“highly significant”

In postmenopausal women, there were highly significant reductions with the addition of bisphosphonates at 10 years for bone recurrence (6.6 vs 8.8%, p = 0.0002) and for breast cancer mortality (14.7 vs 18.0%, p = 0.002).

Similarly, the improvement in criterion two, from 61% to 85%, was highly significant (p=0.0002).

The final model had a highly significant (p = 0.0002) likelihood.

However, at higher HA wt% (50 and 75), there was a large, highly significant increase in compressive modulus (13.7 and 33.6 MPa, respectively, P < 0.0002 for both).

Methodological Quality Methodological quality as assessed by the Jadad score increased significantly over time (P<0.0001); we also reanalyzed the data minus the first period (1948–1953) (where the average Jadad score was much lower) and the increase over time was still highly significant (p = 0.0002) ( Figure 4 ).

When these outlier clusters were removed, intestinal habitats formed highly significant clusters according to diet (ANOSIM; P = 0.0002) (see Fig.

These curves clearly show that while thirds of IL-6 showed little discriminative ability in separating risk for nonfatal CVD in unadjusted models ( p = 0.13), associations with risk for fatal CVD events, fatal other CV events, or non-CVD mortality were all highly significant ( p ≤0.0002 for all).

Polygenic risk scores (PRS) for reproductive aging phenotypes and breast cancer risk The correlations between the PRS for each reproductive aging phenotype and the phenotype itself were highly significant as expected (p≤0.0002); yet the strength of the correlations was weak (correlation coefficient 0.16–0.21) ( Table 6 ).

There were pathogenic deletion variants in 5.26% of females and 3.69% of males, and this difference was highly significant (P < 0.0002) ( Fig. 2B ).

Analysis of IL-18 (mean [min/max]: 2,385 [300–8,025] pg/ml) and ECP (mean: 1,509 [<100/4,625] ng/ml) in 23 paired samples showed a highly significant correlation (r s = 0.70, P = 0.0002) between this cytokine and the eosinophil-derived product in the airways.

The difference between the cells infected with TTSuV1 and cells transfected with the unrelated DNA was highly significant at p = 0.0002 ( Fig. 2 ).

This decrease was highly significant compared with the control group ( p < 0.0002) and reflected a decrease in sulfate incorporation of 48% (Figure 1a ).

This proportion is highly significant (median test, P -value = 2 × 10 −4 ).

A highly significant negative correlation was seen between Mig-6 and FPG (r=−0.4991, p=0.0002), HbA1C (r=−0.4649, p=0.0008), and HOMA-IR (r=−0.4272, p=0.0027) ( figure 3 A).

However, when we pooled data for each continental group and compared the sub-Saharan component across all genomes within that group with the estimated Neanderthal ancestry in the same genomes, we found a highly significant negative correlation for Western Asia (rho=−0.234, P < 0.0002; supplementary table S2 , Supplementary Material online).

[ 5 ] reported median lesion size as highly significant (3 cm versus 2 cm; P = .0002) in a study of 40 patients with metastatic cSCC when compared to 153 cSCC patients without metastases.

Between 250–280 ms the DE was highly significant in both tasks (Numerical: p = 0.0002.

Smaller but highly significant increases in IL‐6 (32.2 pg/mL vs. 21.9 pg/mL, p = 0.0002), IL‐8 (55.6 pg/mL vs. 41.7 pg/mL, p = 0.007), and IP‐10 (1.2 ng/mL vs. 1.0 ng/mL, p = 0.04) were detected in cachectic patients.

Surprisingly, there was a highly significant excess of inter-chiral mating, both at each site separately, and using the pooled data ( χ 2 2 = 17.7; P = 0.0002; based on simulated random mating).

In addition, a weak yet highly significant positive correlation (rho = 0.49, p -value = 0.0002) was found between the overall metabolite load and the cell size during the growth phase ( Figure 5B ).

The interaction between intruder x resident genotype was also highly significant (F 2,40 = 10.71, p = 0.0002).

In an analysis of subgroups according to grade, no difference in terms of occurrence of metastatic disease was observed for grade 1 and 2 tumours between the treatment periods, whereas a highly significant increase in the number of patients with metastases for grade 3 tumours was noted in the recent period ( p = 0.0002).

Biological process annotations of these genes showed highly significant enrichment for lipid metabolism genes (P = 0.0002).

Overall, there was no significant effect of blister type on vaccination success based on dyed water marker (χ2 = 0.3145, df = 1, p = 0.5749), but there was a highly significant effect of bait type on vaccination success (effectiveness) (χ2 = 17.52, df = 2, p = 0.0002).

Secondary transplantations performed using tumour cells from two recipient animals demonstrated a highly significant reduction in disease latency (median 48 vs 132 days, p=0.0002) in keeping with evolution of the B220 + /Mac1 Int population to frankly malignant cells ( Figure 3e ).