Barely Significant
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borderline significance

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borderline significanceP = 0.061.2× alpha
Carriers of the rs4149601 GG-genotype together with the rs2288774 CC-or CT-genotype, as compared to non-carriers of this combination, displayed significantly lower P-renin and borderline significance for systolic salt sensitivity (P = 0.06–0.08) whereas there was no significance in diastolic salt sensitivity and Nt-proANP ( Table 3 ).
borderline significancep = 0.061.2× alpha
Interestingly, secondary analysis of data from a study of van Grootven and colleagues [ 47 ] revealed that among 86 patients aged 80 ± 7 years undergoing orthopedic surgery, the lowest intraoperative diastolic BP was the protective factor for POD (OR = 0.92; 95%CI 0.85–0.99, p = 0.03) and the protective impact of the highest systolic BP was of a borderline significance (OR = 0.97; 95%CI 0.94–1.0; p = 0.06).
borderline significancep = 0.061.2× alpha
After dichotomizing by median of CD8 IHC results, no association was found between pre-CCRT CD8 level and patients’ survival (Log rank test, p = 0.268 in Figure 3 C and HR = 0.66, 95% CI = 0.18–2.35, p = 0.52 in Table 4 ); however, there was borderline significance for those with lower post-CCRT CD8 level to have a longer survival period (Log rank test, p = 0.06, Figure 3 D and HR = 4.89, 95% CI = 0.96–24.92, p = 0.06, Table 4 ).
borderline significanceP = 0.061.2× alpha
We observed the same trends when we selectively analyzed the data from oligodendroglioma patients, though the differences in IFN-γ or TNF-α concentration between screening and day of surgery time points in arm 1 patients only achieved borderline significance because of the smaller number of cases ( P = 0.06, Supplemental Figure 4B ).