“highly significant”

Repeat IV administration of hMUT mRNA at 0.5 mg/kg every 2 weeks resulted in a pronounced and highly significant improvement in survival in severe MMA mice (n = 6/group, p < .001 from log-rank test, Fig. 3 a).

Statistically, only the family history showed a highly significant relationship with IEM ( p < 0.001) while the other risk factors such as age, gender, and consanguinity had no significant association [ Table 2 ].

The survival curves in -LN s and +LN s groups were 75% and 80.2%, respectively, with a highly significant increase in the relative risk of recurrence in the group -LN s versus group +LN s (21,15% vs 6.6%; p <0.001) ( Tab. 2 - 3 and Fig. 5 ).

Furthermore, we found a highly significant and moderate correlation between the two aspects “enough support during decision-making” and “satisfaction with the decision” (Fisher’s exact test, p = 0.001, n = 22; Cramer’s V = 0.683).

Comparing different samples (LDU, MJS, and XLS) in the bacterial communities, only the richness was highly significant with the location effect ( F = 283.34, p < 0.001; Table S3 ), the host tree effect ( F = 10.79, p < 0.001; Table S3 ), and the interaction effect of the location and host tree ( F = 3.97, p = 0.003; Table S3 ), respectively, whereas for the fungal communities, the richness, the evenness, and the diversity were all significant with these factors at different degrees ( Table S3 ).

Student’s t -test was used for the statistical analysis, and a value of P < 0.05 was considered statistically significant (*), P < 0.01 as highly significant (**) and P < 0.001 as extremely significant (***). .

The overall analysis of the 12 CVOTs showed a highly significant ( P =0.001) 8% reduction of MACE risk associated with no publication bias (Egger test, P =0.210) and significant heterogeneity (I 2 =45.8%, P =0.041), indicating the lack of homogeneity in the whole analysis that grouped 3 different classes of glucose‐lowering drugs.

Twenty four hour hypoxia treatment of 24 and 48 hpf embryos resulted in 3.4∼5.5 fold, highly significant increases (p<0.001) in IGFBP-1a mRNA levels and modest but statistically significant increases in IGFBP-1b mRNA levels (2.1 and 2.6 fold increases, p<0.01∼0.05).

An analogous analysis of response bias, showed a highly significant main effect of condition F (2,82) = 29.24, p < .001, η 2 p = 0.42, with a very large effect size.

A highly significant difference was observed between the two groups in terms of mean HbA1c levels ( P = 0.001), as shown in Figure 1 .

We observed a highly significant difference between the distributions of body color phenotypes among caterpillars raised on intact willow vs. intact birch ( Table 1, G = 745, P<0.001 ).

A particularly notable finding is the distinct preference for reliable sources among those who vaccinated their children, where 25.92% relied exclusively on reliable sources, in contrast to just 19.09% among those who did not vaccinate, with the difference being highly significant ( p < 0.001). 3.6.

Clutch size and nestling survival in non-predated clutches Laying date of the first egg had a highly significant negative effect on clutch size (model #4: − 0.178 ± 0.014 SE, t = − 12.8, n = 736, p < 0.001).

The probability ( p ) value was considered significant at a level < 0.05 and highly significant when p < 0.001.

Exposure of GT 1 -7 cells to H3 resulted in an increase in GnRH release at 1 h that became highly significant at a concentration of 1,000 nM H3 [100 ± 10.1 basal vs. 247.2 ± 8.3 (1,000 nM H3), data shown as %basal, P < 0.001 vs. serum-free medium] ( Fig. 6 ).

According to the analysis of hospitalization costs, material costs accounted for the greatest proportion of patients with PTB, followed by drug costs (Table 2 ). Multiple regression analysis revealed that the F value was 1377.916, indicating a highly significant relationship ( P < 0.001).

In Student’s t-test both correlations were highly significant (p<0.001).

However, during first follow up observations, patient reported QoL average scores upon VAS scale were 59.97 ± 6.79 in the control study arm with 63.11 ± 5.20 in the interventional study arm that was statistical highly significant values ( p < 0.001 , df-19.79).

The effect of study year on CPXV seroprevalence (by χ2/d.f.) was highly significant (χ 2 2 31.2; p<0.001); seroprevalence was 2.7 times higher among bank voles sampled in 2010 (36.1% [95% CI 31.7%–40.7%]) than in 2002 (13.1% [7.4%–21.0%]).

berghei –infected mice are treated with rTGF-β, there is a highly significant decrease in circulating levels of TNF-α (Fig. 5 a ; t >4.8, df = 8, P <0.001 at days 3, 7, and 10), and when mice are given anti–TGF-β antibody, serum TNF-α levels are significantly higher (day 7 after infection, control mice, mean TNF-α = 5.4 ± 0.5 ng/ml; anti–TGF-β mice, mean = 9.15 ± 0.92 ng/ml; t = 7.92, df = 7, P <0.0001).

The results of the two-way ANOVA for the relative theta cycle amplitude demonstrated highly significant effects for both time ( F 4,23592 = 137.27, p < 0.001) and potentiation ( F 2,23592 = 36.91, p < 0.001) factors, as well as for their interaction ( F 8,23592 = 5.24, p < 0.001).

Compared to the 1:0 group, the neutralizing effect of CPA-VHH on the phospholipase activity was highly significant in the 1:15 group ( p < 0.001, Figure 3 A).

Trade-offs and synergies between ESs There is a similarity in the trade-offs and synergies between ESs at the county and sub-watershed scales, with most ESs showing a highly significant positive correlation ( p < 0.001).

The Phase III studies reported a modest, but highly significant ( P <0.001) mean absolute improvement in FEV1% of 2.6–4.0% compared to placebo at 24 weeks.

Comparing the distance between sulci alares nasi at the transition point to the philtrum (P5–P6), a highly significant difference could be found when comparing the groups ( p < 0.001).