n=98) showed a numerical trend toward benefit (mRS responder: aOR 1.75) that was not statistically significant (95% CI 0.70–4.38).