“did not reach statistical significance”

Elevated hs-CRP levels showed a trend towards poorer cognition in individuals experiencing SCD, though this did not reach statistical significance ( Zhang et al., 2023 ).

Responders based on Paris-I, Paris-II, and Rotterdam criteria showed a trend toward lower HCC risk than those of non-responders, although this difference did not reach statistical significance ( Table 4 and Fig.

The findings showed a slight trend toward faster improvement in skin symptoms, particularly rashes, among individuals receiving early RTX, although the effect did not reach statistical significance.

Protein levels of glutathione peroxidase 4 (GPX4), an enzyme that controls lipid peroxidation ( 25 ), showed a trend towards downregulation, but did not reach statistical significance ( Fig. 6 , F and I ).

The moderator test (QM = 7.78, p = 0.0999) indicated a near-significant trend, suggesting potential differences between intervention types, although the results did not reach statistical significance at the 5% level.

In contrast, neutrophil count (B = 0.714, P = 0.138) showed a positive trend but did not reach statistical significance, while monocyte count (B = 1.768, P = 0.362) was not significantly associated with preeclampsia.

Furthermore, the age at treatment onset showed a trend toward earlier initiation in the pandemic group (8.04 years) compared to the pre-pandemic group (8.65 years), although this difference did not reach statistical significance (p > 0.05).

A decreasing trend was observed in the Ln LSM values, although these did not reach statistical significance ( Figure 4B ).

The expression of monocyte chemotactic protein 1(MCP-1) and regulated upon activation normal T-cell expressed and presumably secreted (RANTES) was significantly increased in the aortas of KO mice, and that of vascular cell adhesion molecule-1 (VCAM-1) showed a trend of increase in KO mice although did not reach statistical significance ( Fig. 2 G).

Lobule V showed a trend towards smaller volume in CD patients, but the result did not reach statistical significance ( p = 0.082).

Other TP53 target genes ( Trp 53 inp1 , Mdm2 , Ccng1 , Phlda3 ) displayed a significant upregulation in the theca cells, while the ovarian stromal cells showed a trend toward increased expression, although this increase did not reach statistical significance.

Furthermore, although the difference between the groups did not reach statistical significance, the IL-6 plasma levels showed a trend reduction over time after the FS was administered (pre–post treatment 8.0 ± 1.73 pg/mL vs. 4.8 ± 1.20 pg/mL) but not after the placebo was administered (pre–post 5.6 ± 0.94 pg/mL vs. 5.01 ± 1.07 pg/mL).

Additionally, an increase in the INR showed a trend toward an increased risk of a poor prognosis, although this did not reach statistical significance (aOR = 2.14; 95% CI 0.93–4.96, p = 0.074).

Analysis showed a trend toward an overestimation of observed VAF with ≤ 2,000x depth for ≤ 0.003 VAF, although this did not reach statistical significance ( Fig 1C ).

Although inflammatory markers (IL-6, hs-CRP, TNF-α) did not reach statistical significance, both groups showed a trend of improvement, which may be related to exercise promoting the release of anti-inflammatory mediators and/or reducing the production of pro-inflammatory mediators.

However, RT‐qPCR analysis of Nod1 , NLR family CARD domain‐containing protein 4 ( Nlrc4 ), Nlrc5 and Nlrp10 did not reach statistical significance, although it showed an expected trend, possibly due to their subtle alterations or individual variation (Fig.

Compared to Q10, Q-Der consistently showed a trend toward better protection against oxidative stress markers such as mitochondrial superoxide, although this trend did not reach statistical significance.

The percentage of Annexin V–positive cells in TGF-β2–treated iFECD TCF4 −/− cells showed a trend toward reduction (19.8% ± 1.3%), although this difference did not reach statistical significance ( P = 5.28 × 10 −2 ).

While the PFD and LROF groups exhibited an increasing trend, these changes did not reach statistical significance when compared to the MOD group.

Conversely, as delineated in Table 4 , within the male cohort, irrespective of whether TyG Q1 or TyG Q2 served as the reference, the DR risk associated with TyG Q3 and TyG Q4 did not reach statistical significance, nor was a significant trend of increasing risk observed.

A decreasing trend in immune cell number was observed in the sample treatment groups compared to the LPS group, although this trend did not reach statistical significance ( Fig. 4A - 4D ).

Interestingly, the expression of mcBOX, a repetitive element, showed a trend towards upregulation in the H3K9M group, although the change did not reach statistical significance.

While the correlation between GDF15 and lean body mass and fat-free mass did not reach statistical significance, there was a positive trend observed (Figure S2-S3) (Table 2 ), suggesting that GDF15, as a target of metformin, plays a significant role in reducing sarcopenia traits and associated risks.

Biliary diseases significantly increased ICC risk (OR = 4.65, 95% CI: 2.5–8.75, P = .002), while HBV history showed a trend toward protecting against ICC but did not reach statistical significance (OR = 0.72, P = .078).

Particularly in case of p62 protein levels, there was an observed trend towards an increase following Ang-(1-9) treatment, though this change did not reach statistical significance ( Figure 2D ).