SNP associations were genome-wide significant with CC-BNT (P<2.4×10 −7 ) and CC-WRAT (P<1.0×10 −8 ), nearly genome wide significant with CC-LMI (P<6.0×10 −7 ), and highly significant with CC-LMD (P<1.3×10 −6 ), CC-HVOT (P<1.9×10 −6 ) and CC-TMTB (P<3.7×10 −6 ).
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Incorporating domain specific feature extraction further improves its performance to an AUC of 0.855, which is highly significant (p = 1.3E-06).
p -values for most porphyrins were highly significant (uroporphyrins p = 1.3 × 10 −6 , pentaporphyrins p = 9.21 × 10 −8 , total porphyrins p = 2.61 × 10 −5 ) when comparing the youngest (≤5 years) and oldest (>10 years) age groups.
At the end of the study (165 days), after three dosing cycles of E5, we observed highly significant improvements in TNF-alpha levels (Student’s T test p = 1.3 × 10 −6 for males and p = 7.6 × 10 −5 for females) and IL-6 levels ( p = 4.1 × 10 −6 for males, p = 3.4 × 10 −6 for females, Supplementary Fig. 14 A–D) in the blood of E5-injected rats over that of saline controls.
Quantification shows controls have 7.8 ± 1.0 projections/bend whereas dfmr1 nulls have 17.8 ± 1.2, a highly significant elevation ( p = 1.3 × 10 −6 , two-tailed unpaired t test; Fig. 3 b, left).
Within the Detected group, the difference between global methylation levels in PLWH and SN was highly significant at Visit 2 (post-HAART, p = 1.3 × 10 −6 ; Welch’s t -test comparing mean CpG values in each PLWH group to their matched SN controls), while within the Undetected group, the mean difference in global methylation between PLWH and SN and the significance ( p = 0.015) were diminished. 3.3 GREAT functio
Highly significant differences between both Andean wild and Andean domesticated accessions ( p-value = 1.314e-06, Wilcoxon test) and between Mesoamerican wild and Mesoamerican domesticated accessions ( p-value = 0.011, Wilcoxon test) were observed.
However, there was a highly significant difference in rank changes between the MSR and FSM management regimes (P = 0.00000132, Welch’s T Test, Two-tailed).
By contrast, there was a strong and highly significant association between genodermatosis subtypes and inheritance pattern ( p = 0.0000013378; adjusted p =0.0000053512; Cramér’s V = 1.000) ( Table 3 ).
BMI is also strongly correlated with SES ( Figure 2 ) but the association of BMI with disease remains highly significant even after accounting for SES and ancestry ( c BMI = 0.09241, P = 1.34 × 10 −6 ).
Only one patient in the cohort predicted not to recur (n = 8) experienced biochemical recurrence 126 weeks post-prostatectomy, a highly significant result (p= 1.38×10 -6 , log-rank test).
In contrast, the internal DNA reads did not follow a normal distribution, with a distinct group of over-represented, or enriched bins which was highly significant (p = 1.382 × 10 −6 ; Fig. 4e,f ).
Overall paired comparisons across the five irradiation scenarios demonstrated highly significant differences for both the mean blood dose and the mean circulating lymphocyte dose (Friedman test: χ 2 = 646.4 , p < 1.39 × 10 − 6 and χ 2 = 638.8 , p < 6.30 × 10 − 6 , respectively) (Data Supplement).
Using Table 6 of that publication, it is possible to calculate the association of lupus anticoagulant (LA) with FVL both in women with recurrent pregnancy loss and in controls, and this association was highly significant for both groups (χ 2 test, P = 1.4 × 10 -6 , for the combined groups: 26 LA-positive women out of 43 women with FVL, compared with 46 LA-positive women out of 209 controls).
These differences were highly significant for both Proteobacteria and Firmicutes (paired t -tests P = 1.4 × 10 −6 and P = 8.4 × 10 −6 , respectively).
This effect remained highly significant when excluding three outlying cases with the strongest coefficients ( β : M = −0.09, SD = = 0.05; t = −7.44, p = 1.41e-06).
Also, the level of education of the clients had a strong statistical association with the pattern of their substance use, i.e., differences in the proportion of mono- and poly-drug users clients for different levels of education was highly significant (p=0.00000144).
Unlike our highly significant findings, where adjusted R2=0.610 and p= 1.45E-06, Kumar et al “did not observe the statistically significant association of mean temperature and spread of the COVID-19” (6). c.
It is interesting to note that rs12237222 is in weak but highly significant linkage disequilibrium with rs11139451 ( D ′ = 0.257, P = 1.45 × 10 −6 ) that has been found to show the maximum HLOD score in the study of Allen-Brady et al.
One-way ANOVA confirms a highly significant effect of infill density on PETG tensile strength (F(2,6) = 259.76, p = 1.49 × 10 −6 ).
The difference between the 2 genotypes was again highly significant ( P = 1.5 × 10 −6 ; n = 11).
In contrast, AF3 exhibits no meaningful separation between binders and non-binders (AUROC = 0.45), and the difference in performance between the two models is highly significant (DeLong test, P = 1.5 × 10 −6 ).
In addition, a highly significant Spearman correlation (Spearman rho = 0.49; p = 1.5e−6) was observed between the normalized supernatant growth effects and the inferred gLV inter-species interaction parameters.
Although they do not pass correction for multiple testing in this analysis, the sites in SCN7A and IQANK1 remain highly significant (unadjusted P =.0000015 and .0000035, respectively) and are among the top 10 most significant sites.
Alternative alleles for another family member, Sb02g029725 ( SbFT6 ), mapping near another flowering QTL, also showed highly significant association with photoperiod response index ( P = 1.53×10 − 6 ).