“a suggestive trend”

For genotype LR80, DNA vaccination reduced the overall probability of fish shedding, with a suggestive trend of the reduction being larger in single compared to mixed infections ( Figure 4 C; interaction virus × vaccine; LR80: Z 1,551 = 2.48, p = 0.013; Table S3A ).

Additionally, there was a suggestive trend of correlation between disease duration exceeding 10 years and FC between the left lobule VIIb and the left calcarine (R = 0.43, p = 0.034).

Indeed, in control conditions there is a suggestive trend for a decline in sociability over time (effect of trial = −65.03 ± 31.45, F 1,19 = 4.28, p = 0.052) whereas fish measured under the risk context exhibit no such habituation (effect of trial = −37.8 ± 32.6, F 1,19 = 1.34, p = 0.26).

3c ), with a suggestive trend for decreased TERT expression for the VNTR6-1-Long allele (β = − 16.97 TPM, p = 0.053; Fig. 3d ).

Intermediate ADNC, P = 0.001), and a suggestive trend between Intermediate and High ADNC ( P = 0.055).

Finally, in the analysis of the total MFI score, as shown in Supplemental Figure S4a and b, blood samples showed a suggestive trend toward an association with homocysteine degradation (Holm p = 0.057, FDR = 0.032), although this did not reach statistical significance.

However, we noticed that systemic MDA concentrations were significantly decreased following SCO administration in LOS pre-treated mice, as compared to the control group ( Figure 5 a, LOS + SCO versus Control, p = 0.043), and had a suggestive trend as compared to the injury-positive control (LOS + SCO versus SCO, p = 0.06), leading to the assumption that the angiotensin II receptors blockage could prevent SCO-induced lipid peroxidation traceable from the blood sera.

The Q3 group also exhibited increased mortality at 1 month (aHR 1.94 [95% CI 1.07–3.5], p = 0.03), with a suggestive trend at 1 year but not reaching significance (aHR 1.50 [95% CI 0.98–2.30], p = 0.06).

Furthermore, histomorphological assessment of plaques from the Athero-Express study cohort, encompassing parameters such as macrophage content, SMC content, collagen content, and calcification, revealed a suggestive trend towards heightened CCN2 expression in plaques exhibiting elevated levels of ACTA2 + SMC content ( P = 0.06), albeit not with other parameters ( Figure 7 E ).

However, Neflamapimod treatment led to significantly reduced cerebrospinal fluid (CSF) levels compared to placebo, particularly in T-tau [difference (95% CI): -18.8 (-35.8, -1.8); P=0.031] and p-tau181 [-2.0 (-3.6, -0.5); P=0.012], with a suggestive trend for neurogranin [-21.0 (-43.6, 1.6); P=0.068].

Nevertheless, MFI values exhibited a noteworthy progressive increase over the experimental periods ( p < 0.001), with a suggestive trend ( p = 0.074) for the interaction between the diet and period.

With regards to EGFR TP53 comutations, there was a suggestive trend towards higher prevalence in women (42/69, 60.87% vs. 15/33, 45.45%, p= 0.2007; q= 0.2007) in HR+ NSCLC.

Reductions in visceral fat, FBS, TC, TG, and LDL were greater than placebo but not up to significant levels; simultaneously, there was a suggestive trend indicating improvement from baseline to week 8.

Similarly, the pericardium area was not different compared to the control group, but there was a suggestive trend toward an increase ( Figure 4 C).

It is worth mentioning that the majority of (poly)phenols displayed a suggestive trend towards inverse associations with BW gain.

Instead of a quantitative LGE assessment, we found a suggestive trend qualitatively that patients with LGE just localized at the apical cap less frequently had malignant arrhythmia compared to those with dense LGE extending toward the level of obstruction.

There was a suggestive trend of an inverse association between longer duration of breastfeeding and dichotomous stromal CD24 expression (p-trend = 0.03) ( Supplementary Table 4 ), which, however, did not have a clear pattern.

26 Finally, there was a suggestive trend of association between levels of pDES and the growth of aortic root diameter in MFS.

In our multivariable model, we observed a suggestive trend with higher risks among survivors receiving etoposide within the HSCT with TBI group.

MMP-11 immunohistochemical score demonstrates a suggestive trend in association with disease-free survival, independent of Ki67 and other traditional prognostic factors.

On the other hand, there was a suggestive trend indicating that patients with high methylation levels of NKX6-1 might have an increased risk of developing MGL compared to those with lower methylation levels ( p = 0.062, Fig. 3 B), corresponding to a 1.7-fold increase in risk (HR = 1.73, 95% CI 0.80–3.75, p = 0.162, Table 2 ), which reached statistical significance considering the optimal cutoff value ( p = 0.021, Fig. 3 C, aHR = 2.01, 95% CI 0.93–4.33, p = 0.074, Table 2 ).

In line with our results, a pan-cancer study indicated that obesity and overweight status were associated with improved PFS and OS after ICI therapy, with a suggestive trend in a small subgroup of EC patients ( 19 ).

Emphasizing the gene’s significance, a African ancestry-specific eQTL, rs6008712, showed association with TTC38 expression in African Americans (AA) and displayed a suggestive trend in the broader GTEx liver cohort.

Additionally, the number of fusion segments also showed a suggestive trend toward interaction (p for interaction = 0.213), with patients undergoing multiple fusion segments having a slightly higher transfusion risk.

Specifically, among African Americans, there was a suggestive trend where ω-3 supplementation seemed to lower the risk of adenomas, hinting at a connection between ω-3 fatty acids and immune system adjustments.