“highly significant”

Repeatability testing demonstrated highly significant inter ( k + 0.86, p < 0.001) and intra ( k = 0.74, p < 0.001) observer (intra-class) correlation coefficients ( k ).

NDF concentration showed a highly significant positive correlation with WSC concentration ( p < 0.001) and pH ( p < 0.01), but a significant negative correlation with LA concentration ( p < 0.05).

Overjet reduced by 5.10 mm which is statistically very highly significant ( p = 0.001).

Again we found a highly significant increase of total c-fos in fearful situation in Wt, as well as in 5-HT 1A (-/-) mice (Wt naïve 11.64±0.45, 1A-ko naïve 32.74±1.45, p≤0.001, Wt anxiety 179.9±4.6, 1A-ko anxiety 211.33±5.36, p≤0.001.) ( Fig 2A–2D ).

The effect of time was highly significant ( p < 0.001), but, the difference between the versions was not.

Statistical analysis confirmed highly significant group differences at both locations ( p < 0.001).

Quantification of the area under the curve indicated that nivolumab did not have a particularly prominent tumor suppressive effect on the PDO in co-culture ( Figure 3D ); however, our analysis of organoid tumor activity in co-culture indicated a highly significant reduction in PDO cell viability (P<0.001) after treatment with a high concentration of nivolumab compared to that in the control ( Figure 3E ).

It was seen that all the morbidities were more prevalent in EG, that is, Group A and the difference of prevalence of morbidities between Group A and B was found to be statistically highly significant ( P < 0.001), except the musculoskeletal disorders in which difference in prevalence was not statistically significant.

This single dose of indoxacarb produced highly significant reductions in geometric mean flea counts on treated cats throughout the entire 45 days of the study (P < 0.001, Table 1 ).

Clinical Global Impression (CGI) A highly significant treatment effect was found on the CGI scale, with a benefit of − 0.63 (− 0.84; − 0.47; p < 0.001, Suppl. 9.2.1) compared with the placebo, confirmed by the results from the SMM model − 0.67 (− 0.97; − 0.36, p < 0.001, Suppl. 9.3, Fig. 1 ), and found to be homogeneous among studies.

The Bartlett test of sphericity was highly significant ( p <0.001) for all domains.

Table 4 shows that the intervention group (Philips 66 with CBL) showed highly significant improvements ( p <0.001) with large effect sizes (Cohen’s d ranging from 0.597 to 0.635), demonstrating a substantial positive impact on all facets of clinical judgment as defined by the LCJR: Noticing, Interpreting, Responding, and Reflecting.

Frequency and intensity of side effects Available information from our analysis suggested a statistically highly significant relationship ( P value <0.001) between SARSCoV-2 vaccination and the following symptoms (Additional file 1 ): fatigue, malaise, headache, body pain, vision disorder, fever, chills and shiver, local pain in the hand, pain in the foot, loss of appetite, dizziness, crump/abdominal pain, arthralgia, chest pain, cough, shortness of breath, blurred vision, diarrhea, insomnia, jaw pain, earache, and bradycardia.

Furthermore, the VER155008 and ifosfamide combination resulted in a highly significant decrease in spinal tumor burden compared to control (P < 0.001).

A highly significant difference was observed in hemoglobin ( P < 0.001).

For preterm birth, there was no socioeconomic gradient in decade one in contrast to a clear gradient in later decades (Table 2 ), resulting in a highly significant interaction between TDS quartile and decade of birth (p < 0.001).

28 Similarly, approximately 63.2% of participants in this study cared for patients who received treatment from governmental hospitals; the caregivers of patients treated at non-governmental hospitals showed highly significant associations with anxiety (OR 6.3, 95% CI: [3.62–10.95], P = 0.001) and depression (OR 5.3, 95% CI: [8.28–19.32], P = 0.001).

When the RBS values are compared between control and diabetic groups, there was huge margin of increase in blood glucose, which was highly significant ( P < 0.001).

Impact of a Four-Week TOGU Training Program on FMS Scores Following four weeks of core and balance training, we observed that the total FMS scores of the 16 participants of the TOGU group showed a highly significant improvement compared to their pre-training levels ( p < 0.001, Figure 4 A); and the total FMS score after training improved by 11.48%.

Analyses of variance revealed a highly significant CS by preceding reminder type interaction ( F (2, 54) = 7.63, p = .001, η p 2 = .22); see Fig 4 .

The survey-weighted logistic regression yielded a highly significant model (Wald χ 2 = 182.4, p < 0.001) with a pseudo-R 2 of 0.29.

Results The mean serum cortisol level of the MPDS group showed a highly significant difference ( p < 0.001) from the controls.

IPA analysis on inbred lines found only two pathways as significant of which the ‘Role of BRCA1 in DNA Damage Response’ was found highly significant ( P < 0.001; with 20 of the 71 genes passing the cut-off criteria).

Highly significant differences were found between the ADHD and control groups for the variables ‘pain level’ (p < .001) and ‘pain location’ (p < .001).

Stratifying by age, the difference in the proportion of children with a TOS < 4 was highly significant between sCMV and CTL in children 7–10 years of age (91.2% and 18.7%, P < 0.001), but not in younger children (Fig. 3 d).