“highly significant”

These studies had highly significant heterogeneity ( P < 0.00001, I 2 = 91%), so a random-effect model was used to calculate pooled SMD.

Higher birefringence was measured in fascicular regions of picrosirius red stained sections relative to matched unstained sections in both tendon types, and these differences were highly significant ( p < 0.00001 for both SDFTs and CDETs).

demonstrated that Nadi Shodhana Pranayama showed a significant decrease in auditory reaction time (ART) (p = 0.01), and Bhramari Pranayama showed a highly significant decrease in auditory reaction time (ART) (p < 0.00001).

There was a highly significant correlation between staining intensity and the percentage of positive cells for EGFR as well as pl85HER-2 (Spearman; rs=0.83, P<0.00001).

This is a highly significant increase over previous levels ( t = 14.79, df = 94, P<10 −5 ).

For a test, we conducted chi 2 tests for some of the variables, but, as assumed, all results were highly significant (e.g., “gender”: chi 2 : 695303.9042, p < .00001).

Dunn’s post hoc test showed highly significant differences between the intermediary and dry periods ( p = 0.00001) and between the rainy and dry periods ( p = 0.000001).

With 10, 000 random permutation test, we confirmed such an enrichment of genes with higher expression variability in YRI is highly significant (P<10 −5 ).

An initial Pearson correlation analysis indicated a highly significant association with Nonpareil diversity and pH ( R = 0.51, p < 1 × 10 −5 ), along with weaker correlations to several other parameters.

Between the Non-Gly and the Gly subtypes, we identified 763 highly significant Differentially Expressed (DE) genes (Adj. p < 1E-05), 296 of which over-expressed in Gly subtype and 466 over-expressed in the Non-Gly tumors ( Figure 2A and Supplementary Table 3 ).

The functional cluster F1 (Left Superior Temporal gyrus + Cingulate Gyrus + etc., see Table 3 ) was highly significant ( p < 10 −5 ) with all structural clusters.

A total of 21 children with PSTC and 518 children with migraine showed that drawings had similar features except one-third (28.6%) with PSTC depicted diplopia which was highly significant ( P = 0.00001).

Among the top most highly significant pathways ( P < 1.0 × 10 − 5 ) included the pathways involved in MSP-RON, PDGF, molecular mechanisms of cancer, STAT3, prostate cancer, P53, MYC mediated apoptosis, IGF-1, NF-kB, Androgen biosynthesis, PTEN and IL-6 signaling pathways (Fig. 5 ).

Similarly, in FA3, the ettringite content showed highly significant increases from 0.03% to 0.24% by aging (Z = 11.24, p < 0.00001).

The Fst values were relatively high and reached highly significant levels (p < 10 −5 ) between populations from Tak (all collection periods) and Yala-Narathiwat (21.75%), and between Ubon Ratchathani and Yala-Narathiwat (19.44%), implying genetic differentiation or limited gene flow between these endemic areas.

All hotspots exhibited highly significant one-sided binomial test P -values (all P < 1 × 10−5), supporting strong enrichment (Table 2 ).

Subgroup analysis was highly significant ( p < 0.00001, I2 = 94.1%), clarifying that digital exercise improved ASMI compared to “maintain original lifestyle” but was comparable to “offline exercise”.

In the second International Study of Infarct Survival (ISIS-2) in patients with ST segment elevation myocardial infarction (STEMI), the use of aspirin as opposed to placebo was associated with a highly significant reduction in vascular mortality (9.4% versus 11.8%, P < 0.00001) along with significant reduction in rates of reinfarction (1.0% versus 2.0%) and nonfatal stroke (0.3% versus 0.6%) at five weeks. 6 Blockade of the P2Y 12 subtype of adenosine diphosphate (ADP) receptor on platelet cell membranes ( Figure 1 ) has been established as another key mechanism of platelet inhibition.

The strikingly different microsatellite distribution in isolates carrying a resistant or a sensitive haplotype was highly significant (chi-square test P < 0.00001).

Importantly, this was supported by our data with a highly significant decrease in CSF acetylcholine levels (Figs. 2 , 3 , and Table 3 , 0.36-fold change, p <0.00001).

However, the differences in mean distances within the groups were highly significant ( F = 128.13, P = 0.00001) [ Table 5 ].

There was a highly significant difference in composition by weighted UniFrac analysis ( p < 10 −5 ) (Fig. 3 b).

The mean of the MICs, 0.71 (range: 0.66 to 0.76, n = 166 for each), was highly significant, p < 0.00001 (SD across the 18 MICs = 0.03, 95% CI [0.72, 0.69]).

3G was highly significant ( P < 10 − 5 , Fisher’s exact test).

Four of the 142 sequenced genotypes were identified as outliers along four different and highly significant axes of variation ( P < 10 −5 from tests based on the Tracy–Widom distribution) based on the default settings of the smartpca program within the EIGENSOFT package ( Patterson et al. , 2006 ).