“did not reach statistical significance”

Trends in Mortality In-hospital mortality showed a decreasing trend over 2009–2024 based on meta-regression analysis; however, the reduction did not reach statistical significance (β = -0.012, p = 0.055).

Moreover, TH showed a trend for further improvement in Group 2, but did not reach statistical significance ( p = 0.096; Table 3 ).

Within SCC cases, PD-L1–positive tumors showed a trend toward increased CD8 + T-cell infiltration compared with PD-L1–negative tumors, although this difference did not reach statistical significance ( P = 0.063; Fig. 3G ).

Although digital interventions showed a trend toward improvement in executive function, this effect did not reach statistical significance [SMD = -0.41, 95% CI (-0.85, 0.02)].

Colonic Iba1 + myeloid cells showed a trend toward increased abundance, although this change did not reach statistical significance due to substantial interindividual variability.

Variables including numeric radiosurgery dose (HR = 1.35; 95% CI 0.99-1.87; p = 0.061) and loss of coordination at clinical presentation (HR = 2.74; 95% CI 0.94-8.02; p = 0.065) showed a trend towards association but did not reach statistical significance.

The total lymph node dissection time showed a trend toward reduction in the SHM group but did not reach statistical significance (114.00 vs. 125.00 min, P = 0.052).

Although moderate and severe myopia showed a trend toward greater residual myopia compared with mild myopia, these associations did not reach statistical significance.

In the detection of serrated lesions, although CADe showed a trend of superiority over other strategies, the advantage did not reach statistical significance.

Results of the meta-analysis In the randomized clinical trials, the FVC mean difference at 12 months between patients treated with CYC and patients treated with placebo or another immunosuppressant showed a positive trend in favor of the CYC group (mean difference = 4.15%), but did not reach statistical significance (95% confidence interval (CI) = -0.51 to 8.80; Figure 2a ).

For food-related stimuli, the Group × Time interaction for LPP amplitude did not reach statistical significance but showed a trend in the same direction.

Moreover, we observed an increasing trend of exacerbations in patients with T2 immunity, although these data did not reach statistical significance.

A meta-analysis of two studies of vitamin D supplementation showed a trend toward a reduction in preeclampsia with supplementation, but this did not reach statistical significance [ 24 ].

A multivariate model with overall stage, lymphovascular invasion, and CV did not reach statistical significance to predict overall survival, but showed a trend toward shorter overall survival with higher CV.

The wild-type 7D8 showed a trend of activity, but did not reach statistical significance compared to controls.

The PFS analysis did not reach statistical significance; however, we presume that it showed a trend of having a comparatively high HR in peritoneal recurrence and a survival curve under other recurrence sites.

Second, DKP/TRAM showed a positive trend over placebo in terms of first achieving an NRS-PI score < 4 or a pain intensity reduction ≥ 30% from drug intake up to 8 h after the first dose, but the difference did not reach statistical significance.

Among patients with known CAD, the difference in MACE rates between patients with elevated PWV and those with non-elevated PWV showed a trend toward significance, but it did not reach statistical significance (p = 0.053).

After adjusting for age, sex, and Frailty Index, the use of OAC showed a trend toward a lower risk of mortality, but this did not reach statistical significance (HR 0.52, 95% CI 0.21–1.25, p = 0.14).

Notably, some clinicopathological factors showed a trend toward differences between molecular subtypes, although they did not reach statistical significance.

The proportion of MyHC-I fibers in the KHE group was significantly higher than that in the KH group ( p < 0.05), while the decrease in MyHC-IIb fibers showed a trend but did not reach statistical significance.

Furthermore, although BTLA high memory B cell proportions showed an increasing trend after treatment and an inverse correlation with serum IgG levels, these relationships did not reach statistical significance, possibly due to insufficient statistical power related to the sample size.

For the primary outcome of 90-day mRS 0–2, compared with SoC, rt-PA significantly increased the proportion of functionally independent patients (RR = 1.21, 95% CI 1.06–1.38, low certainty), JX10 (RR = 1.50, 95% CI 0.87–2.58, very low certainty) and TNK (RR = 1.07, 95% CI 0.93–1.23, low certainty) showed a trend toward improvement but did not reach statistical significance.

In addition, at 15 minutes, VO 2 for RE showed a trend to be higher than that for CON, although it did not reach statistical significance ( p = 0.074).

An increasing trend was observed in the number of junctions and nodes and the total length of the network, although it did not reach statistical significance.