“highly significant”

The variation in ancestry seen in the admixture maps of Figure 1 also result in highly significant correlations of the three ancestries with altitude of birthplace (p-values <2×10 −16 for the three ancestries): African and European ancestry decreases with altitude (r of −0.24 and −0.39, respectively), while Native American ancestry increases (r = 0.48).

The genotype×broomrape race interaction was highly significant for TotAD ( F =3.17, P =2e-16), HeaAD ( F =2.96, P =2e-16), and NecAD ( F =3.63, P <2e-16) ( Supplementary Table S3 ).

Consistent with previous research ( 34 , 35 ), the RSA model predictions closely resembled listeners’ behavior, with the regression of listeners’ actual choice frequencies against model predictions being highly significant at the group level ( r = 0.89, P < 2 × 10 −16 ; Fig. 2A ) and across listeners (logistic regression coefficient = 5.84 ± 0.17, t 40 = 34.24, P < 2 × 10 −16 ).

Specifically, adjusting for African ancestry in a multiple regression model largely eliminated the highly significant effect of Black ethnicity on serum creatinine levels (decreased from P<2x10 -16 to a marginally significant P=0.05) whilst the highly significant effect of African ancestry on creatinine remained essentially unchanged when adjusted for Black ethnicity (P<2x10 -16 before and after adjustment).

gondii /THP-1 conditioned media resulted in a highly significant (P = 2x10 -16 ) increase in H . hammondi vacuole size ( Fig 7C ).

Effects of genotypes on pre-harvest aflatoxin contamination of maize Aflatoxin contamination was highly significant among maize genotypes (p < 2e-16) ( Table 15 ), with A2207–4 having the lowest level (1.33 μg/kg) and YANGA-5–2 the highest (7.65 μg/kg), as shown in Table 16 .

The microbial alpha diversity was significantly increased in gastric tumor compared with non-tumor tissues in three datasets P1, P3, and P4, with the exception of P2 which showed an opposite trend ( Figure S3A ), while the remaining datasets showed non-significant differences, resulting in a highly significant global Analysis of Variance (ANOVA; F -statistics: P < 2E−16) but a non-significant overall pairwise comparison ( P = 0.19).

In parallel, a linear model assessing the direct association between mean relative abundance and response demonstrated a highly significant positive effect (estimate = 0.30, P < 2.0e−16), with dataset terms again showing no significant influence (all P > 0.05), underscoring the robustness of abundance-based signals across cohorts.

The global TE family effect was found to be highly significant ( P < 2 × 10 −16 ).

Smooth terms for latitude and longitude were highly significant (p < 2 × 10−16), further confirming the spatial structure of life expectancy outcomes.

Thus, although the number of substitutions in a partition is a highly significant ( P < 2e-16) predictor of passing or failing any of the tests, that it explains only about a quarter of the variation suggests that other factors, such as underlying differences in the extent to which partitions violate the SRH assumptions, are driving the remaining ∼75% of the variation.

Importantly, the interaction between category and location was also highly significant (β = .165, t = 9.386, p < 2e−16), indicating that the correlation between VWFA‐2 and the IFC was significantly stronger compared to the other ventral ROIs.

We found highly significant differences ( p < 2 e - 16 ) between most cluster pairs at K = 5, except clusters 2 and 5 ( p ≈ 1 ) and clusters 2 and 3 ( p = 1.2 e - 09 ).

The Shetland Sheepdog ranked second in all models, and both Collies and Shetland Sheepdogs were highly significant according to the logistic regression model ( p < 2 × 10 −16 ).

An analysis of ChEMBL data demonstrated a highly significant relationship between bioactivities in human and rat targets ( R = 0.71, p < 2 e - 16 ), although outliers were identified for targets such as the Histamine H 3 receptor ( Kruger and Overington, 2012 ).

The categorical, as well as the smoothed fixed, effects were all highly significant ( p < 2 × 10 − 16 ).

The variance analysis showed a highly significant municipality effect ( p < 2 × 10 −16 ), and the multivariable GLM confirmed strong spatial heterogeneity in TIR. 4.

Females had significantly longer forearms (mean = 61.8 mm) than males (mean = 58.5 mm), with non-overlapping 95% confidence intervals and a highly significant t-test result (t = −12.68, p < 2 × 10 − 16).

We note that this overlap was highly significant ( Figure 2b , Fisher test P <2×10 −16 ), suggesting that age and tumor presence elicit common changes in the DNAm pattern of peripheral blood.

Result After controlling for baseline age, sex, education, APOE ε4 dosage, and self‐reported race, IFI44L genotype strongly associated with clinical trajectories in clinically normal (CN) individuals and those with mild cognitive impairment (MCI) in the ADNI cohort, with the rs273259 alternate (G) allele displaying a highly significant, dose‐dependent relationship with worse clinical trajectories (for CDR‐SB, in CN, p < 2 x 10 ‐16 ; in MCI, p = 1.1 x 10 ‐6 ; Figure 1A‐B).

The differences between transdifferentiation factors and all other TFs are highly significant (one-sided Kolmogorov-Smirnov (KS) test, expression p-value<2*10 −16 ; H3K27me3 p-value<2*10 −16 ).

This difference is highly significant ( Figure 2A , Figure 2—figure supplement 1 , p-value<2.10 −16 ).

Additionally, no effect of larvae stage was observed for NCR whereas the other factors were highly significant ( p value <2.10 −16 and 1.39.10 −8 for Paraquat concentration and NAC, respectively).

A paired t-test confirms that this difference is evidently highly significant (p-value<2.10 -16 ).

The haplotype (rs2004640T–rs2280714T) involved in both the alternative splice donor site and the elevated expression of IRF5 also had a highly significant association with SLE (pooled, P = 2.11 × 10 -16 ).