“highly significant”

The average sum is much smaller for Model 1 than for Model 4 and the differences between natural and simple design are highly significant (p<10 −36 , Welch's t -test).

We find a highly significant difference between these two means [t-test: t (478) = −13.618, p = 1.51×10 −36 ], indicating that, on average, observers are able to estimate admixture levels from photographs better than chance.

The observed 1.8‐fold enrichment was highly significant (Fisher's exact test, P = 1.90 × 10 −36 ).

The correlation between mean catch-up saccades per second and microsaccades rate was moderate, with a Pearson correlation coefficient of r = 0.58, a 95% confidence interval of [0.51, 0.64], and a highly significant p-value ( p = 1.99e-36).

Although this genetic risk score shows a highly significant association in Caucasian ( P =3.94 × 10 −36 ), there is no evidence of association in the Chinese population ( P =0.21; Fig. 5 ).

Coexpression of CD47 and IFT57 mRNAs Is Intrinsic to Cancer Cells A highly significant positive correlation was also observed between CD47 and IFT57 mRNA expression across the 1156 cell lines in the Cancer Cell Line Encyclopedia (CCLE) [ 26 ] ( p = 4.6 × 10 −36 , Table 1 , Figure 1 d).

The read accuracy improvement of using ORP over single reads, revealed as a gap between their respective error profiles, was most prominent at Q10 and diminished with higher Q-score filtering; the advantage at Q30 was small yet still highly significant (two-sample Kolmogorov-Smirnov test p = 5×10 -36 and 2×10 -11 for rabies and BCV control, respectively), as any reduction in error rate can be used to detect viral variants with greater sensitivity.

The correlation of IVW analysis is highly significant (β = −0.16, P = 5.91 × 10 −36 ).

These contrasting strategies are highly significant ( P < <0.001, Welch’s t- test, t = 54.6, P = 6 × 10 −36 ; n = 18 for D-lactate, n = 20 for L-lactate) and likely alter competitive dynamics in lactate-limited systems.

Our analysis revealed a highly significant correlation between the 12-protein panel and the classical AD biomarkers (297_CSF: positive correlation: Aβ 42 , R = 0.31, P = 7.5e-0.8; Aβ 42/tau , R = 0.64, P = 6.6e-36; negative correlation: p-tau, R =-0.62, P = 7.5e-33; t-tau, R =-0.76, P = 2.4e-57; Fig. 3 A).

We observed a marked elevation of EP300 protein abundance in HCC tissues compared to adjacent normal liver tissues, with a highly significant difference ( p ≈ 7.60 × 10^−36, Fig. 1 D).

This enrichment is highly significant with a P < 7.98E-36 using the hypergeometric test.

The overlap of the downregulated genes in strains overexpressing the D303A or D346A variants compared to those in the strain overexpressing wild-type RNase E was statistically highly significant ( P < 10 –35 and < 10 –46 , respectively, hypergeometric test).

rs13038305 in relation to plasma cystatin C and creatinine based measures of GFR In the MDC-CC, each copy of the major allele of rs13038305 was associated with a highly significant (P<1 x 10 −35 ) approximately one third of a SD increase of plasma concentration of cystatin C both in model 1 and model 2.

The results showed pathways involved in repairing damaged nucleotides/DNA as highly significant in determining alkylating agent sensitivity: the Fanconi anemia pathway, ( p = 1.04 × 10 −35 ), homologous recombination (2.00 × 10 −24 ), nucleotide excision repair (2.77 × 10 −9 ), and non-homologous end-joining (1.04 × 10 −7 ) ( Figure 6 ). 3.

Of note, in agreement with the known relationship between ΔAUC CP /ΔAUC GLU and GLUSENS in the general population, in our population of renal transplant patients, we also observed a quite high correlation between the two, as mirrored by the highly significant p -value ( p = 2.22 × 10 −35 ).

The average methylation level of the 4 hyper-methylated genes showed highly significant difference between breast tumor and matched normal tissues ( P = 3.54E-35) (Figure 1 ).

The different response to hc‐IEDs for sample entropy and delta power was highly significant ( p = 6.3 × 10 −35 , Wilcoxon rank‐sum test).

This may be the source of the highly significant association signal we observed in our dataset for all three genetic models (DOM: P = 9.33×10 −35 ; ADD: P = 7.48×10 −30 ; REC: P = 5.27×10 −6 ).

However, a single SNP on chromosome 9 (at position 20,550,439) was noticeable for its strong and highly significant effect (P = 10 −34 ).

Although the performance gain was quite small when DNA shape was already included in the model, it was highly significant ( P < 1.549 × 10 −34 for sequence+MGW+EP versus sequence+MGW models; P < 4.569 × 10 −41 for sequence+shape+EP versus sequence+shape models; P < 6.748 × 10 −4 for sequence+3shapes+EP versus sequence+shape).

There was highly significant non-independence ( P-value = 1.8 × 10 −34 ) between the two predictions, driven primarily by the large proportion (66%) of SNPs predicted to be benign by PolyPhen and tolerant by SIFT.

In the liver, six highly significant modules were identified ( Figure 4 A–D and Figure S6 ): MEbrown (cor = 0.85, p = 2.3 × 10 −34 ; transcripts no. = 119), MEblack (cor = 0.83, p = 1 × 10 −200 ; transcripts no. = 925), MEcyan (cor = 0.54, p = 0.0012; transcripts no. = 33), MEsalmon (cor = 0.63, p = 8.5 × 10 −05 ; transcripts no. = 33), MEgreen (cor = 0.68, p = 3.1 × 10 −22 ; transcripts no. = 154), and MEgreenyellow (cor = 0.34, p = 0.049; transcripts no. = 34) ( Figure S7A–F and Figure 4 E–K).

A second, highly significant set of associated variants in 1q32.2 was defined by the lead SNP rs570516915 ( P = 5.25 × 10 –34 , OR = 8.65, Fig. 2b ).

After using k-means clustering to assign individuals to two different groups according to their coordinates in the PCoA, a highly significant association ( P = 5.41 × 10 -34 ) between the k-means assignments (n cluster1 = 531, n cluster2 = 118) and breeding program subgroups (n subgroup1 = 352, n subgroup2 = 297) was found.