“highly significant”

This corresponded with highly significant (MM200, Me4405, Mel-RM p < 0.0001, Sk-mel-28 p = 0.0008) increases in XPC mRNA expression in all cell lines (1.27-7.93 fold increase) (Fig. 1b ).

We found a highly significant interaction between the occurrence of native versus non-native amphipods and upstream distance ( Chi 2 value = 16.03, p value <0.0001; Fig. 1 ), reflecting that non-native species were mostly present at the outlet, while the native species were mostly present at the further upstream sites.

The M group demonstrated the smallest reduction (p< 0.05), whereas differences in the other groups were highly significant (p< 0.0001) ( Figure 8B ).

Highly significant differences were observed between the various range intervals ( X 2 = 433.4, p < 0.0001).

The genetic differentiation among the populations was high (F ST : 0.28) and found to be highly significant ( p < 0.0001).

Furthermore, quantification revealed a highly significant ( P = 0.0001) fourfold reduction in the average number of Kyn + cells in D-1MT–treated animals ( Fig. 3 B ).

The frequency of MN induced in bone marrow erythrocytes of Cd exposed toads was highly significant ( p <0.0001; r=0.69) with 1.93, 2.31, 4.63, 6.16 and 9.00 folds (corresponding to 5, 10, 25, 50 and 75 % of Cd concentrations respectively) increase than the negative control (Figure 2 (Fig. 2) ).

Whereas phagocytosis in the presence of heat-inactivated serum from NHD showed no significant association with LPC concentrations (not shown), a highly significant negative correlation ( r = –0.556, p < 0.0001) between LPC levels and phagocytosis in case of heat-inactivated serum from patients with SLE was observed (Figure 5 B).

To determine whether age at spontaneous puberty and age at the start of GH in patients with TS are associated, we performed a correlation analysis, revealing a highly significant correlation between age at the start of GH treatment and age at pubertal onset [correlation coefficient 0.65 ( p -value < 0.0001)], which explained 32% of the variability in spontaneous puberty with age at GH start [intercept = 10.3 years ( p < 0.0001), slope = 0.31 ( p < 0.0001)].

Overall, recombinant MUP treatment had a highly significant effect on the release of these VOCs from urine streaks (multivariate analysis of variance (MANOVA), effect of treatment: F 9,105 = 4.32, p < 0.0001).

All tests yielded highly significant results, with p -values < 0.0001, providing strong confidence in our findings (Supplementary Table 4).

Specifically, SPAV and STotalAV were highly significant (p<0.0001) in the untreated group, while losing significance in treated patients (p>0.05).

Two-way ANOVA shows highly significant differences [F(1,24)=31.5, p<0.0001] between HAT genes expression in controls and embryos injected with well described Dystrophin morpholino cocktail (also see Materials and methods, S1 Fig A ).

ANOVA results indicated a highly significant model, as demonstrated by an exceptionally high F-value of 644.09 and a low probability value (p-value < 0.0001), underscoring the reliability of the developed model (Table 5 ).

Urea, ALT, AST and AFP were highly significant in post-hepatitic HCC patients than control group (P ≤0.0001).

All of these effects were highly significant ( P < 0.0001).

This observation was confirmed by the two-way PERMANOVA, which crossed swabbed region with health, stating that there were highly significant differences between regions and globally between health states (pseudo- F = 22.241, p -value = 0.0001, pseudo- F = 10.373, p -value = 0.0001, respectively) (Supplementary Table S1 ).

The difference is highly significant (mean number of kin: 16.4 ± 11.9 vs 5.8 ± 8.8; F 1,322 = 82.72, p < 0.0001).

The likelihood ratio test confirmed that this threshold effect was highly significant ( p < 0.0001), supporting its reliability.

Additionally, linear models assessing the importance of location in describing the canonical function generated from linear discriminant analysis were highly significant ( R 2 = 0.857, p < 0.0001). 3.2.

We first compared the effects of the cytosolic PLA2 inhibitor AACOCF3 on macrophage cytokine production in response to TBWCL and identified a highly significant effect on Mtb-induced TNF secretion at the 10 μM dose ( Figure 2C ; P < 0.0001).

HDL-C Patients that died had a highly significant lower serum HDL-C on day 1 of ICU admission (p < 0.0001, meta-analysis t-distribution) with a pooled mean difference of −7.06 mg/dL (95% CI −9.21 to −4.91 mg/dL) across 17 studies with 1542 participants 17 , 20 , 22 , 31 , 32 , 34 , 36 , 37 , 40 , 41 , 43 , 45 , 46 , 47 , 48 , 50 , 51 ( Fig. 3 ).

Likewise, we were able to demonstrate the highly significant influence of lymph node status on patient survival, not only on disease-free but also on overall survival (log rank P < 0.0001, Cox P < 0.0001).

Analysis of variance revealed a highly significant effect (p<0.0001) of the microphone setting.

The results show highly significant (P<0.0001) inputs on the outputs as the delta-PSI, MR, and the SN values according to the statistical significance (P, 2 tail) analysis, as seen before in the sensitivity analysis.