“highly significant”

Although observing two siRNA sharing a hexamer seed sequence is not significant at the 5% level, observing two or more such seeds is significant (P = 0.013), while finding four siRNAs sharing a seed sequence is highly significant (P < 0.0002).

A highly significant correlation was obtained for tumor volume measurements (Pearson correlation coefficient r = 0.90, CI: 0.654 – 0.974, p = 0.0002) using micro-CT-scan examination when compared to autopsy findings (Fig. 4b ).

55 At 12 months after MSC administration, patients exhibited a highly significant improvement in the primary endpoint (change in LVESV) relative to placebo (−17 mL; P < 0.0002), which was associated with a highly significant improvement in LVEF (+6.2 units; P < 0.0001), myocardial mass (+9.8 g; P = 0.09), and quality of life ( Figure 1 ).

9 , bottom row); these differences were significant for all groups including the LVS Δ capB vector in experiment 1 (ranging between P < 0.05 to P < 0.01) and for all but the parental vector and one vaccine in experiment 2 (ranging from P < 0.05 to P < 0.0001); combining all LVS Δ capB and r LVS Δ capB /Bp vaccines, the increase in antibody to HI Bp82 was highly significant ( P = 0.0002 and P < 0.0001 by two-tailed t test in experiments 1 and 2, respectively).

Similarly, the relationship between support for recycling and the belief in the economic benefit of recycling shows an intercept of 3.782 and a highly significant coefficient of 0.2084 ( P = 0.0002), with a confidence interval from 0.098 to 0.318.

1 B, there was a highly significant correlation (R = 0.74, p = 0.0002) between body weight and liver PAR2 expression in PAR2 ΔHep mice vs. wild-type (WT; PAR2 fl/fl ).

Methodological Quality Methodological quality as assessed by the Jadad score increased significantly over time (P<0.0001); we also reanalyzed the data minus the first period (1948–1953) (where the average Jadad score was much lower) and the increase over time was still highly significant (p = 0.0002) ( Figure 4 ).

The difference between chronological and predicted ages in AD was highly significant ( p = 0.0002), whereas the difference in chronological and predicted ages in normal controls was not ( p = 0.97) ( Figure 3 ).

There was highly significant association between the number of drugs prescribed and frequency of use of PIMs ( P < 0. 0002).

This analysis showed a highly significant difference ( p = 0.0002), highlighting that fistulectomy improves the quality of postoperative evacuations by promoting more formed and regular stools than fistulotomy.

This would be highly significant statistically ( p = 0.0002), but Steinmann’s description was limited to a schema, without narrative details, and Schwingenheuer’s was also brief.

We observed a highly significant and highly variable F IS ( F IS = 0.285, p -value > 0.0002, 95% CI = [-0.021, 0.261]) ( Fig 3 ).

The chi-square test for heterogeneity was highly significant ( P = 0.0002), indicating substantial difference between the individual trials results.

We found a modest but highly significant increase in Sgg::YFP levels at stimulated NMJs (12.4 ± 0.02%; P = 0.0002, Student’s t test; Fig. 8, I–K ).

After regression analysis was performed, the quadratic polynomial regression equation describing the effects of CAR/GEL mass ratio (A), CS concentration (B), and GSA/CUR dosage (C) on the comprehensive score (Y) was obtained as follows: (11) Y = 0.66 − 0.041A + 0.019B + 0.036C + 0.061AB + 0.075AC + 0.027BC − 0.054A 2 − 0.091B 2 − 0.054C 2 Analysis of variance (ANOVA) for the response surface methodology (RSM) experiments ( Table 7 ) revealed the following: The regression model was highly significant ( p = 0.0002).

There was highly significant difference on RI value at day 14 in dogs graded on day 1 of the trial as nonambulatory paraparetic versus paraplegic ( P = .0002), but treatment group remained not significant because of equal distribution of these grades between groups ( P = .73). 3.2.

Water Relations For the reductions seen for midday leaf water potential (ψ) in ungrafted and grafted plants, salinity (i.e., salt stress) and date of measurements proved to be highly significant factors ( p = 0.0002, p < 0.0001, respectively).

For example, the spread of saccade latencies was 3.2 times smaller than that of hand latencies, a highly significant difference ( p < 0.0002; Bartlett's test), in neuron R238 which occupies one end of this range.

These curves clearly show that while thirds of IL-6 showed little discriminative ability in separating risk for nonfatal CVD in unadjusted models ( p = 0.13), associations with risk for fatal CVD events, fatal other CV events, or non-CVD mortality were all highly significant ( p ≤0.0002 for all).

Quantitative analysis of RT-qPCR data revealed that, in breast cancer (BC) samples relative to control samples, PGR exhibited a 0.649-fold expression change with a non-significant difference (p = 0.0599); CD14 showed a 0.459-fold reduction with a highly significant difference (p = 0.0002); PPARG displayed a 0.480-fold downregulation with a significant difference (p = 0.0012); CHRM1 presented a 0.515-fold decrease with a significant difference (p = 0.0034); and HTR3A had a negligible 1.026-fold expression alteration with no statistical significance (p = 0.1223).

Comparing the mRNA levels of tissue samples obtained from the dorsal horn of control animals and from the dorsal horn of CFA-injected animals ipsilateral to the CFA injection at post-injection day 3 (at the peak of mechanical allodynia), we observed a highly significant, approximately six times increase in the IL-1R1 mRNA ( p = 0.0002) in the experimental animals (Table 2 ).

The results as shown in Figure 5B , demonstrated a highly significant correlation for RIα up-regulated genes ((p < 2E-4) and RIIβ down-regulated genes (p < 1E-11) and the gene expression differences which distinguish myoblasts from myotube cells.

At the same time, 4 patients encountered graft-rejection, and 7 patients died of HSCT-related complications, indicating a highly significant impact of HSCT on the survival rate of patients with actinopathies ( p = 0.0002, Figure 3 ).

The analysis showed that the level of TMEM244 expression is negatively correlated with the square of the methylation level in the promoter region ( R = −0.4766), and this correlation is highly significant ( P < 0.0002) (Figure 4 ). 4 DISCUSSION In this study, we showed that methylation is a key regulatory mechanism of TMEM244 expression.

Interestingly, the difference in means of the HER2/CEP17 ratio was highly significant for MP high-risk versus low-risk tumors ( P = .0002; 95% CI for true difference in log-transformed means, 0.40 to 1.06).