These associations were non-linear, but with a significant trend in odds of diabetes with increasing bilirubin among men (men: p-trend = 0.003, women: p = 0.34).
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Despite the clear impact of CIN on morbidity, healthcare costs, and hospital readmission, this study did not identify a significant trend in overall mortality (p = 0.352).
A Cox and Stuart trend test [ 48 ] also fails to identify a significant trend ( p = 0.37).
After controlling for other variables, there were no differences when comparing odds of ideation among females to males in the depression cohorts (OR = 2.3, 95% CI: 0.75–6.98; p = 0.14), nor was there a significant trend among age categories (p = 0.37).
Annual patient volume varied slightly but did not show a significant trend over time ( p = 0.39).
However, species evenness did not show a significant trend with spatial scale ( R 2 = 0.001, p = 0.395) ( Figure 1 C; Table S3 ).
Regarding beta diversity, we did not detect a significant trend over time in Bray-Curtis distance between same-subject NPMs sampled in consecutive time points ( P = 0.398; Table 2 ).
Although for p24 the linear regression did not reveal a significant trend (p = 0.400, r 2 = 0.18), there is a distinction between AA positions selected 2 or more times, which have a high probability of being towards subtype-specific population consensus (44%), and AA positions selected once, which have only a small probability of being towards the consensus (5%).
The average temperature of the four seasons did not show a significant trend ( p = 0.40–0.70).
However, we did not observe a significant trend in the osteocalcin to CTX ratio in response to ethanol in males of either species (rhesus: 0.4, p = 0.41; cynomolgus: 0.2, p = 0.71; Fig. 4 C).
The nonsusceptibility proportion for community-acquired, community-onset isolates showed a significant trend (p = 0.41), but this trend increased for healthcare-associated, community-onset isolates (5.4% in 2003–2007 and 12.1% in 2008–2013, p = 0.04).
A significant trend in genotype distribution was observed among participants aged 3.5 years or younger ( p for trend=0.0228), but not in the older age group ( p =0.4488).
Meta-regression by study quality did not demonstrate a significant trend towards higher-quality studies having a larger effect size (logOR = -0.04, 95% CI -0.16, 0.07, P= 0.45, Fig. 6 ).
After six months, we again found a main effect of response together with a significant trend for a response × group interaction with a medium effect size (response: F (2,60) = 23.47, p adj < 0.001, GG eps = 0.55, η 2 p = 0.45; response × group: F (2,60) = 2.96, p adj = 0.055, GG eps = 0.55, η 2 p = 0.092).
The unadjusted model revealed a significant trend in all variables for both sexes, except for female BP (P = 0.45 for SBP and P = 0.83 for DBP).
When the environment had high reward probability, the animal spent a smaller fraction of its search duration gazing at the novel fractal on no reward target trials (rho = -0.109, p < 0.001), and did not display a significant trend for reward target trials (rho = -0.0186, p = 0.454).
Moreover, an ordinal meta-regression across commonly applied thresholds (37.5, 50, and 75 nmol/L; REML) did not indicate a significant trend ( β = 0.17, 95% CI − 0.27 to 0.61; Wald χ 2 = 0.56; p = 0.455), with heterogeneity increasing slightly (τ 2 from 0.0165 at baseline to 0.0214; residual I 2 = 27.9%; adjusted R 2 = 0%).
The overall change in how residents perceived themselves after review of the comparison data—ie, viewing themselves more positively or more negatively than before—did not show a significant trend in one particular direction (z = 0.71, P = 0.48).
Similarly, total prescription counts in PMCs did not show a significant trend over time ( P = .49).
We did not observe a significant trend of increased alpha diversity ( P > .5) in samples from children with moderate-severe disease activity compared to mild activity ( Figure S2 ).
The percentage did not show a significant trend for CPs coming from psychoanalysis (0.03 per year, P = 0.506).
Salivary DHEA concentration did not demonstrate a significant trend with advancing age in boys or girls (ANOVA, P = 0.52 and 0.29, respectively).
For the ROM analyses, the weighted regression test (Egger’s test) indicated mild asymmetry in the true control comparison (t(16) = −2.84, p = 0.012), while the meta-regression test did not support a significant trend ( p = 0.520) ( Supplementary Figure S1A ).
Duhamel procedures for L‐HSCR did not show a significant trend over the study period ( τ = 0.159, p = 0.531).
A significant trend for activated CD8+ cells in blood was not found ( P = 0.54, Figure 3 B).