“highly significant”

Specifically, comparisons between the ≥5-year group and both the 3–4-year and 0–2-year groups were highly significant (both p < 2 × 10 −16 ), as was the comparison between the 3–4-year and 0–2-year groups ( p = 0.0037).

As predicted, αsyn-O treatment generated an increase in the number of editing sites in all cultures (15.8% in astrocyte-only, 26.2% in neuron-only, and 11.1% in astro-neuronal cultures), which was highly significant (chi-squared P value < 2 × 10 −16 for increased exonic proportion in all cases).

The linear model is highly significant ( p -value < 2 × 10 − 16 ), and 62% of the ENL variance is explained by the time of development ( R a d j 2 ≈ 0.62 ), while the residuals of the model follows a normal distribution ( p -value 0.3375 in the Shapiro–Wilk test; see Supplementary SI.2 for details).

As for senior authorship, the difference between men and women was highly significant in both the 1999 (166 vs. 47, p = 2e-16), and in the 2009 cohort (188 vs. 115, p = 3e-5), but inspection of the absolute difference reveals that this difference is diminishing.

Females had significantly longer forearms (mean = 61.8 mm) than males (mean = 58.5 mm), with non-overlapping 95% confidence intervals and a highly significant t-test result (t = −12.68, p < 2 × 10 − 16).

This difference in wing length was highly significant (t = −57.479, p < 2e-16).

To determine the significance of the results, we fit three one-way analysis of variance (ANOVA) models comparing ssGSEA scores of CD4, CD8, and macrophage cell type markers, which were all highly significant ( p = 2 × 10 − 16 , p = 6.28 × 10 − 15 and p = 2 × 10 − 16 , respectively).

The molecular essence of all samples was consistent between measurements on the solariX and scimaX systems, with ANOVA revealing highly significant differences among sample groups ( p < 2 × 10 –16 ).

We found a highly significant relationship between NPAS4 affinity scores and NPAS4 ChIP-seq peak intensity (mouse and rat P < 2 × 10 −16 , Supplementary Fig.

The analysis of variance (ANOVA) results (Supplementary Data 1 –Table B 3 ) showed a highly significant effect of landmarks on measurement variance ( p -value < 2 × 10 −16 ); however, no significant effect of the operator ( p -value = 1.00) or the interaction between landmark and operator was observed ( p -value = 0.968).

We found 1341 of 4404 that passed QC in our own study (30.4%) were nominally associated with ethnicity (p<0.05), which represented a highly significant (p<2×10 −16 ) enrichment.

We repeated the moving average analysis (see Materials and Methods) comparing the distribution of mutations in the HS cluster and WT V regions and again found a highly significant positive correlation ( r = 0.52, P < 2 × 10 −16 ).

We found the effect of rurality to be highly significant ( P < 2.0 × 10 -16 ), but it explains only 28% of the overall variation in log positional error magnitude.

The analysis of variance showed a highly significant effect of genotypes ( p < 2 × 10 −16 ) (Table S4 ).

The Shetland Sheepdog ranked second in all models, and both Collies and Shetland Sheepdogs were highly significant according to the logistic regression model ( p < 2 × 10 −16 ).

Similarly, aphid counts and damage scores also showed a highly significant difference ( p -value = 2 × 10 −16 and 3.59 × 10 −14 ) ( Figure 6 C).

As for senior authorship, the difference between men and women was highly significant in both the 1999 (166 vs. 47, p = 2e-16), and in the 2009 cohort (188 vs. 115, p = 3e-5), but inspection of the absolute difference reveals that this difference is diminishing.

All pairwise comparisons were highly significant ( p ‐value < 2e−16), indicating that the distribution of Tajima's D values differs between every pair of populations. 3 Results From the DNA extracted from the six toe pads, we sequenced between 135,310,794 and 208,948,341 Illumina pair reads per sample.

We repeated linear regression analyses for the top significant CpGs in RUNX1 (cg12477880) and FLI1 (cg17239923), genes that are known regulators of hematopoiesis, adjusting for deconvoluted blood cell proportions instead of ReFACTor components (see “Methods”), and the associations with DS remained highly significant (both P < 2.0 × 10 −16 ).

Of these 316 genes, 81.5% (256) were found in our original list, a highly significant overlap ( P < 2 × 10 -16 , Fisher's exact test), demonstrating the reproducibility of our methodology.

An analysis of ChEMBL data demonstrated a highly significant relationship between bioactivities in human and rat targets ( R = 0.71, p < 2 e - 16 ), although outliers were identified for targets such as the Histamine H 3 receptor ( Kruger and Overington, 2012 ).

The variance analysis showed a highly significant municipality effect ( p < 2 × 10 −16 ), and the multivariable GLM confirmed strong spatial heterogeneity in TIR. 4.

We note that this overlap was highly significant ( Figure 2b , Fisher test P <2×10 −16 ), suggesting that age and tumor presence elicit common changes in the DNAm pattern of peripheral blood.

The intersection is statistically highly significant (p < 2 -16 ).

The first GLM, which included all values, returned a highly significant relationship between time spent in male germline and the observed substitution rates ( P < 2e-16; odd ratio 1.16, 95% CI: 1.1622–1.1626).