However, the highest tertile (T3) of HbA1c was significantly associated with increased odds of HF in Model 1 ( P = 0.034) and Model 3 ( P = 0.028), with a significant trend observed in these two models ( P < 0.033).
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Subgroup analysis (tracer type, molecular subtype) was corrected using Bonferroni, and the corrected P -value threshold was 0.05/2 = 0.025: The original P = 0.037 in the tracer group → adjusted P = 0.074 (with a significant trend), and the original P = 0.033 in the molecular subtype → adjusted P = 0.066 (the differential trend still exists).
There was a significant trend towards more severe pruritus among poor responders compared with good responders ( p = 0.033), with a higher proportion of poor responders reporting moderate to severe symptoms.
Overall survival differed significantly by tumor type (p = 0.0395), with a significant trend across groups (p = 0.0340).
Separate trend analyses showed a significant trend in the non-obese group (χ 2 1 =4.520, P=.034) and no significance in the obese (χ 2 1 =0.679, P=.410).
When ANC maximum was measured, there was a significant trend ( P = 0.034) for the maximum ANC level achieved in stage II during cycle 1.
PFS analysis by quartiles of PLCγ1 expression [Q1 (0%–25%), Q2 (25%–50%), Q3 (50%–75%), and Q4 (75%–100%)] showed a significant trend that higher-expression patients progress faster under cetuximab therapy (log-rank test for trend, * P = 0.0340), with a clear distinction between Q1–2 versus Q3–4 patients (Supplementary Fig.
The multivariant adjusted model in NHANES found a significant trend ( P = 0.034) in increased risk for developing breast cancer across the four quartiles of urinary cadmium ( 52 ).
As demonstrated by linear regression model in Table 4 we observed a significant trend that survivors with CCI ≥ 1 ( β = 5.2, p = 0.034), tumor sits at nasopharynx ( β =-9.1, p = 0.034), or treated by 2DRT ( β =-12.2, p < 0.01) had a higher probability to report a high level of xerostomia.
The OR for the highest vs the lowest quintile of GI was 2.1 (95% CI: 1.2–3.6), with a significant trend in risk ( P =0.034).
When investigating the interaction between allocation and time, only actigraphy-measured sleep efficiency showed a significant trend over time ( p =.034).
At day 3 a significant trend of increased expression was observed for COL2A1 ( p = 0.034) and COL10A1 ( p = 0.012) with wildtype GDF5, and for COL2A1 ( p = 0.0068), MMP1 ( p = 0.037) and COL10A1 ( p = 0.027) with GDF5 variant.
Also, there was a significant trend towards less advanced nodal disease in the neoadjuvant group than in the adjuvant group ( P = 0.034) ( Table 3 ). 3.5.
Using water Mn concentrations as a continuous variable, the adjusted OR was 0.75 (95% CI 0.58–0.98, model I) per 1 mg/L (1,000 μg/L) increase in Mn concentration, with a significant trend ( P =0.034).
A significant trend towards decreased survival in patients with alcohol history compared to the patients without alcohol history, 42.3% vs. 76.9% (p=0.034), and a decreased survival rates in p16 negative patients compared to p16 positive patients, 43% vs. 69.7% (p=0.034) was noticed.
A significant trend towards better local control in hypoFx patients could be observed (overall LC 58.2% for nFx vs 90.5% for hypoFx, HR = 0.15, 95%CI: 0.02-0.86, p = 0.034) and high-dose PTV volume > 60 cm3 was a significant risk factor for locoregional progression (Figure 1). 11 patients (28.9%) developed ≥ G3 serious late complications, mostly soft tissue necrosis and infections which eventually improved in 6 of them.
For TTP as well as OS, there was a significant trend for increased survival in relation to increased expression of MHC II by the tumour ( P =0.034 and 0.043, respectively; log rank test for trend).
A significant trend indicating increased Nef-mediated SERINC5 downregulation function correlated with higher viral load was observed in subtype B viruses ( r = 0.6685 and P = 0.0346, Fig. 2 e).
There was a significant trend of TBUT improvement over the 12 weeks ( P =0.035) with no significant difference between treatment groups ( P =0.88).
When relative declines in serum CA125 levels were cross-tabulated with surgical outcome, a significant trend towards greater declines in those with a better surgical outcome was found (p=0.035) ( Fig. 2 ). 2.
When analyzed as a categorical variable, the multivariable- AOR from the lowest to highest quintiles of percentage energy from carbohydrate were 1 (reference), 1.062 (95% CI: 0.892–1.264), 1.263 (95% CI: 1.031–1.546), and 1.411 (95% CI: 1.083–1.839), with a significant trend ( P = 0.035).
Moreover, a significant trend towards increased in-hospital mortality was found in propensity score-adjusted regression in the unmatched population (odds ratio 3.12, p = 0.035), but this result was not significant in the matched cohort ( p = 0.095). 4.
Regarding the parameters related to kidney function, patients with Obesity/T2DM showed lower eGFR compared to their counterparts without T2DM ( p < 0.001) with a significant trend across the groups ( p = 0.035) (Fig. 1 ).
DRA in 1 cohort revealed a significant trend between sTG and SAH risk only in the linear model (Model 1, P = 0.035), with a decreasing risk of 54.0% (95% CI 5.5%~77.6%, P = 0.035) per mmol/L sTG increase (Fig. 5 D; Table 2 ).
There was a significant trend with average hours of night work per week ( P = 0.035), but no significantly raised risks for hours worked per night, nights worked per week, average hours worked per week, cumulative years of employment, cumulative hours, time since cessation, type of occupation, age starting night shift work, or age starting in relation to first pregnancy.