For the multivariable Cox proportional-hazard regression model, we included factors that were significant or that showed a trend toward significance ( P < 0.1) in a univariable model and performed backward elimination ( P < 0.05) using the “standard method” of removing the variable with the largest P -value.
TSH and leptin levels did not change significantly during the study while mean insulin levels lowered from 6.8 μIU/ml to 6.0 μIU/ml, but it was only a trend toward significance ( p < .1) ( Table 1 ).
Variables that were statistically significant or showed a trend toward significance ( p < 0.1) in univariate analysis were included in an ordinal logistic regression model to identify independent predictors associated with higher Marsh grades.
Additionally, several covariates showed a trend toward significance (defined as P < 0.1).
Changes in the expression of five transcripts (TOB1, NR4A2, EGR1, TIPARP, and ADM) reached statistical significance ( p ≤ 0.05) as detected by qPCR, whereas changes in the expression of three other genes (CD69, PPP1R3C, and CXCR7) exhibited a trend toward significance ( p ≤ 0.1; Table 4 ).
Statistical significance was set at P < 0.05, and a trend toward significance was considered at 0.05 ≤ P < 0.10.
An exhaustive model selection process was conducted, evaluating all possible combinations of pre-operative and planned parameters that showed a trend toward significance in univariate analysis ( P < .1).
Statistical significance was declared at P values of <0.05, and a trend toward significance was considered at values of 0.05 < P < 0.10.
However, intraventricular hemorrhage (IVH) showed a trend toward significance (p = 0.1), suggesting a potential association warranting further study.
In addition, hemodynamic management/monitoring, strict urine output monitoring, enhanced diagnostic work-up, and fluid management (volume) resulted in a trend toward significance ( p < 0.1) for difference between High and Low level of CCL14.
Although it did not reach p<0.05 FDR corrected significance, there was a trend toward significance in the left lingual gyrus for the TIN>HL contrast as well (the region reached significance at p<0.1 FDR corrected).
However, channels 14, 23, 24, and 25 showed a trend toward significance (in terms of HbO 2 increase, P < 0.1).
Main effects were considered significant when P ≤ 0.05 and a trend toward significance when P ≤ 0.10.
Statistically significant p-values are shown in bold and underlined when they are below 0.05 or only in bold if a trend toward significance is observed (0.05 ≤ p < 0.1).
Furthermore, there was a trend toward significance for the PSFS ( F 2,16 =2.68; P =.10; η 2 g =0.21) (see Figure 7 for courses of functional improvement and Table S2 in Multimedia Appendix 1 for the frequency and improvements of the most common activities listed).
These were APH1B ( p < 0.05) and BAG6 , which displayed a trend toward significance ( p < 0.1).
With respect to the individual MRI components that composed the two MRDSS versions, only T1/T2 and BPF showed significantly increased severity in the cognitively impaired group ( P <0.05); GMF showed a trend toward significance ( P <0.10), and the moderate effect size for this difference approached the level seen for T1/T2 and BPF.
All variables included in the regression were significant ( p < 0.05) or showed a trend toward significance ( p < 0.10).
Several of these differences reached statistical significance or showed a trend toward significance (p < 0.10).
Variables that showed a trend toward significance ( P < 0.1) were included in the multivariate models.
(2022) found that two miRNAs, hsa-mir-4516 and hsa-mir-381-3p, exhibited a trend toward significance ( P < 0.1) ( 108 ).
For items showing a trend toward significance ( p < 0.10) in the Friedman test, post hoc comparisons were conducted using the Wilcoxon signed-rank test with Holm correction. 3.
Significance was set at p < 0.05, and a trend toward significance was recognized as p < 0.10.
Differences were declared significant at p < 0.05 and considered a trend toward significance at 0.05 ≤ p < 0.10.
A trend toward significance (the boundary of p -value < 0.2) was observed in the OS analysis for metastatic sites (only liver versus other sites, 103 versus 50 months, p = 0.14) while a prior systemic therapy showed a trend in favor also for the DFI (none versus ≥ 1, 14 versus 46 months, p = 0.1).