Barely Significant
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borderline significance

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borderline significanceP = 0.071.4× alpha
Six DEGs (PARP1, DUSP23, PCDH17, PSEN2, H3f3aos, EPHX1 ) located to the QTLs Perio 3 and Perio4 ( Table 1 , H3f3oas and Dusp 23 have no human orthologous and showed only borderline significance with P = 0.07). 15 DEGs had been reported in previous human GWAS on periodontitis with P < 9 × 10 −6 ( C1orf 87, HLA-DOA, BIRC 5 , CCDC 13 , GLDC, GPR 141 , OTOF, IFI 16 , ETNK 2 , TTLL 11 , ATP 5 S, GRID 1 , LBP, NIN , and VAV 1; Appendix Table 4 ) .
borderline significancep =0.071.4× alpha
In multivariable modeling of the association of these risk factors (including cervical dilation with borderline significance) with cesarean birth in this subgroup, labor duration of longer than 24 hours (RR 3.6, p =0.07) and likelihood of cesarean birth with each increasing centimeter of cervical dilation on admission (RR 0.8, p =0.07) had borderline significance.
borderline significanceP = 0.071.4× alpha
Similar to the results of primary outcome analyses, meta-analysis of the composite outcome of ‘cardiovascular death or hospitalizations (or urgent visits) due to heart failure’ exhibited significant improvement in response to treatment with SGLT2i at all the LVEF levels though again, compared to patients with LVEF above 30%, the subgroup of patients with the baseline LVEF of 30% or less showed a stronger response to gliflozins at borderline significance (HR: 0.69, 95%CI: 0.61 to 0.76 vs 0.78, 95%CI: 0.71 to 0.85; P = 0.07).
borderline significanceP = 0.071.4× alpha
Although the patients’ age attained borderline significance (adjusted RR 1.02 / year (95% CI: 0.998–1.034; P = 0.07)), head or neck location of the primary tumor (adjusted RR 2.2 (95% CI: 1.004–4.799; P = 0.48)) and a decreasing number of excised SLNs (adjusted RR 0.60 per SLN (95% CI: 0.417–0.874; P = 0.007)) turned out to be independent factors predicting false-negative results of SLNB.