“highly significant”

2C ), the reduction in non-NAb binding to the cross-linked trimers was highly significant compared to the bNAb group ( p = 0.0002, Mann-Whitney U test).

Substantial and highly significant levels of correlation between initial attainment rate and neutral zone were found for left (Rho = 0.75, P = 0.0002) and combined left-right bending (Rho = 0.72, P = 0.0001) and moderate ones for right alone (Rho = 0.55, P = 0.0012).

However, during reversal phase, the analysis of trials to criterion revealed a highly significant effect of WD in both 7 and 16 months old mice (Two-way ANOVA p = 0.0002, Bonferroni post tests * p < 0.05; Figure 1D ).

Using a permutation test, we found that the separation in monophyly score between core and accessory genes is highly significant (p = 0.0002).

For confirmation, we applied IFNA16 rs28368163 as a tag SNV in a second ET validation cohort (n = 54) and reconfirmed a highly significant association ( P = .0002) and OR (4.51; CI, 1.92-10.56), nearly identical to that found in Cohort 1 ( Table 2 ).

Moreover, a statistically significant ( P < 0.004) interaction between the organ sampling-time and the SNP treatment was revealed in kidney regardless of the dosing time, whereas a highly significant ( P < 0.0002) interaction was validated in liver only in animals injected at 13 HALO. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY 1.

This reduction was highly significant relative to that in CpG-A-treated cells from 10 healthy donors in 14 experiments ( p = 0.0002) and relative to control supernatants from Huh7.5 cells transfected with subgenomic replicon and rendered apoptotic by UV irradiation (p = 0.01).

In contrast, hypertensive patients exhibited markedly higher concentrations, averaging 3.0 ± 0.7 ng/mL, and this difference was highly significant ( p = 0.0002).

More precisely, a clear differentiation in the overlap type groups is evident, as both F-tests and P-tests [32] are highly significant (for F -test: p<0.0002; for P-test: p<0.001) which is further supported by the high bootstrap values obtained between the clades ( Figure 2 and Figures S1 and S2 ).

For instance, the genus Clostridium exhibited the highest mean relative abundance in the high Ca treatment (V), with highly significant differences ( p = 0.0002) compared to the control (K) and most other treatments.

The size of this effect was reflected in a highly significant group-level difference between Probe and Irrelevant (P3a-Fz: t (11) = 5.57, p <.0002; d = 1.61.

Secondary transplantations performed using tumour cells from two recipient animals demonstrated a highly significant reduction in disease latency (median 48 vs 132 days, p=0.0002) in keeping with evolution of the B220 + /Mac1 Int population to frankly malignant cells ( Figure 3e ).

Given the fraction of total axis length that was asynapsed in these syp-1 RNAi mnT12 nuclei, the observed restriction of GFP::COSA-1 foci to synapsed segments (where homologs are closely juxtaposed) represents a highly significant (χ 2 test; p = 0.0002) departure from the distribution expected if GFP::COSA-1 foci were equally likely to occur on synapsed segments and asynapsed segments (where homologs are separated), consistent with the interpretation that these GFP::COSA-1 foci correspond to interhomolog recombination events. 6 Extended Data Figure 4.

This difference is highly significant (p = 0.0002, chi-square test). 4.

The median plaque score difference on the 100 th day between the two groups was highly significant (p ≤0.0002).

A highly significant correlation existed between K i values and IC 50 values ( r = 0.82, P = 0.0002).

After adjusting for sex and health status, age-dependent changes remained highly significant in the N/NS pathway control ratio (slope = −0.0007, SD ± 0.0002, P = 0.0002) and the S/NS pathway control ratio for PBMCs (slope = 0.0010, SD ± 0.0002, P = < 0.0001) (Fig. 2 , Supplementary Table 5 ).

We find that there is a highly significant correlation between carrier status weighted by either acetylcholine EC 50 (β = −0.67, r 2 = 0.017, P = 2×10 −4 ) or by response to low nicotine (β = −0.29, r 2 = 0.02, P = 6×10 −5 ) when variants are expressed with the α3 subunit.

A highly significant positive correlation was observed across groups between the levels of Aβ-IgG immune complexes in CSF and serum ( r = 0.54, p = 0.0002; Figure S2 in the Supporting Information).

At all three protected lagoons there were highly significant temporal effects in the community composition (pseudo F = 3.14, P = 0.0002; F = 2.27, P = 0.009; F = 3.16, P = 0.0002 for Cemlyn, Pickleridge, and Morfa Gwyllt, respectively).

With the exception of the consumer price index, all the nominally significant variables displayed in Text S1 (Table A) remained highly significant (P<0.0002 or lower) after Bonferroni correction for multiple testing.

Apparent survival The U-CARE goodness of fit global test was highly significant (χ 2 = 36.93, d.f. = 12, p = 0.0002).

In the female subsample, the effects of DDSS and age were both highly significant (Q = 14.7; p = 0.0002, Q = 23.8; p < 0.0001, respectively), but the effect of DDSS on usability ratings was different for younger patients than it was for older participants (Q = 7.9; p = 0.005), suggesting that younger women (<52 years) showed greater usability rating differences between Ada and Rheport.

The analysis showed that the level of TMEM244 expression is negatively correlated with the square of the methylation level in the promoter region ( R = −0.4766), and this correlation is highly significant ( P < 0.0002) (Figure 4 ). 4 DISCUSSION In this study, we showed that methylation is a key regulatory mechanism of TMEM244 expression.

As demonstrated in Fig 4B , 12 out of 18 (66.7%) patient samples showed a highly significant increase in plasma CgA levels (P = 0.0002) during tumor progression which was in total nearly nine times higher (mean increase of 291.3 U/l) compared to samples derived from patients with NEN of the colon and rectum.