“highly significant”

Cox regression with clustering on pedigree showed that the exon was a highly significant predictor (χ 2 19.75 with 3 degrees of freedom, p = 0.0002).

This reduction was highly significant relative to that in CpG-A-treated cells from 10 healthy donors in 14 experiments ( p = 0.0002) and relative to control supernatants from Huh7.5 cells transfected with subgenomic replicon and rendered apoptotic by UV irradiation (p = 0.01).

The results as shown in Figure 5B , demonstrated a highly significant correlation for RIα up-regulated genes ((p < 2E-4) and RIIβ down-regulated genes (p < 1E-11) and the gene expression differences which distinguish myoblasts from myotube cells.

The family Sarcophagidae exhibited highly significant differences in relation to the altitude gradient (F = 7131, p = 0.0002, d.f. = 2).

The degree of the functional overlap across the six BR-signatures is highly significant (P = 0.0002) under a bootstrapped null distribution.

Noteworthy, RA-related phosphoprotein profile changes are unique to the CD19 + CD27 − IgD + IgM low/− subset of autoreactive B ND cells: nominal logistic fit demonstrated that RA predictive value of the combined phosphorylation profile of several major BCR signaling proteins and Ca 2+ levels in response to BCR stimulation [2] in B ND cells was highly significant (R 2 = 1.0, p = 0.0002), while in mature naïve CD19 + IgM + B cells this predictive value was substantially less evident (R 2 = 0.505, p = 0.053).

Apparent survival The U-CARE goodness of fit global test was highly significant (χ 2 = 36.93, d.f. = 12, p = 0.0002).

Analysis of IL-18 (mean [min/max]: 2,385 [300–8,025] pg/ml) and ECP (mean: 1,509 [<100/4,625] ng/ml) in 23 paired samples showed a highly significant correlation (r s = 0.70, P = 0.0002) between this cytokine and the eosinophil-derived product in the airways.

This was a highly significant difference ( p = 0.0002).

After regression analysis was performed, the quadratic polynomial regression equation describing the effects of CAR/GEL mass ratio (A), CS concentration (B), and GSA/CUR dosage (C) on the comprehensive score (Y) was obtained as follows: (11) Y = 0.66 − 0.041A + 0.019B + 0.036C + 0.061AB + 0.075AC + 0.027BC − 0.054A 2 − 0.091B 2 − 0.054C 2 Analysis of variance (ANOVA) for the response surface methodology (RSM) experiments ( Table 7 ) revealed the following: The regression model was highly significant ( p = 0.0002).

[ 5 ] reported median lesion size as highly significant (3 cm versus 2 cm; P = .0002) in a study of 40 patients with metastatic cSCC when compared to 153 cSCC patients without metastases.

Between 250–280 ms the DE was highly significant in both tasks (Numerical: p = 0.0002.

This decrease was highly significant compared with the control group ( p < 0.0002) and reflected a decrease in sulfate incorporation of 48% (Figure 1a ).

The interaction between intruder x resident genotype was also highly significant (F 2,40 = 10.71, p = 0.0002).

Analyzing the data by geographic region, we see that the results are highly significant for America–Asia–Australasia (χ 2 = 12.22, P = 0.0002; Fisher's P = 0.0003) and Africa–Asia–Australasia (χ 2 = 9.71, P = 0.0009; Fisher's P = 0.0021), and still significant although not as highly so if one only considers Asia–Australasia (χ 2 = 3.178, P = 0.0373; Fisher's P = 0.1558).

Overall, there was no significant effect of blister type on vaccination success based on dyed water marker (χ2 = 0.3145, df = 1, p = 0.5749), but there was a highly significant effect of bait type on vaccination success (effectiveness) (χ2 = 17.52, df = 2, p = 0.0002).

This proportion is highly significant (median test, P -value = 2 × 10 −4 ).

By day 3, the deficit was large and highly significant (sh-NC 2.21 ± 0.07 vs. sh-KCNN4 1.60 ± 0.13; mean difference 0.60 [95% CI 0.40–0.81]; adjusted P = 0.0002).These findings demonstrate a time-dependent and quantitatively large suppression of PC-9 proliferation following KCNN4 knockdown.

Highly significant association was seen between breast cancer and carrying either of the mutations (OR 1.86, 95% CI 1.32–2.49, P = 0.0002).

vivax infections (23–79%) was highly significant ( P = 0.0002), as was the variation in mean MOI (1.23–1.90); P = 0.0002.

At the same time, 4 patients encountered graft-rejection, and 7 patients died of HSCT-related complications, indicating a highly significant impact of HSCT on the survival rate of patients with actinopathies ( p = 0.0002, Figure 3 ).

Interestingly, our data revealed that a highly significant increase in myocilin expression (11.8-fold) was observed in TM region of the responder eyes compared to vehicle-treated eyes ( p = 0.0002); and there was a fourfold increase in myocilin expression in GC responder eyes ( p = 0.0004) compared with GC non-responder eyes.

A highly significant negative correlation was seen between Mig-6 and FPG (r=−0.4991, p=0.0002), HbA1C (r=−0.4649, p=0.0008), and HOMA-IR (r=−0.4272, p=0.0027) ( figure 3 A).

Notably, the lowest tested concentration of HYAL (0.015 U/ml) demonstrated a highly significant induction of HAS2 expression compared to medium control (Fig. 2 b, p = 0.0002).

This difference was highly significant (GROUP effect: F = 21.18; P = 0.0002; Fig. 3a ) and was apparent during both the ramp and hold phases, and at both force levels (P = 0.01).