“highly significant”

When the statistic test was applied only to saliva, lingual plaque, and supragingival plaque data, the differences in the microbiota between individuals was highly significant (repeated measures ANOVA, P < 0.0001).

A regression analysis of calving pattern and total cost of rearing also showed a highly significant difference ( P <0.0001) between the cost of rearing on all-year-round calving herds and spring and autumn calving herds (data not shown).

This difference is highly significant ( p < 0.0001).

Both the paramagnetic media concentration and the applied current led to highly significant changes in the levitation heights of live and dead cells ( P < 0.0001) ( Fig. 4 C ).

Pearson correlation analysis between qRT-PCR (ΔΔCt method) and RNA-seq (log2FC) data revealed a highly significant positive correlation (Pearson’s r = 0.965, R2 = 0.984, 95% CI: 0.942–0.991, p < 0.0001), demonstrating strong consistency between the two platforms.

As presented in Table 7 , the ANOVA results indicate that the factors of models A, B, C, D, AC, BC, BD, CD, A 2 , B 2 , and C 2 are D 2 < 0.05 (at the 95% confidence level, p < 0.05 was considered statistically significant and p < 0.0001 was considered statistically highly significant) [ 14 , 20 , 21 ], indicating that the effects of the nitric acid concentration, leaching temperature, liquid–solid ratio, total pressure, as well as the interactions between these factors and their squared effects on the vanadium leaching efficiency were significant.

The mean difference was statistically highly significant (P < 0.0001 ** ) on applying Mann–Whitney U test.

In general, mean refraction demonstrates a highly significant shift towards less hyperopia with increasing age (p < 0.0001) from 0.73 ± 0.1DS for 4 year olds to 0.21 ± 0.11 for 12 year olds, however this is more noticeable after the age of 9 years as seen in Fig. 1 .

The difference was highly significant ( p < 0.0001), exceeding the trial’s efficacy threshold.

In contrast, zoledronic acid exhibited highly significant correlations for cell inhibition and TNF-α stimulation (r = 0.454, p < 0.0001), cell inhibition and RAP1A inhibition (r = 0.556, p < 0.0001), and TNF-α stimulation and RAP1A inhibition (r = 0.499, p < 0.0001).

We found a highly significant positive correlation (r, 0.74; P < 0.0001) between both methods based on 192 individual measurements conducted with each of both methods (Supplementary Figure 1 ).

The binomial probability of ⩾6 out of the 16 independent events (in this case Fisher g -tests) occurring, each with probability 0.05, is very highly significant ( P <0.0001); however, not all the end point groups we consider, and therefore not all the statistical tests, are statistically independent.

We observed a highly significant effect of genotype ( P < 0.0001, H 2 = 0.23) in ovariole number CV E , but could not detect a genetic component of variance in ovariole asymmetry CV E ( H 2 = 0; P = 0.65) ( Figure 2 and Table S3 in File S2 ).

Screens of 11 known antibiotics and other drugs revealed that Fexinidazole, Corallopyronin A and Rapamycin reduced the number of Wolbachia clusters infecting sheath cells but only Fexinidazole and Corallopyronin A showed a highly significant difference (p < 0.0001) compared to the control group.

The difference in aPTT values was highly significant (p < 0.0001), as was the difference in TT values (p < 0.0001), indicating stronger divergence in blood bank plasma samples.

The difference in survival expectance between patients with high-risk score and low-risk score was highly significant (p<0.0001).

The NIHSS score at admission and the mRS score at discharge were shown to be directly proportional to each other, with a highly significant link (Spearman correlation coefficient = 0.7799; p=0.0001).

There was also a highly significant (P<0.0001) difference in the IMA levels amongst the two types of malaria; falciparum (0.69 ± 0.05) and vivax (0.44 ± 0.06) ABSU ( Figure 2 ).

In addition, the Chi-squared test demonstrated a highly significant association between SIRS and complications (χ 2 = 21.01, DF = 2, p < 0.0001) ( Figure 3 ).

A highly significant correlation ( ρ 0.43, p < 0.0001) between cyclin D1 mRNA and protein expression has also been reported [ 29 ].

According to analysis of inferred metagenomic functional content using PICRUSt algorithm, a highly significant discrepancy in metabolism and immune functions ( P < 0.0001) was predicted in the obese group.

However, oral administration of PPBE at both doses of 200 and 400 mg/kg B.W showed a highly significant increase in urinary output as compared to the control and furosemide groups (p<0.0001).

The effect of the factor ‘year’ was highly significant ( P < 0.0001).

Quantification of Gag clusters at the ventral PM of DMSO (n = 27) or rCD1 treated (n = 26) cells revealed a pronounced (80%) and highly significant (p<0.0001) reduction of Gag clusters in PM PI(4,5)P 2 depleted cells compared to control cells ( Figure 1F ).

The overall model was highly significant ( p < 0.0001), indicating that bacterial concentration and assay configuration together explained most of the variability in signal.