“highly significant”

Comparison with our dataset of ERG-regulated ASEs revealed that a highly significant proportion (132/410; 32.2%, P < 10E–50) of ERG-regulated ASEs were also sensitive to RBFOX2 knockdown (Figure 3D ).

For example, of 596 genes in cluster 6A ( Figure 6 ) ( R 2 =0.505), 165 were involved in the process of worm growth according the Gene Ontology annotations, representing a highly significant enrichment of gene function in this cluster ( P < 10 −49 ) (Supplementary Data).

Finally, the region of residence presented a highly significant association ( p < 10 −49 ), with a minimum expected value of 21,573, indicating a strong relationship between the place of residence and the distribution of maternal and late deaths, as shown in Table 3 .

Intriguingly, there was a highly significant region × chromosome interaction ( P = 2.35 × 10 −49 ) effect at the exon-level but not at the transcript-level ( P = 1.00).

This difference was highly significant ( P = 4.3E-49 in chi-square test; Supplementary Dataset S1).

The t- tests were found to be highly significant (p-value < 10 −48 ) when compared to the BNA causal nets based models, suggesting significant difference in the observed performances of the models raised during these tests when compared with the actual BNA based models.

These differences were highly significant across all immune parameters (Kruskal-Wallis P < 10 − 48 for all comparisons).

Consistent with our prior publications 14 , 15 , we found clear suppression of EWS::FLI1 induced targets that was highly significant at the TES with both LCE ( P = 1.1e-48) and HCE ( P = 1.5e-33)(Fig. 3b ).

Among CpG sites distinguishing current smokers versus never smokers in lung adenocarcinoma at P < 10 −4 (n = 296 sites), we observed highly significant enrichment for the adult blood signature at P = 1.2 × 10 −48 .

The model exhibited excellent discriminative power with a C-index of 0.901, and highly significant statistical results ( p = 1.207 × 10 −48 ).

This was a highly significant, greater than threefold enrichment (hypergeometric test p = 1.5 × 10 –48 ) of these families compared to their representation in the genome overall.

The UCP2–CD68 association remained highly significant after adjustment (partial ρ = 0.524, p = 1.80 × 10 − 48 ), confirming that the relationship between UCP2 expression and macrophage infiltration is not a spurious consequence of tumour purity variation ( Supplementary Fig.

The association between α 5 and phalloidin staining was highly significant ( P = 3.32 × 10 −48 ) ( Figure 1(c) , Table 1 ).

Comparison of the co-expression profile of CHRNA5 expression across 59 CCLE breast cancer cell lines with the logFC values from CHRNA5 RNAi profile revealed a highly significant negative correlation and association (r = -0.33, p = 3.8E-48).

Error t value Pr(>|t|) topME $ logFC -0.738 0.0472 -15.7 6.17e-48 > abline (RNAvsME, col = "red" , lwd = 2 ) The negative association is highly significant ( P = 6 × 10 − 48 ).

In addition, allele frequencies derived from the pooled sequencing experiment were compared to those derived from all individuals in the phase II genotype data and revealed a highly significant correlation (r = 0.971, p < 6.58x10 −48 ), further supporting the validity of the pooled sequencing approach.

When restricted to the 3,137 EUR cases with a PheCode probability >0.80 and their 12,548 matched controls, the 90-SNP weighted PRS was highly significant (odds ratio [OR] = 1.82 [95% confidence interval: 1.68–1.97]; p = 8.0 x 10 −48 ).

As it turned out, there is a highly significant association between induction in both systems (Fisher’s exact test p value = 1.3, 10–47).

A statistical comparison using Cochran's Q test revealed highly significant differences among the models (Q = 235.5, df = 7, p = 3.27E-47).

This 2.76-fold enrichment in this case is highly significant, with a Fisher exact test p = 8.20 × 10 −47 .

With a global average of 52.7% ± 0.12% history-congruent trials, we found a small but highly significant perceptual bias towards preceding experiences ( β = 16.18 ± 1.07, T(1.09×10 3 ) = 15.07, p = 10 −46 ; Fig 2A ) that was largely consistent across studies ( S1B Fig ) and more pronounced in participants who were less sensitive to external sensory information ( S1C Fig ).

When we test the association of each PC with ER status, PC1 scores have a highly significant association with ER status ( p < 10 −46 , Wilcoxon rank-sum test), whereas PC2 and PC3 are less associated (Fig. 2 b).

The libraries M19 and M25 have 0,985 as correlation coefficient and have a highly significant regression (P = 2,31 × 10 -46 , after Bonferroni correction P = 7,49 × 10 -43 ).

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.