“highly significant”

This overlap was highly significant as represented by the odds ratio of 38.41-fold over what would be expected by random chance and the p -value < 2.16E-16 (two-sided binomial test).

Pearson's Chi-squared test showed that this difference is highly significant ( P < 2.2e − 16).

Note that likelihood ratio tests comparing the model results without and with the T1WP correction were all highly significant ( p < 2.2 × 10 − 16 ), probably due to the high number of observations and relatively small number of terms in the model.

5 a and b) and gene expression was highly significant for both root and leaf (root: R = 0.364, P < 2.2e-16; leaf: R = 0.334, P < 2.2e-16).

In addition, 82.5% of DMR-associated transposons are annotated as containing a transposable element gene, a highly significant enrichment compared with all annotated transposons (Fisher’s exact test, P <2.2e−16).

To further quantify these differences, we applied a two-sided Wilcoxon signed-rank test between the Mean and SD, which demonstrated a highly significant difference ( p -value < 2.2e-16, N = 12,321 compound-compound interactions).

The difference in the comparison of In100-element flanking exons and the control exon pairs is highly significant (Fisher's Exact Test, P<2.2×10 −16 , df = 1; Figure 4 ).

The difference between the nuclear area of cells from infected and uninfected plants was highly significant (based on the Brown–Mood median test, p = 2.2e-16), and the nuclear area of cells from P. brassicae -infected plants was 2.8 times bigger based on the median size.

While the difference between cases and controls is not significant (empirical P =0.070), we observe a highly significant overlap within each group ( P <2.2e−16 for cases and P =4.44e−16 for controls, Supplementary Methods , hypergeometric overlap test).

The structures look similar but the estimate of the covariate coefficient of the agency effect provided opposite significance results for the F-value (MCMC sample size = 4000): highly significant (p < 2.2e -16 ) vs. not significant (p = .405).

The overlap is very highly significant (Fisher’s Exact Test: Odds Ratio: 9.38; p-value < 2.2e-16).

However, all correlations were highly significant ( P < 2.2E-16).

Correlations between FPKM-corrected expression levels in same-sex replicate pools were highly significant for both the male ( r 2 = 0.830; Spearman’s ρ = 0.906 ; P < 2.2 × 10 − 16 ) and female ( r 2 = 0.869; Spearman’s ρ = 0.928 ; P < 2.2 × 10 − 16 ) pools.

We found that both up- and downregulated genes showed highly significant enrichment for association signals ( Z = 9.41, P < 2.2 × 10 −16 for genes downregulated by SUMO-1 depletion and Z = 3.43, P = 4.19 × 10 −4 for genes upregulated by SUMO-1 depletion; Figure 5 D).

There was a highly significant correlation (Spearman’s rho of 0.81, p < 2.2 × 10 −16 ) of the PBMC expression changes 6 h after HIIT and HBO 2 ( Figure 5 D).

The mean values of the non-invasively measured community-wide parameters obtained by DWCP seem to give a valid representation of the actual plant community as indicated by the highly significant positive relationship between the weighted plant biomass removed from sods and the digital biomass extracted from scans (quadratic polynomial regression, p < 2.2e-16, adjusted R 2 = 0.59, see Additional Figure 3 ), supporting results from scans of plant individuals ( Laxman et al., 2018 ).

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

This is a highly significant (p < 2.2 × 10 −16 ) excess (see Materials and Methods), suggesting some concordance in signal at the individual gene level.

The overall distribution of average within-pair DNA methylation differences showed a highly significant skew to the right in ASD-discordant twins ( P <2.2e−16, Kolmogorov–Smirnov test), with a higher number of CpG sites demonstrating a larger average difference in DNA methylation.

For 9 out of the 16 motifs we examined, the susceptibility of the vulnerable genes was strongly lower than that of the resistant gene sets to a similar degree, a difference that was highly significant (t-test, P < 2.2 × 10 −16 for all 9 motifs, Fig 5A columns shown in orange box).

In both cases the difference in expression level was highly significant ( p < 2.2e-16) indicating that the coverage of those genes was too low for an assembly of at least 55% in one species.

In fact, among the 291 genes selected for pad4 , 170 genes are also included in those for sid2 : the overlap was highly significant ( p < 2.2 x 10 -16 , Fisher’s exact test).

This difference was highly significant (Mann-Whitney test: U = 2.2×10 7 , P <2.2×10 −16 ).

The excess of GC to AT substitutions is highly significant, indicating non-equilibrium ( p < 2.2 × 1 0 − 16 ).

In the study, two ecologically competitive Functional Groups of golden pompanos were also found, with relative abundance showing a highly significant negative correlation ( R = -0.78, P = 2.2e-16) (Fig. 5 A).